Inhibition of MBTPS1 enhances antitumor immunity and potentiates anti-PD-1 immunotherapy

Abstract Despite advances in cancer immunotherapy, colorectal cancer patients exhibit limited therapeutic responses. Therefore, the exploration of strategies combining immunotherapy with adjuvant approaches to enhance adaptive immune responses is in demand. Here, we perform a customized in vivo CRIS...

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Bibliographic Details
Main Authors: Yi-Yu Wang, Jin-Fei Lin, Wen-Wei Wu, Zhe Fu, Fen Cao, Yan-Xing Chen, Hai-Yu Mo, Hui Sheng, Ze-Xian Liu, Zhao-Lei Zeng, Xin-Yuan Guan, Huai-Qiang Ju, Kun Liao, Rui-Hua Xu
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59193-4
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