Fractional exhaled nitric oxide in a respiratory healthy general population through the lifespan
Introduction and Objectives The fractional exhaled fraction of nitric oxide (FeNO) is used in clinical practice for asthma diagnosis, phenotyping, and therapeutic management. Therefore, accurate thresholds are crucial. The normal FeNO values over lifespan in a respiratory healthy population and the...
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| Language: | English |
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Taylor & Francis
2025-12-01
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| Series: | Pulmonology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/25310429.2024.2442662 |
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| author | Christina Bal Caspar Schiffers Marie-Kathrin Breyer Sylvia Hartl Alvar Agusti Ahmad Karimi Wolfgang Pohl Marco Idzko Robab Breyer-Kohansal |
| author_facet | Christina Bal Caspar Schiffers Marie-Kathrin Breyer Sylvia Hartl Alvar Agusti Ahmad Karimi Wolfgang Pohl Marco Idzko Robab Breyer-Kohansal |
| author_sort | Christina Bal |
| collection | DOAJ |
| description | Introduction and Objectives The fractional exhaled fraction of nitric oxide (FeNO) is used in clinical practice for asthma diagnosis, phenotyping, and therapeutic management. Therefore, accurate thresholds are crucial. The normal FeNO values over lifespan in a respiratory healthy population and the factors related to them remain unclear.Materials and Methods We determined FeNO levels in 2,251 respiratory healthy, non-atopic, and non-smoking participants from the Lung, hEart, sociAl, boDy (LEAD) cohort, a general population, observational cohort study of participants aged 6–82 years in Austria.Results The median FeNO value in the total study population was 13.0 [interquartile range: 9.0, 20.0] ppb, increases with age, and, except in young participants (<18 years: 9.0 [7.0, 12.0], ≥18 years: 15.0 [11.0, 22.0]), it was significantly lower in females versus males. Multiple regression analyses showed that body height and blood eosinophil counts were associated with higher FeNO levels, both in children/adolescents and adults. In children/adolescents, FeNO values were positively associated with total IgE levels, FEV1/FVC ratio, and urban living. In adults, FeNO was positively associated with age and negatively associated with the presence of cardiovascular and ischaemic vascular disease.Conclusions We identified the normal FeNO ranges within a respiratory healthy population at different age ranges and associated factors. Collectively, they serve as a reference to frame FeNO values in clinical practice. |
| format | Article |
| id | doaj-art-94d0d875758c474d9d8b985b083989a3 |
| institution | Kabale University |
| issn | 2531-0429 2531-0437 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis |
| record_format | Article |
| series | Pulmonology |
| spelling | doaj-art-94d0d875758c474d9d8b985b083989a32025-01-06T14:32:14ZengTaylor & FrancisPulmonology2531-04292531-04372025-12-0131110.1080/25310429.2024.2442662Fractional exhaled nitric oxide in a respiratory healthy general population through the lifespanChristina Bal0Caspar Schiffers1Marie-Kathrin Breyer2Sylvia Hartl3Alvar Agusti4Ahmad Karimi5Wolfgang Pohl6Marco Idzko7Robab Breyer-Kohansal8Department of Pneumology, University Hospital Vienna AKH, Medical University of Vienna, Vienna, AustriaLudwig Boltzmann Institute for Lung Health, Vienna, AustriaLudwig Boltzmann Institute for Lung Health, Vienna, AustriaLudwig Boltzmann Institute for Lung Health, Vienna, AustriaLudwig Boltzmann Institute for Lung Health, Vienna, AustriaLudwig Boltzmann Institute for Lung Health, Vienna, AustriaDepartment of Respiratory and Lung Diseases, Karl Landsteiner Institute for Experimental and Clinical PneumologyDepartment of Pneumology, University Hospital Vienna AKH, Medical University of Vienna, Vienna, AustriaLudwig Boltzmann Institute for Lung Health, Vienna, AustriaIntroduction and Objectives The fractional exhaled fraction of nitric oxide (FeNO) is used in clinical practice for asthma diagnosis, phenotyping, and therapeutic management. Therefore, accurate thresholds are crucial. The normal FeNO values over lifespan in a respiratory healthy population and the factors related to them remain unclear.Materials and Methods We determined FeNO levels in 2,251 respiratory healthy, non-atopic, and non-smoking participants from the Lung, hEart, sociAl, boDy (LEAD) cohort, a general population, observational cohort study of participants aged 6–82 years in Austria.Results The median FeNO value in the total study population was 13.0 [interquartile range: 9.0, 20.0] ppb, increases with age, and, except in young participants (<18 years: 9.0 [7.0, 12.0], ≥18 years: 15.0 [11.0, 22.0]), it was significantly lower in females versus males. Multiple regression analyses showed that body height and blood eosinophil counts were associated with higher FeNO levels, both in children/adolescents and adults. In children/adolescents, FeNO values were positively associated with total IgE levels, FEV1/FVC ratio, and urban living. In adults, FeNO was positively associated with age and negatively associated with the presence of cardiovascular and ischaemic vascular disease.Conclusions We identified the normal FeNO ranges within a respiratory healthy population at different age ranges and associated factors. Collectively, they serve as a reference to frame FeNO values in clinical practice.https://www.tandfonline.com/doi/10.1080/25310429.2024.2442662Airway inflammationassociated factorsasthmafraction of exhaled nitric oxide (FeNO)reference values |
| spellingShingle | Christina Bal Caspar Schiffers Marie-Kathrin Breyer Sylvia Hartl Alvar Agusti Ahmad Karimi Wolfgang Pohl Marco Idzko Robab Breyer-Kohansal Fractional exhaled nitric oxide in a respiratory healthy general population through the lifespan Pulmonology Airway inflammation associated factors asthma fraction of exhaled nitric oxide (FeNO) reference values |
| title | Fractional exhaled nitric oxide in a respiratory healthy general population through the lifespan |
| title_full | Fractional exhaled nitric oxide in a respiratory healthy general population through the lifespan |
| title_fullStr | Fractional exhaled nitric oxide in a respiratory healthy general population through the lifespan |
| title_full_unstemmed | Fractional exhaled nitric oxide in a respiratory healthy general population through the lifespan |
| title_short | Fractional exhaled nitric oxide in a respiratory healthy general population through the lifespan |
| title_sort | fractional exhaled nitric oxide in a respiratory healthy general population through the lifespan |
| topic | Airway inflammation associated factors asthma fraction of exhaled nitric oxide (FeNO) reference values |
| url | https://www.tandfonline.com/doi/10.1080/25310429.2024.2442662 |
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