Effects of dietary olive oil, camellia seed oil and soybean oil on serum lipid composition in women with a high risk of cardiovascular disease: a lipidomic analysis
Numerous studies currently compare the lipid metabolism in patients with cardiovascular disease (CVD) and healthy individuals to identify lipid markers for predicting CVD. In this study, multidimensional mass spectrometry-based shotgun lipidomics was used to examine the serum lipidomics of participa...
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Tsinghua University Press
2024-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2023.9250006 |
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| author | Minyu Wu Changfeng Hu Lirong Shen |
| author_facet | Minyu Wu Changfeng Hu Lirong Shen |
| author_sort | Minyu Wu |
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| description | Numerous studies currently compare the lipid metabolism in patients with cardiovascular disease (CVD) and healthy individuals to identify lipid markers for predicting CVD. In this study, multidimensional mass spectrometry-based shotgun lipidomics was used to examine the serum lipidomics of participants in a clinical randomized controlled feeding trial undergoing olive oil (OO), camellia seed oil (CSO), and soybean oil (SO) dietary interventions. 189 lipid molecules are identified, including 14 species of phosphatidylinositol, 45 species of ethanolamine glycerols (PE), 47 species of choline glycerophospholipids (PC), 39 species of triacylglycerols (TAG), 18 species of lysophosphatidylcholine, and 26 species of sphingomyelin. After screening, 10 lipid markers are found, among which 18:2 fatty acid (FA), 16:1 FA, C54:4/C55:11, C54:3/C55:10, and C52:3/C53:10 in TAG pool, p18:0/20:0 and a18:0/18:1 in PC pool, and p18:1/20:4 in PE pool have differential regulation in the SO group compared to OO and CSO. The d16:0/18:1 in PC pool and C52:2/C53:9 in TAG pool are differentially regulated by OO and CSO. The C52:2/C53:9 in TAG pool has a significant negative correlation with aspartate aminotransferase (r = -0.363, P = 0.048) and high-density lipoprotein cholesterol (r = -0.519, P < 0.01). This study provides a reference for researching the effect of dietary fat on blood lipid metabolism. |
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| id | doaj-art-9449a629a3ca404baa4ee4d82233798a |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Tsinghua University Press |
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| series | Food Science and Human Wellness |
| spelling | doaj-art-9449a629a3ca404baa4ee4d82233798a2025-01-10T06:57:02ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-11-011363193320110.26599/FSHW.2023.9250006Effects of dietary olive oil, camellia seed oil and soybean oil on serum lipid composition in women with a high risk of cardiovascular disease: a lipidomic analysisMinyu Wu0Changfeng Hu1Lirong Shen2Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou 310058, ChinaCollege of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaDepartment of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou 310058, ChinaNumerous studies currently compare the lipid metabolism in patients with cardiovascular disease (CVD) and healthy individuals to identify lipid markers for predicting CVD. In this study, multidimensional mass spectrometry-based shotgun lipidomics was used to examine the serum lipidomics of participants in a clinical randomized controlled feeding trial undergoing olive oil (OO), camellia seed oil (CSO), and soybean oil (SO) dietary interventions. 189 lipid molecules are identified, including 14 species of phosphatidylinositol, 45 species of ethanolamine glycerols (PE), 47 species of choline glycerophospholipids (PC), 39 species of triacylglycerols (TAG), 18 species of lysophosphatidylcholine, and 26 species of sphingomyelin. After screening, 10 lipid markers are found, among which 18:2 fatty acid (FA), 16:1 FA, C54:4/C55:11, C54:3/C55:10, and C52:3/C53:10 in TAG pool, p18:0/20:0 and a18:0/18:1 in PC pool, and p18:1/20:4 in PE pool have differential regulation in the SO group compared to OO and CSO. The d16:0/18:1 in PC pool and C52:2/C53:9 in TAG pool are differentially regulated by OO and CSO. The C52:2/C53:9 in TAG pool has a significant negative correlation with aspartate aminotransferase (r = -0.363, P = 0.048) and high-density lipoprotein cholesterol (r = -0.519, P < 0.01). This study provides a reference for researching the effect of dietary fat on blood lipid metabolism.https://www.sciopen.com/article/10.26599/FSHW.2023.9250006lipidomic analysisrandomized controlled feeding trialmonounsaturated fatty acidn-6 polyunsaturated fatty acidcardiometabolic profile |
| spellingShingle | Minyu Wu Changfeng Hu Lirong Shen Effects of dietary olive oil, camellia seed oil and soybean oil on serum lipid composition in women with a high risk of cardiovascular disease: a lipidomic analysis Food Science and Human Wellness lipidomic analysis randomized controlled feeding trial monounsaturated fatty acid n-6 polyunsaturated fatty acid cardiometabolic profile |
| title | Effects of dietary olive oil, camellia seed oil and soybean oil on serum lipid composition in women with a high risk of cardiovascular disease: a lipidomic analysis |
| title_full | Effects of dietary olive oil, camellia seed oil and soybean oil on serum lipid composition in women with a high risk of cardiovascular disease: a lipidomic analysis |
| title_fullStr | Effects of dietary olive oil, camellia seed oil and soybean oil on serum lipid composition in women with a high risk of cardiovascular disease: a lipidomic analysis |
| title_full_unstemmed | Effects of dietary olive oil, camellia seed oil and soybean oil on serum lipid composition in women with a high risk of cardiovascular disease: a lipidomic analysis |
| title_short | Effects of dietary olive oil, camellia seed oil and soybean oil on serum lipid composition in women with a high risk of cardiovascular disease: a lipidomic analysis |
| title_sort | effects of dietary olive oil camellia seed oil and soybean oil on serum lipid composition in women with a high risk of cardiovascular disease a lipidomic analysis |
| topic | lipidomic analysis randomized controlled feeding trial monounsaturated fatty acid n-6 polyunsaturated fatty acid cardiometabolic profile |
| url | https://www.sciopen.com/article/10.26599/FSHW.2023.9250006 |
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