The aldose reductase inhibitors AT-001, AT-003 and AT-007 attenuate human keratinocyte senescence

The aldose reductase inhibitors AT-001, AT-003 and AT-007 attenuate human keratinocyte senescence

Human skin plays an important role protecting the body from both extrinsic and intrinsic factors. Skin aging at cellular level, which is a consequence of accumulation of irreparable senescent keratinocytes is associated with chronological aging. However, cell senescence may occur independent of chro...

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Bibliographic Details
Main Authors: Gautham Yepuri, Kushie Kancharla, Riccardo Perfetti, Shoshana Shendelman, Andrew Wasmuth, Ravichandran Ramasamy
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Aging
Subjects:
aldose reductase
aldose reductase inhibitors
skin cell aging
senescence
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fragi.2024.1466281/full
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https://www.frontiersin.org/articles/10.3389/fragi.2024.1466281/full

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