Study of dynamic brain function in irritable bowel syndrome via Hidden Markov Modeling
Background and purposeIrritable bowel syndrome (IBS) is a common bowel-brain interaction disorder whose pathogenesis is unclear. Many studies have investigated abnormal changes in brain function in IBS patients. In this study, we analyzed the dynamic changes in brain function in IBS patients using a...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1515540/full |
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| author | Chuan Jing Tianci Liu Qingzhou Li Chuan Zhang Baijintao Sun Xuezhao Yang Yutao You Jixin Liu Hanfeng Yang |
| author_facet | Chuan Jing Tianci Liu Qingzhou Li Chuan Zhang Baijintao Sun Xuezhao Yang Yutao You Jixin Liu Hanfeng Yang |
| author_sort | Chuan Jing |
| collection | DOAJ |
| description | Background and purposeIrritable bowel syndrome (IBS) is a common bowel-brain interaction disorder whose pathogenesis is unclear. Many studies have investigated abnormal changes in brain function in IBS patients. In this study, we analyzed the dynamic changes in brain function in IBS patients using a Hidden Markov Model (HMM).MethodsResting-state functional magnetic resonance imaging (rs-fMRI) data and the clinical characteristics of 35 patients with IBS and 31 healthy controls (HCs) were collected. The rs-fMRI data of all participants were analyzed using HMM to identify recurrent brain activity states that evolve over time during the resting state. Additionally, the temporal properties of these HMM states and their correlations with clinical scale scores were examined.ResultThis study utilized the Hidden Markov Model (HMM) method to identify six distinct HMM states. Significant differences in fractional occupancy (FO) and lifetime (LT) were observed in states 5 and 6 between the IBS and HCs. The state transition probabilities differed between IBS and HCs, with an increased probability of transitioning from state 2 to state 6 in IBS patients. The reconfiguration of HMM states over time scales in IBS patients was associated with abnormal activity in the default mode network (DMN), sensorimotor network (SMN), and cingulo-opercular network (CON).ConclusionThis study offers novel insights into the dynamic reorganization of brain activity patterns in IBS and elucidates potential links between these patterns and IBS-related emotional regulation and symptom experience, thereby contributing to a deeper understanding of the neural mechanisms underlying IBS. |
| format | Article |
| id | doaj-art-9548206e0a9b4221a68c72b51bdb8502 |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj-art-9548206e0a9b4221a68c72b51bdb85022025-01-13T06:10:32ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-01-011810.3389/fnins.2024.15155401515540Study of dynamic brain function in irritable bowel syndrome via Hidden Markov ModelingChuan Jing0Tianci Liu1Qingzhou Li2Chuan Zhang3Baijintao Sun4Xuezhao Yang5Yutao You6Jixin Liu7Hanfeng Yang8Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaCenter for Brain Imaging, School of Life Science and Technology, Xidian University, Xi’an, ChinaDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaBackground and purposeIrritable bowel syndrome (IBS) is a common bowel-brain interaction disorder whose pathogenesis is unclear. Many studies have investigated abnormal changes in brain function in IBS patients. In this study, we analyzed the dynamic changes in brain function in IBS patients using a Hidden Markov Model (HMM).MethodsResting-state functional magnetic resonance imaging (rs-fMRI) data and the clinical characteristics of 35 patients with IBS and 31 healthy controls (HCs) were collected. The rs-fMRI data of all participants were analyzed using HMM to identify recurrent brain activity states that evolve over time during the resting state. Additionally, the temporal properties of these HMM states and their correlations with clinical scale scores were examined.ResultThis study utilized the Hidden Markov Model (HMM) method to identify six distinct HMM states. Significant differences in fractional occupancy (FO) and lifetime (LT) were observed in states 5 and 6 between the IBS and HCs. The state transition probabilities differed between IBS and HCs, with an increased probability of transitioning from state 2 to state 6 in IBS patients. The reconfiguration of HMM states over time scales in IBS patients was associated with abnormal activity in the default mode network (DMN), sensorimotor network (SMN), and cingulo-opercular network (CON).ConclusionThis study offers novel insights into the dynamic reorganization of brain activity patterns in IBS and elucidates potential links between these patterns and IBS-related emotional regulation and symptom experience, thereby contributing to a deeper understanding of the neural mechanisms underlying IBS.https://www.frontiersin.org/articles/10.3389/fnins.2024.1515540/fullirritable bowel syndromeHidden Markov Modelresting-state functional magnetic resonance imagingdynamic brain functioningbrain state |
| spellingShingle | Chuan Jing Tianci Liu Qingzhou Li Chuan Zhang Baijintao Sun Xuezhao Yang Yutao You Jixin Liu Hanfeng Yang Study of dynamic brain function in irritable bowel syndrome via Hidden Markov Modeling Frontiers in Neuroscience irritable bowel syndrome Hidden Markov Model resting-state functional magnetic resonance imaging dynamic brain functioning brain state |
| title | Study of dynamic brain function in irritable bowel syndrome via Hidden Markov Modeling |
| title_full | Study of dynamic brain function in irritable bowel syndrome via Hidden Markov Modeling |
| title_fullStr | Study of dynamic brain function in irritable bowel syndrome via Hidden Markov Modeling |
| title_full_unstemmed | Study of dynamic brain function in irritable bowel syndrome via Hidden Markov Modeling |
| title_short | Study of dynamic brain function in irritable bowel syndrome via Hidden Markov Modeling |
| title_sort | study of dynamic brain function in irritable bowel syndrome via hidden markov modeling |
| topic | irritable bowel syndrome Hidden Markov Model resting-state functional magnetic resonance imaging dynamic brain functioning brain state |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1515540/full |
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