Thermal behavior and biological activity of [Co2(Cl)2 tpmc](BF4)2 complex
A large number of interesting Co (II) complexes with macrocyclicligands have been synthesized and the recognition of its complexes as important bioactive compounds in vitro and in vivo has aroused growing interest in these agents as potential drugs for therapeutic use in various diseases. Numerous a...
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Engineering Society for Corrosion, Belgrade, Serbia
2021-12-01
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| Series: | Zaštita Materijala |
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| Online Access: | https://www.zastita-materijala.org/index.php/home/article/view/199 |
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| author | Branka Dražić Nikolić Mirjana Antonijević |
| author_facet | Branka Dražić Nikolić Mirjana Antonijević |
| author_sort | Branka Dražić |
| collection | DOAJ |
| description | A large number of interesting Co (II) complexes with macrocyclicligands have been synthesized and the recognition of its complexes as important bioactive compounds in vitro and in vivo has aroused growing interest in these agents as potential drugs for therapeutic use in various diseases. Numerous available information on their bioinorganic properties and mode of action in several biological systems, combined with the new possibilities imposed by the development of medical chemistry, opens space for the development of a new generation of highly active drugs with minimized side effects which could add significantly to the current clinical research and practice. In this paper we attempt to present some properties of the earlier isolated the first Co(II)tpmc complex for which crystal structure confirmed chair conformation of macrocycle. Complex with formula (Co2(Cl)2tpmc)(BF4)2 (tpmc = N,N',N'',N'''tetrakis(2-pyridylmethyl)-1,4,8,11 - tetraazacyclotetradecane), was studied on thermal behaviour and biological activity. TG-DTA analysis indicates that complex decomposition in a single step in the range of 365 -435 °C. Investigated cytotoxic activity against two human cancer cell lines: HeLa (human cervix adenocarcinoma) and K562 (human myelogenous leukaemia). Complex was also preliminary assayed in vitro toward bacteria, fungi and mould together with the starting material for the synthesis (ligands, simple salts and solvents) as test substances. Investigated complex showed a moderate activity against strains of bacteria and were inactive against the tested fungi and mould. Minimal inhibitory concentration suppressing the visible growth of bacteria was determined. Biological investigations show the complex has significant cytotoxic potential. |
| format | Article |
| id | doaj-art-94e90b4d0f784447be4ca54f61f0caa9 |
| institution | Kabale University |
| issn | 0351-9465 2466-2585 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Engineering Society for Corrosion, Belgrade, Serbia |
| record_format | Article |
| series | Zaštita Materijala |
| spelling | doaj-art-94e90b4d0f784447be4ca54f61f0caa92024-12-09T17:01:09ZengEngineering Society for Corrosion, Belgrade, SerbiaZaštita Materijala0351-94652466-25852021-12-0162429129610.5937/zasmat2104291T198Thermal behavior and biological activity of [Co2(Cl)2 tpmc](BF4)2 complexBranka Dražić0Nikolić Mirjana Antonijević1University of Belgrade, Faculty of Pharmacy, SerbiaAcademy of applied studies, Department for medical, business and technological studies, ŠabacA large number of interesting Co (II) complexes with macrocyclicligands have been synthesized and the recognition of its complexes as important bioactive compounds in vitro and in vivo has aroused growing interest in these agents as potential drugs for therapeutic use in various diseases. Numerous available information on their bioinorganic properties and mode of action in several biological systems, combined with the new possibilities imposed by the development of medical chemistry, opens space for the development of a new generation of highly active drugs with minimized side effects which could add significantly to the current clinical research and practice. In this paper we attempt to present some properties of the earlier isolated the first Co(II)tpmc complex for which crystal structure confirmed chair conformation of macrocycle. Complex with formula (Co2(Cl)2tpmc)(BF4)2 (tpmc = N,N',N'',N'''tetrakis(2-pyridylmethyl)-1,4,8,11 - tetraazacyclotetradecane), was studied on thermal behaviour and biological activity. TG-DTA analysis indicates that complex decomposition in a single step in the range of 365 -435 °C. Investigated cytotoxic activity against two human cancer cell lines: HeLa (human cervix adenocarcinoma) and K562 (human myelogenous leukaemia). Complex was also preliminary assayed in vitro toward bacteria, fungi and mould together with the starting material for the synthesis (ligands, simple salts and solvents) as test substances. Investigated complex showed a moderate activity against strains of bacteria and were inactive against the tested fungi and mould. Minimal inhibitory concentration suppressing the visible growth of bacteria was determined. Biological investigations show the complex has significant cytotoxic potential.https://www.zastita-materijala.org/index.php/home/article/view/199co(ii) complextpmcmicrobiological activitycytotoxic activitythermal behavior |
| spellingShingle | Branka Dražić Nikolić Mirjana Antonijević Thermal behavior and biological activity of [Co2(Cl)2 tpmc](BF4)2 complex Zaštita Materijala co(ii) complex tpmc microbiological activity cytotoxic activity thermal behavior |
| title | Thermal behavior and biological activity of [Co2(Cl)2 tpmc](BF4)2 complex |
| title_full | Thermal behavior and biological activity of [Co2(Cl)2 tpmc](BF4)2 complex |
| title_fullStr | Thermal behavior and biological activity of [Co2(Cl)2 tpmc](BF4)2 complex |
| title_full_unstemmed | Thermal behavior and biological activity of [Co2(Cl)2 tpmc](BF4)2 complex |
| title_short | Thermal behavior and biological activity of [Co2(Cl)2 tpmc](BF4)2 complex |
| title_sort | thermal behavior and biological activity of co2 cl 2 tpmc bf4 2 complex |
| topic | co(ii) complex tpmc microbiological activity cytotoxic activity thermal behavior |
| url | https://www.zastita-materijala.org/index.php/home/article/view/199 |
| work_keys_str_mv | AT brankadrazic thermalbehaviorandbiologicalactivityofco2cl2tpmcbf42complex AT nikolicmirjanaantonijevic thermalbehaviorandbiologicalactivityofco2cl2tpmcbf42complex |