Mandibular (Gnathic) osteosarcoma: Narrative review emphasizing clinical, radiological, and histopathological correlation
Background: Mandibular (Gnathic) osteosarcoma, a rare form of primary bone cancer, presents unique challenges due to its location and the essential functions of the mandible. This review aims to synthesize current knowledge on mandibular osteosarcoma, highlighting its clinical presentation, diagnost...
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Elsevier
2024-06-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S277290602400325X |
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| author | Praveen K. Sharma Iffath Misbah J.H.Shazia Fathima Ajay Lucas Rubben Jeban Chella Bruce |
| author_facet | Praveen K. Sharma Iffath Misbah J.H.Shazia Fathima Ajay Lucas Rubben Jeban Chella Bruce |
| author_sort | Praveen K. Sharma |
| collection | DOAJ |
| description | Background: Mandibular (Gnathic) osteosarcoma, a rare form of primary bone cancer, presents unique challenges due to its location and the essential functions of the mandible. This review aims to synthesize current knowledge on mandibular osteosarcoma, highlighting its clinical presentation, diagnostic challenges, and treatment strategies. Methods: A comprehensive literature review focused on recent studies and reviews on mandibular osteosarcoma. Epidemiology, clinical presentation, diagnostic methods, and advances in treatment modalities were among the main topics of study. Discussion: Mandibular osteosarcoma typically presents as a painless swelling or a painful mass in the jaw, often leading to a delayed diagnosis due to its nonspecific symptoms. Radiographic imaging plays a crucial role in diagnosis, supplemented by histopathological examination. Treatment primarily involves surgical resection, which can range from limb-sparing surgery to radical resection, depending on tumor size and location. Post-operative reconstruction is essential for restoring function and aesthetics. Chemotherapy is a critical adjunct to surgery, while radiation therapy is reserved for specific cases. The multidisciplinary approach to treatment planning is emphasized for optimal patient outcomes. Conclusion: Early diagnosis and a tailored treatment approach are essential for improving the prognosis of mandibular osteosarcoma. Improvements in adjuvant therapies and surgical procedures have improved the results of treatment. Nonetheless, the illness's rarity highlights the necessity of continued study and teamwork to comprehend and successfully treat this complicated cancer. |
| format | Article |
| id | doaj-art-92b0b47591524ae78458e444c689b153 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-92b0b47591524ae78458e444c689b1532025-01-09T06:16:28ZengElsevierOral Oncology Reports2772-90602024-06-0110100479Mandibular (Gnathic) osteosarcoma: Narrative review emphasizing clinical, radiological, and histopathological correlationPraveen K. Sharma0Iffath Misbah1J.H.Shazia Fathima2Ajay Lucas Rubben3Jeban Chella Bruce4Department of Radio-Diagnosis, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, Tamil Nadu, 602105, IndiaDepartment of Radio-Diagnosis, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, Tamil Nadu, 602105, India; Corresponding author. Department of Radio-Diagnosis Saveetha Medical College and Hospital Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, Tamil Nadu, 602105, India.CCOMManD, Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, India; Dept. of Oral Pathology and Microbiology, Ragas Dental College and Hospital, Chennai, IndiaDepartment of Radio-Diagnosis, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, Tamil Nadu, 602105, IndiaDepartment of Radio-Diagnosis, Dr.Somervell Memorial CSI Medical College, Karakonam, Thiruvananthapuram, Kerala, 695504, IndiaBackground: Mandibular (Gnathic) osteosarcoma, a rare form of primary bone cancer, presents unique challenges due to its location and the essential functions of the mandible. This review aims to synthesize current knowledge on mandibular osteosarcoma, highlighting its clinical presentation, diagnostic challenges, and treatment strategies. Methods: A comprehensive literature review focused on recent studies and reviews on mandibular osteosarcoma. Epidemiology, clinical presentation, diagnostic methods, and advances in treatment modalities were among the main topics of study. Discussion: Mandibular osteosarcoma typically presents as a painless swelling or a painful mass in the jaw, often leading to a delayed diagnosis due to its nonspecific symptoms. Radiographic imaging plays a crucial role in diagnosis, supplemented by histopathological examination. Treatment primarily involves surgical resection, which can range from limb-sparing surgery to radical resection, depending on tumor size and location. Post-operative reconstruction is essential for restoring function and aesthetics. Chemotherapy is a critical adjunct to surgery, while radiation therapy is reserved for specific cases. The multidisciplinary approach to treatment planning is emphasized for optimal patient outcomes. Conclusion: Early diagnosis and a tailored treatment approach are essential for improving the prognosis of mandibular osteosarcoma. Improvements in adjuvant therapies and surgical procedures have improved the results of treatment. Nonetheless, the illness's rarity highlights the necessity of continued study and teamwork to comprehend and successfully treat this complicated cancer.http://www.sciencedirect.com/science/article/pii/S277290602400325XMandibleOsteosarcomaBone neoplasmsComputed tomographyMagnetic resonance imaging |
| spellingShingle | Praveen K. Sharma Iffath Misbah J.H.Shazia Fathima Ajay Lucas Rubben Jeban Chella Bruce Mandibular (Gnathic) osteosarcoma: Narrative review emphasizing clinical, radiological, and histopathological correlation Oral Oncology Reports Mandible Osteosarcoma Bone neoplasms Computed tomography Magnetic resonance imaging |
| title | Mandibular (Gnathic) osteosarcoma: Narrative review emphasizing clinical, radiological, and histopathological correlation |
| title_full | Mandibular (Gnathic) osteosarcoma: Narrative review emphasizing clinical, radiological, and histopathological correlation |
| title_fullStr | Mandibular (Gnathic) osteosarcoma: Narrative review emphasizing clinical, radiological, and histopathological correlation |
| title_full_unstemmed | Mandibular (Gnathic) osteosarcoma: Narrative review emphasizing clinical, radiological, and histopathological correlation |
| title_short | Mandibular (Gnathic) osteosarcoma: Narrative review emphasizing clinical, radiological, and histopathological correlation |
| title_sort | mandibular gnathic osteosarcoma narrative review emphasizing clinical radiological and histopathological correlation |
| topic | Mandible Osteosarcoma Bone neoplasms Computed tomography Magnetic resonance imaging |
| url | http://www.sciencedirect.com/science/article/pii/S277290602400325X |
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