A molecular informatics and in-vitro approach to evaluate the HMG-CoA reductase inhibitory efficacy of monoterpenes, carvacrol and geraniol

A molecular informatics and in-vitro approach to evaluate the HMG-CoA reductase inhibitory efficacy of monoterpenes, carvacrol and geraniol

Currently, statins, the β-hydroxy-β-methyl-glutaryl-CoA reductase (HMG-R) inhibitors, are widely used to lower cholesterol, nevertheless, they have several side effects. Consequently, the present study is designed to unravel the cardioprotective role of selected natural monoterpenoids (carvacrol and...

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Bibliographic Details
Main Authors: Sami G. Almalki, Mohammed Alsaweed, Hind Muteb Albadrani, Yaser E. Alqurashi, Mohammed A. Bazuhair, Hamzah H. Ahmed, Parvej Ahmad, Abdulaziz Alfahed, Ayoub Al Othaim, Danish Iqbal
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Taibah University for Science
Subjects:
Atherosclerosis
hypercholesterolaemia
monoterpenes
HMG-R inhibition
enzyme kinetics
molecular docking
Online Access:https://www.tandfonline.com/doi/10.1080/16583655.2023.2297456
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