Cross-species analysis of genetic architecture and polygenic risk scores for non-contact ACL rupture in dogs and humans

Cross-species analysis of genetic architecture and polygenic risk scores for non-contact ACL rupture in dogs and humans

Abstract Non-contact anterior cruciate ligament (ACL) rupture is a common serious orthopaedic disease in humans and dogs. Familial risk has been recognized in both species but interactions between genetic effects and environmental risk are not understood. We investigated ACL rupture heritability, ge...

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Bibliographic Details
Main Authors: Mehdi Momen, Hannah K. Kearney, Margaret M. Patterson, Susannah J. Sample, Zijie Zhao, Qiongshi Lu, Guilherme J. M. Rosa, Peter Muir
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07395-9
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