Post-mortem human brain analysis of the ventral pallidum in alcohol use disorder
Objective: Alcohol use disorder (AUD) is characterised by cycles of alcohol misuse, abstinence, and relapse. The neurobiology of AUD strongly implicates the role of the ventral pallidum (VP) in a variety of drugs of abuse, including alcohol. Pre-clinical studies have demonstrated critical role of pa...
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | Addiction Neuroscience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772392524000397 |
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| author | Ameer Elena Rasool Cormac Peat Jie Liu Greg Sutherland Asheeta A. Prasad |
| author_facet | Ameer Elena Rasool Cormac Peat Jie Liu Greg Sutherland Asheeta A. Prasad |
| author_sort | Ameer Elena Rasool |
| collection | DOAJ |
| description | Objective: Alcohol use disorder (AUD) is characterised by cycles of alcohol misuse, abstinence, and relapse. The neurobiology of AUD strongly implicates the role of the ventral pallidum (VP) in a variety of drugs of abuse, including alcohol. Pre-clinical studies have demonstrated critical role of parvalbumin and calretinin neurons in the VP in modulating relapse, mood, and motivation. However, there are a limited studies examining the VP at the cellular level in AUD in humans. Method: Post-mortem human brain tissue of AUD (n = 11), remission (n = 6), and control brains (n = 12) were processed for immunohistochemistry to examine the presence and changes in parvalbumin and calretinin neurons in the VP. Results: Similar to pre-clinical rodent models, parvalbumin and calretinin neurons were present in the VP, although no significant difference was found in their number or morphology across all AUD, remission, and control brains. Conclusion: The presence of parvalbumin and calretinin neurons in the VP was confirmed across all groups. This is particularly important as it supports the translatability of previous animal studies regarding the role of parvalbumin and calretinin neurons in AUD, and thus further implicates the VP in the neurobiology of AUD in humans. As there are no distinctions in the number or morphology of these neurons, their significance likely lies in their activity. The presence of both parvalbumin and calretinin in humans, particularly in both control and AUD cases supports translational capacity from preclinical findings is more feasible. |
| format | Article |
| id | doaj-art-93a06dc61ca94a32a96f390d56a8e588 |
| institution | Kabale University |
| issn | 2772-3925 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Addiction Neuroscience |
| spelling | doaj-art-93a06dc61ca94a32a96f390d56a8e5882024-11-30T07:14:39ZengElsevierAddiction Neuroscience2772-39252024-12-0113100180Post-mortem human brain analysis of the ventral pallidum in alcohol use disorderAmeer Elena Rasool0Cormac Peat1Jie Liu2Greg Sutherland3Asheeta A. Prasad4School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, AustraliaSchool of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, AustraliaSchool of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, AustraliaSchool of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, AustraliaCorresponding author.; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, AustraliaObjective: Alcohol use disorder (AUD) is characterised by cycles of alcohol misuse, abstinence, and relapse. The neurobiology of AUD strongly implicates the role of the ventral pallidum (VP) in a variety of drugs of abuse, including alcohol. Pre-clinical studies have demonstrated critical role of parvalbumin and calretinin neurons in the VP in modulating relapse, mood, and motivation. However, there are a limited studies examining the VP at the cellular level in AUD in humans. Method: Post-mortem human brain tissue of AUD (n = 11), remission (n = 6), and control brains (n = 12) were processed for immunohistochemistry to examine the presence and changes in parvalbumin and calretinin neurons in the VP. Results: Similar to pre-clinical rodent models, parvalbumin and calretinin neurons were present in the VP, although no significant difference was found in their number or morphology across all AUD, remission, and control brains. Conclusion: The presence of parvalbumin and calretinin neurons in the VP was confirmed across all groups. This is particularly important as it supports the translatability of previous animal studies regarding the role of parvalbumin and calretinin neurons in AUD, and thus further implicates the VP in the neurobiology of AUD in humans. As there are no distinctions in the number or morphology of these neurons, their significance likely lies in their activity. The presence of both parvalbumin and calretinin in humans, particularly in both control and AUD cases supports translational capacity from preclinical findings is more feasible.http://www.sciencedirect.com/science/article/pii/S2772392524000397Alcohol use disorderventral palldiumPost-mortem human brainRemissionRelapseCalretinin neurons |
| spellingShingle | Ameer Elena Rasool Cormac Peat Jie Liu Greg Sutherland Asheeta A. Prasad Post-mortem human brain analysis of the ventral pallidum in alcohol use disorder Addiction Neuroscience Alcohol use disorder ventral palldium Post-mortem human brain Remission Relapse Calretinin neurons |
| title | Post-mortem human brain analysis of the ventral pallidum in alcohol use disorder |
| title_full | Post-mortem human brain analysis of the ventral pallidum in alcohol use disorder |
| title_fullStr | Post-mortem human brain analysis of the ventral pallidum in alcohol use disorder |
| title_full_unstemmed | Post-mortem human brain analysis of the ventral pallidum in alcohol use disorder |
| title_short | Post-mortem human brain analysis of the ventral pallidum in alcohol use disorder |
| title_sort | post mortem human brain analysis of the ventral pallidum in alcohol use disorder |
| topic | Alcohol use disorder ventral palldium Post-mortem human brain Remission Relapse Calretinin neurons |
| url | http://www.sciencedirect.com/science/article/pii/S2772392524000397 |
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