Arctiin alleviates knee osteoarthritis by suppressing chondrocyte oxidative stress induced by accumulated iron via AKT/NRF2/HO-1 signaling pathway

Arctiin alleviates knee osteoarthritis by suppressing chondrocyte oxidative stress induced by accumulated iron via AKT/NRF2/HO-1 signaling pathway

Abstract Iron overload (IO) was considered to be a risk factor for cartilage degradation in knee osteoarthritis (KOA) advancement. However, few drugs were found to improve cartilage degeneration by alleviating multiple cell death induced by the impaired iron level of the knee joints. We aimed to elu...

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Bibliographic Details
Main Authors: Junzheng Yang, Delong Chen, Qi He, Baihao Chen, Zhaofeng Pan, Gangyu Zhang, Miao Li, Shaocong Li, Jiacong Xiao, Haibin Wang, Peng Chen, Zhantian An
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Herbal medicine
Cartilage degeneration
Iron overload
Apoptosis
Ferroptosis
Online Access:https://doi.org/10.1038/s41598-024-83383-7
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