Melatonin and its physiological and therapeutic effects: A review
Melatonin, an evolutionarily old molecule, is found in many living organisms. This neurohormone is known to control many physiological processes, including circadian rhythm, mood, and behavior. Melatonin was discovered to be a direct free radical scavenger. By activating its receptors, it stimulates...
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| Format: | Article |
| Language: | English |
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University of Kragujevac, Faculty of Science
2024-01-01
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| Series: | Kragujevac Journal of Science |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1450-9636/2024/1450-96362401086S.pdf |
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| author | Stefanović Bojana V. Spasojević Nataša M. Ferizović Harisa N. Janković Milica D. Virijević Kristina M. Dronjak Slađana S. |
| author_facet | Stefanović Bojana V. Spasojević Nataša M. Ferizović Harisa N. Janković Milica D. Virijević Kristina M. Dronjak Slađana S. |
| author_sort | Stefanović Bojana V. |
| collection | DOAJ |
| description | Melatonin, an evolutionarily old molecule, is found in many living organisms. This neurohormone is known to control many physiological processes, including circadian rhythm, mood, and behavior. Melatonin was discovered to be a direct free radical scavenger. By activating its receptors, it stimulates a wide range of signaling pathways. It has been proven that melatonin exerts neuroprotective and antidepressant like effects. Also, many researchers have found that melatonin plays an important role in various cardiovascular diseases. In the near future, melatonin will be a promising agent to control the fate of mesenchymal stem cells by regulating the generation of reactive oxygen species and the release of immune factors in regenerative medicine. Collectively, the studies link melatonin to a variety of outcomes and have a strong regulatory impact on numerous physiological processes in the body. |
| format | Article |
| id | doaj-art-93e7e4bd9d35477280d654e4a17c58b6 |
| institution | Kabale University |
| issn | 1450-9636 2466-5509 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | University of Kragujevac, Faculty of Science |
| record_format | Article |
| series | Kragujevac Journal of Science |
| spelling | doaj-art-93e7e4bd9d35477280d654e4a17c58b62025-01-08T16:26:47ZengUniversity of Kragujevac, Faculty of ScienceKragujevac Journal of Science1450-96362466-55092024-01-014618612010.5937/KgJSci2400004S1450-96362401086SMelatonin and its physiological and therapeutic effects: A reviewStefanović Bojana V.0https://orcid.org/0000-0002-1360-5514Spasojević Nataša M.1https://orcid.org/0000-0001-8843-7976Ferizović Harisa N.2https://orcid.org/0000-0001-5667-7254Janković Milica D.3https://orcid.org/0000-0001-5189-9472Virijević Kristina M.4https://orcid.org/0000-0001-8848-8263Dronjak Slađana S.5https://orcid.org/0000-0002-4334-8002University of Belgrade, Institute of Nuclear Sciences "VINČA" - National Institute of the Republic of Serbia, Department of Molecular Biology and Endocrinology, Vinča, Belgrade, SerbiaUniversity of Belgrade, Institute of Nuclear Sciences "VINČA" - National Institute of the Republic of Serbia, Department of Molecular Biology and Endocrinology, Vinča, Belgrade, SerbiaUniversity of Belgrade, Institute of Nuclear Sciences "VINČA" - National Institute of the Republic of Serbia, Department of Molecular Biology and Endocrinology, Vinča, Belgrade, SerbiaUniversity of Belgrade, Institute of Nuclear Sciences "VINČA" - National Institute of the Republic of Serbia, Department of Molecular Biology and Endocrinology, Vinča, Belgrade, SerbiaUniversity of Belgrade, Institute of Nuclear Sciences "VINČA" - National Institute of the Republic of Serbia, Department of Molecular Biology and Endocrinology, Vinča, Belgrade, SerbiaUniversity of Belgrade, Institute of Nuclear Sciences "VINČA" - National Institute of the Republic of Serbia, Department of Molecular Biology and Endocrinology, Vinča, Belgrade, SerbiaMelatonin, an evolutionarily old molecule, is found in many living organisms. This neurohormone is known to control many physiological processes, including circadian rhythm, mood, and behavior. Melatonin was discovered to be a direct free radical scavenger. By activating its receptors, it stimulates a wide range of signaling pathways. It has been proven that melatonin exerts neuroprotective and antidepressant like effects. Also, many researchers have found that melatonin plays an important role in various cardiovascular diseases. In the near future, melatonin will be a promising agent to control the fate of mesenchymal stem cells by regulating the generation of reactive oxygen species and the release of immune factors in regenerative medicine. Collectively, the studies link melatonin to a variety of outcomes and have a strong regulatory impact on numerous physiological processes in the body.https://scindeks-clanci.ceon.rs/data/pdf/1450-9636/2024/1450-96362401086S.pdfmelatonincircadian rhythmdepressionneurodegenerative diseasescardiovascular system |
| spellingShingle | Stefanović Bojana V. Spasojević Nataša M. Ferizović Harisa N. Janković Milica D. Virijević Kristina M. Dronjak Slađana S. Melatonin and its physiological and therapeutic effects: A review Kragujevac Journal of Science melatonin circadian rhythm depression neurodegenerative diseases cardiovascular system |
| title | Melatonin and its physiological and therapeutic effects: A review |
| title_full | Melatonin and its physiological and therapeutic effects: A review |
| title_fullStr | Melatonin and its physiological and therapeutic effects: A review |
| title_full_unstemmed | Melatonin and its physiological and therapeutic effects: A review |
| title_short | Melatonin and its physiological and therapeutic effects: A review |
| title_sort | melatonin and its physiological and therapeutic effects a review |
| topic | melatonin circadian rhythm depression neurodegenerative diseases cardiovascular system |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1450-9636/2024/1450-96362401086S.pdf |
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