Postural imbalance without visual input is associated with specific neuropsychological deficits in older adults – results from the LIFE-adult study
IntroductionModifiable risk factors play an important role in preventing dementia and reducing its progression. Regular physical activity already in midlife, which relies on intact multisensory balance control, can help to decrease the risk of dementia. However, our understanding of the relationship...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1452150/full |
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| author | Eva Grill Andreas Zwergal Andreas Zwergal Dorothee Saur Julian Klingbeil Christopher Fricke Florian Schöberl Karim Felfela Karim Felfela Andrea Zülke Steffi Riedel-Heller Joseph Classen |
| author_facet | Eva Grill Andreas Zwergal Andreas Zwergal Dorothee Saur Julian Klingbeil Christopher Fricke Florian Schöberl Karim Felfela Karim Felfela Andrea Zülke Steffi Riedel-Heller Joseph Classen |
| author_sort | Eva Grill |
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| description | IntroductionModifiable risk factors play an important role in preventing dementia and reducing its progression. Regular physical activity already in midlife, which relies on intact multisensory balance control, can help to decrease the risk of dementia. However, our understanding of the relationship between postural balance and cognitive functions remains limited. The objective of our study was to investigate the association of postural balance during different sensory conditions with specific cognitive domains in older adults.MethodsParticipants were from the population-based prospective “Leipzig Research Center for Civilization Diseases” (LIFE-Adult) cohort in Leipzig, Germany. Executive, memory and processing speed functions were tested by the Consortium to Establish a Registry for Alzheimer’s disease (CERAD) plus battery. Assessment of visuospatial abilities was based on the short form of the Judgment of Line Orientation Test (JLO). Postural sway was recorded on a force plate with eyes open and closed. Romberg’s ratios were calculated for sway path and sway area as a proxy for balance without visual control and tested in generalized linear regression models with the summary scores of executive function, memory, processing speed and visuospatial function as dependent variables. All models were adjusted for sex, age, ApoE status, socioeconomic status, anamnestic stroke, and diabetes.ResultsIn total, we analyzed 460 participants with a mean age of 68.6 years, range 60 to 80, 47.6% female. A higher Romberg’s ratio for sway area was a significant indicator for impaired visuospatial abilities as measured by the dichotomized JLO (Odds Ratio = 1.42, 95% confidence interval 1.07 to 1.88). Romberg’s ratios were not significantly associated with executive functions, procedural speed or memory functions.DiscussionIt may be worthwhile to examine in the future whether inclusion of balance testing enhances the value of screening programs for cognitive impairment. Inversely, it may be appropriate to apply routine cognitive tests when balance problems are detected in older patients. |
| format | Article |
| id | doaj-art-93cc53cb056a470c8759be9b16583c88 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-93cc53cb056a470c8759be9b16583c882025-01-06T16:05:25ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-12-011510.3389/fneur.2024.14521501452150Postural imbalance without visual input is associated with specific neuropsychological deficits in older adults – results from the LIFE-adult studyEva Grill0Andreas Zwergal1Andreas Zwergal2Dorothee Saur3Julian Klingbeil4Christopher Fricke5Florian Schöberl6Karim Felfela7Karim Felfela8Andrea Zülke9Steffi Riedel-Heller10Joseph Classen11Institute for Medical Information Processing, Biometry, and Epidemiology, Faculty of Medicine, Ludwig-Maximilians Universität Munich, Munich, GermanyGerman Center for Vertigo and Balance Disorders, LMU University Hospital, Munich, GermanyDepartment of Neurology, LMU University Hospital, Munich, GermanyDepartment of Neurology, Leipzig University Medical Center, Leipzig, GermanyDepartment of Neurology, Leipzig University Medical Center, Leipzig, GermanyDepartment of Neurology, Leipzig University Medical Center, Leipzig, GermanyDepartment of Neurology, LMU University Hospital, Munich, GermanyGerman Center for Vertigo and Balance Disorders, LMU University Hospital, Munich, GermanyDepartment of Neurology, LMU University Hospital, Munich, GermanyInstitute for Social Medicine, Occupational Health and Public Health, Medical Faculty, University of Leipzig, Leipzig, GermanyInstitute for Social Medicine, Occupational Health and Public Health, Medical Faculty, University of Leipzig, Leipzig, GermanyDepartment of Neurology, Leipzig University Medical Center, Leipzig, GermanyIntroductionModifiable risk factors play an important role in preventing dementia and reducing its progression. Regular physical activity already in midlife, which relies on intact multisensory balance control, can help to decrease the risk of dementia. However, our understanding of the relationship between postural balance and cognitive functions remains limited. The objective of our study was to investigate the association of postural balance during different sensory conditions with specific cognitive domains in older adults.MethodsParticipants were from the population-based prospective “Leipzig Research Center for Civilization Diseases” (LIFE-Adult) cohort in Leipzig, Germany. Executive, memory and processing speed functions were tested by the Consortium to Establish a Registry for Alzheimer’s disease (CERAD) plus battery. Assessment of visuospatial abilities was based on the short form of the Judgment of Line Orientation Test (JLO). Postural sway was recorded on a force plate with eyes open and closed. Romberg’s ratios were calculated for sway path and sway area as a proxy for balance without visual control and tested in generalized linear regression models with the summary scores of executive function, memory, processing speed and visuospatial function as dependent variables. All models were adjusted for sex, age, ApoE status, socioeconomic status, anamnestic stroke, and diabetes.ResultsIn total, we analyzed 460 participants with a mean age of 68.6 years, range 60 to 80, 47.6% female. A higher Romberg’s ratio for sway area was a significant indicator for impaired visuospatial abilities as measured by the dichotomized JLO (Odds Ratio = 1.42, 95% confidence interval 1.07 to 1.88). Romberg’s ratios were not significantly associated with executive functions, procedural speed or memory functions.DiscussionIt may be worthwhile to examine in the future whether inclusion of balance testing enhances the value of screening programs for cognitive impairment. Inversely, it may be appropriate to apply routine cognitive tests when balance problems are detected in older patients.https://www.frontiersin.org/articles/10.3389/fneur.2024.1452150/fullHans Straka’s memorythe vestibular systemmild cognitive impairmentcognitionpostural balance |
| spellingShingle | Eva Grill Andreas Zwergal Andreas Zwergal Dorothee Saur Julian Klingbeil Christopher Fricke Florian Schöberl Karim Felfela Karim Felfela Andrea Zülke Steffi Riedel-Heller Joseph Classen Postural imbalance without visual input is associated with specific neuropsychological deficits in older adults – results from the LIFE-adult study Frontiers in Neurology Hans Straka’s memory the vestibular system mild cognitive impairment cognition postural balance |
| title | Postural imbalance without visual input is associated with specific neuropsychological deficits in older adults – results from the LIFE-adult study |
| title_full | Postural imbalance without visual input is associated with specific neuropsychological deficits in older adults – results from the LIFE-adult study |
| title_fullStr | Postural imbalance without visual input is associated with specific neuropsychological deficits in older adults – results from the LIFE-adult study |
| title_full_unstemmed | Postural imbalance without visual input is associated with specific neuropsychological deficits in older adults – results from the LIFE-adult study |
| title_short | Postural imbalance without visual input is associated with specific neuropsychological deficits in older adults – results from the LIFE-adult study |
| title_sort | postural imbalance without visual input is associated with specific neuropsychological deficits in older adults results from the life adult study |
| topic | Hans Straka’s memory the vestibular system mild cognitive impairment cognition postural balance |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1452150/full |
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