Ferroptosis as an emerging target in sickle cell disease

Ferroptosis as an emerging target in sickle cell disease

Sickle cell disease (SCD) is an inherited hemoglobin disorder marked by red blood cell sickling, resulting in severe anemia, painful episodes, extensive organ damage, and shortened life expectancy. In SCD, increased iron levels can trigger ferroptosis, a specific type of cell death characterized by...

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Bibliographic Details
Main Authors: Vitor Fortuna, Jaqueline Lima, Gabriel F. Oliveira, Yasmin S. Oliveira, Bruk Getachew, Sergei Nekhai, Michael Aschner, Yousef Tizabi
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Current Research in Toxicology
Subjects:
Sickle cell disease
Iron toxicity
Ferroptosis
Oxidative stress
Lipid peroxidation
Novel targets
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X24000343
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Summary:Sickle cell disease (SCD) is an inherited hemoglobin disorder marked by red blood cell sickling, resulting in severe anemia, painful episodes, extensive organ damage, and shortened life expectancy. In SCD, increased iron levels can trigger ferroptosis, a specific type of cell death characterized by reactive oxygen species (ROS) and lipid peroxide accumulation, leading to damage and organ impairments. The intricate interplay between iron, ferroptosis, inflammation, and oxidative stress in SCD underscores the necessity of thoroughly understanding these processes for the development of innovative therapeutic strategies. This review highlights the importance of balancing the complex interactions among various factors and exploitation of the knowledge in developing novel therapeutics for this devastating disease.
ISSN:2666-027X

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