Natural Antimicrobial Peptides and Their Synthetic Analogues for Effective Oral Microflora Control and Oral Infection Treatment—The Role of Ceragenins in the Development of New Therapeutic Methods
Oral diseases, both acute and chronic, of infectious or non-infectious etiology, represent some of the most serious medical problems in dentistry. Data from the literature increasingly indicate that changes in the oral microbiome, and therefore, the overgrowing of pathological microflora, lead to a...
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2024-12-01
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| author | Michał Czarnowski Urszula Wnorowska Milena Łuckiewicz Ewelina Dargiewicz Jakub Spałek Sławomir Okła Beata Sawczuk Paul B. Savage Robert Bucki Ewelina Piktel |
| author_facet | Michał Czarnowski Urszula Wnorowska Milena Łuckiewicz Ewelina Dargiewicz Jakub Spałek Sławomir Okła Beata Sawczuk Paul B. Savage Robert Bucki Ewelina Piktel |
| author_sort | Michał Czarnowski |
| collection | DOAJ |
| description | Oral diseases, both acute and chronic, of infectious or non-infectious etiology, represent some of the most serious medical problems in dentistry. Data from the literature increasingly indicate that changes in the oral microbiome, and therefore, the overgrowing of pathological microflora, lead to a variety of oral-localized medical conditions such as caries, gingivitis, and periodontitis. In recent years, compelling research has been devoted to the use of natural antimicrobial peptides as therapeutic agents in the possible treatment of oral diseases. This review focuses on the potential of ceragenins (CSAs), which are lipid analogs of natural antimicrobial peptides, as molecules for the development of new methods for the prevention and treatment of oral diseases. Studies to date indicate that ceragenins, with their spectrum of multidirectional biological activities, including antimicrobial, tissue regeneration-stimulating, anti-inflammatory, and immunomodulatory properties, are strong candidates for further development of oral formulations. However, many of the beneficial properties of ceragenins require confirmation in experimental conditions reproducing the oral environment to fully determine their application potential. Their transition to practical use also requires more advanced testing of these molecules in clinical trials, which have only been conducted in limited numbers to date. |
| format | Article |
| id | doaj-art-9495c52791f64da5ac2627c7ea12f50c |
| institution | Kabale University |
| issn | 1424-8247 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-9495c52791f64da5ac2627c7ea12f50c2024-12-27T14:46:12ZengMDPI AGPharmaceuticals1424-82472024-12-011712172510.3390/ph17121725Natural Antimicrobial Peptides and Their Synthetic Analogues for Effective Oral Microflora Control and Oral Infection Treatment—The Role of Ceragenins in the Development of New Therapeutic MethodsMichał Czarnowski0Urszula Wnorowska1Milena Łuckiewicz2Ewelina Dargiewicz3Jakub Spałek4Sławomir Okła5Beata Sawczuk6Paul B. Savage7Robert Bucki8Ewelina Piktel9Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, 15-222 Bialystok, PolandDepartment of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, 15-222 Bialystok, PolandIndependent Laboratory of Nanomedicine, Medical University of Bialystok, 15-222 Bialystok, PolandDepartment of Orthodontics, Medical University of Bialystok, 15-269 Bialystok, PolandInstitute of Medical Sciences, Collegium Medicum, Jan Kochanowski University of Kielce, 25-369 Kielce, PolandInstitute of Medical Sciences, Collegium Medicum, Jan Kochanowski University of Kielce, 25-369 Kielce, PolandDepartment of Prosthodontics, Medical University of Bialystok, 15-276 Bialystok, PolandDepartment of Chemistry & Biochemistry, Brigham Young University, Provo, UT 84602, USADepartment of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, 15-222 Bialystok, PolandIndependent Laboratory of Nanomedicine, Medical University of Bialystok, 15-222 Bialystok, PolandOral diseases, both acute and chronic, of infectious or non-infectious etiology, represent some of the most serious medical problems in dentistry. Data from the literature increasingly indicate that changes in the oral microbiome, and therefore, the overgrowing of pathological microflora, lead to a variety of oral-localized medical conditions such as caries, gingivitis, and periodontitis. In recent years, compelling research has been devoted to the use of natural antimicrobial peptides as therapeutic agents in the possible treatment of oral diseases. This review focuses on the potential of ceragenins (CSAs), which are lipid analogs of natural antimicrobial peptides, as molecules for the development of new methods for the prevention and treatment of oral diseases. Studies to date indicate that ceragenins, with their spectrum of multidirectional biological activities, including antimicrobial, tissue regeneration-stimulating, anti-inflammatory, and immunomodulatory properties, are strong candidates for further development of oral formulations. However, many of the beneficial properties of ceragenins require confirmation in experimental conditions reproducing the oral environment to fully determine their application potential. Their transition to practical use also requires more advanced testing of these molecules in clinical trials, which have only been conducted in limited numbers to date.https://www.mdpi.com/1424-8247/17/12/1725antimicrobial peptidesoral cavityceragenins |
| spellingShingle | Michał Czarnowski Urszula Wnorowska Milena Łuckiewicz Ewelina Dargiewicz Jakub Spałek Sławomir Okła Beata Sawczuk Paul B. Savage Robert Bucki Ewelina Piktel Natural Antimicrobial Peptides and Their Synthetic Analogues for Effective Oral Microflora Control and Oral Infection Treatment—The Role of Ceragenins in the Development of New Therapeutic Methods Pharmaceuticals antimicrobial peptides oral cavity ceragenins |
| title | Natural Antimicrobial Peptides and Their Synthetic Analogues for Effective Oral Microflora Control and Oral Infection Treatment—The Role of Ceragenins in the Development of New Therapeutic Methods |
| title_full | Natural Antimicrobial Peptides and Their Synthetic Analogues for Effective Oral Microflora Control and Oral Infection Treatment—The Role of Ceragenins in the Development of New Therapeutic Methods |
| title_fullStr | Natural Antimicrobial Peptides and Their Synthetic Analogues for Effective Oral Microflora Control and Oral Infection Treatment—The Role of Ceragenins in the Development of New Therapeutic Methods |
| title_full_unstemmed | Natural Antimicrobial Peptides and Their Synthetic Analogues for Effective Oral Microflora Control and Oral Infection Treatment—The Role of Ceragenins in the Development of New Therapeutic Methods |
| title_short | Natural Antimicrobial Peptides and Their Synthetic Analogues for Effective Oral Microflora Control and Oral Infection Treatment—The Role of Ceragenins in the Development of New Therapeutic Methods |
| title_sort | natural antimicrobial peptides and their synthetic analogues for effective oral microflora control and oral infection treatment the role of ceragenins in the development of new therapeutic methods |
| topic | antimicrobial peptides oral cavity ceragenins |
| url | https://www.mdpi.com/1424-8247/17/12/1725 |
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