Extraction, purification, structural characterization, bioactivities, modifications and structure–activity relationship of polysaccharides from Ophiopogon japonicus: a review
Ophiopogon japonicus (Thunb.) Ker Gawl., is a traditional Chinese medicine (TCM) with a history of thousands of years. O. japonicus polysaccharides (OJPs), as one of the main active ingredient, are a kind of representative pharmacological bioactive macromolecules and mainly composed of Glc and Fru w...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1484865/full |
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| author | Yiqiang Zhang Bo Chen Bo Chen Hua Zhang Juan Zhang Juan Xue Juan Xue |
| author_facet | Yiqiang Zhang Bo Chen Bo Chen Hua Zhang Juan Zhang Juan Xue Juan Xue |
| author_sort | Yiqiang Zhang |
| collection | DOAJ |
| description | Ophiopogon japonicus (Thunb.) Ker Gawl., is a traditional Chinese medicine (TCM) with a history of thousands of years. O. japonicus polysaccharides (OJPs), as one of the main active ingredient, are a kind of representative pharmacological bioactive macromolecules and mainly composed of Glc and Fru with molecular weight between 2.48 and 325 kDa. OJPs have a variety of biological activities, such as hypoglycemic, cardioprotective, immunomodulatory, improvement of obesity, and renal protective activity. In this review, the extraction, purification and structural characterization of OJPs were systematically reviewed, and its biological function, molecular mechanism and structure–activity relationship were analyzed. Additionally, this review summarized and found that structural modifications such as liposome modification, sulfation modification, and polyethylene glycol modification have improved the pharmacological activity and bioavailability of OJPs. Overall, this work will help to better understand OJPs and provide a theoretical review of their further development and utilization in the field of medicine and health food. |
| format | Article |
| id | doaj-art-944ef61f69114036a724b055d77ca54d |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-944ef61f69114036a724b055d77ca54d2024-11-18T15:42:33ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-11-011110.3389/fnut.2024.14848651484865Extraction, purification, structural characterization, bioactivities, modifications and structure–activity relationship of polysaccharides from Ophiopogon japonicus: a reviewYiqiang Zhang0Bo Chen1Bo Chen2Hua Zhang3Juan Zhang4Juan Xue5Juan Xue6Department of Respiratory and Critical Medicine, Jingmen Hospital of Traditional Chinese Medicine, Jingmen, ChinaDepartment of Gastroenterology, The Second People’s Hospital of China Three Gorges University, Yichang, ChinaDepartment of Gastroenterology, The Second People’s Hospital of Yichang, Yichang, ChinaDepartment of Gastroenterology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, ChinaDepartment of Respiratory and Critical Medicine, Jingmen Hospital of Traditional Chinese Medicine, Jingmen, ChinaDepartment of Gastroenterology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, ChinaSchool of Clinical Medical, Hubei University of Chinese Medicine, Wuhan, ChinaOphiopogon japonicus (Thunb.) Ker Gawl., is a traditional Chinese medicine (TCM) with a history of thousands of years. O. japonicus polysaccharides (OJPs), as one of the main active ingredient, are a kind of representative pharmacological bioactive macromolecules and mainly composed of Glc and Fru with molecular weight between 2.48 and 325 kDa. OJPs have a variety of biological activities, such as hypoglycemic, cardioprotective, immunomodulatory, improvement of obesity, and renal protective activity. In this review, the extraction, purification and structural characterization of OJPs were systematically reviewed, and its biological function, molecular mechanism and structure–activity relationship were analyzed. Additionally, this review summarized and found that structural modifications such as liposome modification, sulfation modification, and polyethylene glycol modification have improved the pharmacological activity and bioavailability of OJPs. Overall, this work will help to better understand OJPs and provide a theoretical review of their further development and utilization in the field of medicine and health food.https://www.frontiersin.org/articles/10.3389/fnut.2024.1484865/fullOphiopogon japonicuspolysaccharidesextraction methodsstructural characterizationbiological activitiesstructure–activity relationship |
| spellingShingle | Yiqiang Zhang Bo Chen Bo Chen Hua Zhang Juan Zhang Juan Xue Juan Xue Extraction, purification, structural characterization, bioactivities, modifications and structure–activity relationship of polysaccharides from Ophiopogon japonicus: a review Frontiers in Nutrition Ophiopogon japonicus polysaccharides extraction methods structural characterization biological activities structure–activity relationship |
| title | Extraction, purification, structural characterization, bioactivities, modifications and structure–activity relationship of polysaccharides from Ophiopogon japonicus: a review |
| title_full | Extraction, purification, structural characterization, bioactivities, modifications and structure–activity relationship of polysaccharides from Ophiopogon japonicus: a review |
| title_fullStr | Extraction, purification, structural characterization, bioactivities, modifications and structure–activity relationship of polysaccharides from Ophiopogon japonicus: a review |
| title_full_unstemmed | Extraction, purification, structural characterization, bioactivities, modifications and structure–activity relationship of polysaccharides from Ophiopogon japonicus: a review |
| title_short | Extraction, purification, structural characterization, bioactivities, modifications and structure–activity relationship of polysaccharides from Ophiopogon japonicus: a review |
| title_sort | extraction purification structural characterization bioactivities modifications and structure activity relationship of polysaccharides from ophiopogon japonicus a review |
| topic | Ophiopogon japonicus polysaccharides extraction methods structural characterization biological activities structure–activity relationship |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1484865/full |
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