Interleukin-2 receptor signaling acts as a checkpoint that influences the distribution of regulatory T cell subsets

Interleukin-2 receptor signaling acts as a checkpoint that influences the distribution of regulatory T cell subsets

Summary: Regulatory T cells (Tregs) require IL-2 for survival in the periphery, yet how IL-2 shapes Treg heterogeneity remains poorly defined. Here we show that inhibition of IL-2R signaling in post-thymic Tregs leads to a preferential early loss of circulating Tregs (cTregs). Gene expression of cTr...

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Bibliographic Details
Main Authors: Acacia N. Shouse, Alejandro V. Villarino, Thomas R. Malek
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
Biological sciences
Immune response
Immunology
Natural sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224024738
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http://www.sciencedirect.com/science/article/pii/S2589004224024738

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