Monitoring of microvascular calcification by time-resolved photoacoustic microscopy
Monitoring of microvascular calcification (MC) is essential for the understanding of pathophysiological processes and the characterization of certain physiological states such as drug abuse, metabolic abnormality, and chronic nephrosis. In this work, we develop a novel and effective time-resolved ph...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Photoacoustics |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213597924000818 |
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| author | Haigang Ma Yinshi Yu Yahui Zhu Hongjun Wu Haixia Qiu Ying Gu Qian Chen Chao Zuo |
| author_facet | Haigang Ma Yinshi Yu Yahui Zhu Hongjun Wu Haixia Qiu Ying Gu Qian Chen Chao Zuo |
| author_sort | Haigang Ma |
| collection | DOAJ |
| description | Monitoring of microvascular calcification (MC) is essential for the understanding of pathophysiological processes and the characterization of certain physiological states such as drug abuse, metabolic abnormality, and chronic nephrosis. In this work, we develop a novel and effective time-resolved photoacoustic microscopy (TR-PAM) technology, which can observe the obvious microvascular bio-elastic change in the development process of the MC owing to the calcium deposition along vascular walls.The feasibility of the TR-PAM imaging was validated using a group of agar phantoms and ex vivo tissues. Furthermore, MC pathological animal models were constructed and imaged in situ and in vivo by the TR-PAM to demonstrate its capability for the bio-mechanical monitoring and characterization of MC, and experimental results were consistent with the pathological knowledge. The feasibility study of monitoring MC by the TR-PAM proves that this technique has potential to be developed as a superficial microvascular bio-mechanical assessment method to supplement current clinical strategy for prediction and monitoring of some diseases. |
| format | Article |
| id | doaj-art-928702bf44414c23b5f2076591cccdf0 |
| institution | Kabale University |
| issn | 2213-5979 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photoacoustics |
| spelling | doaj-art-928702bf44414c23b5f2076591cccdf02025-01-17T04:49:28ZengElsevierPhotoacoustics2213-59792025-02-0141100664Monitoring of microvascular calcification by time-resolved photoacoustic microscopyHaigang Ma0Yinshi Yu1Yahui Zhu2Hongjun Wu3Haixia Qiu4Ying Gu5Qian Chen6Chao Zuo7Smart Computational Imaging Laboratory (SCILab), School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China; Smart Computational Imaging Research Institute (SCIRI) of Nanjing University of Science and Technology, Nanjing, Jiangsu 210019, China; Jiangsu Key Laboratory of Spectral Imaging & Intelligent Sense, Nanjing, Jiangsu 210094, China; Corresponding authors at: Smart Computational Imaging Laboratory (SCILab), School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China.Smart Computational Imaging Laboratory (SCILab), School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China; Smart Computational Imaging Research Institute (SCIRI) of Nanjing University of Science and Technology, Nanjing, Jiangsu 210019, China; Jiangsu Key Laboratory of Spectral Imaging & Intelligent Sense, Nanjing, Jiangsu 210094, ChinaSmart Computational Imaging Laboratory (SCILab), School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China; Smart Computational Imaging Research Institute (SCIRI) of Nanjing University of Science and Technology, Nanjing, Jiangsu 210019, China; Jiangsu Key Laboratory of Spectral Imaging & Intelligent Sense, Nanjing, Jiangsu 210094, ChinaSmart Computational Imaging Laboratory (SCILab), School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China; Smart Computational Imaging Research Institute (SCIRI) of Nanjing University of Science and Technology, Nanjing, Jiangsu 210019, China; Jiangsu Key Laboratory of Spectral Imaging & Intelligent Sense, Nanjing, Jiangsu 210094, ChinaDepartment of Laser medicine, the First Medical Center of PLA General Hospital, Beijing 100853, ChinaDepartment of Laser medicine, the First Medical Center of PLA General Hospital, Beijing 100853, ChinaSmart Computational Imaging Laboratory (SCILab), School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China; Jiangsu Key Laboratory of Spectral Imaging & Intelligent Sense, Nanjing, Jiangsu 210094, ChinaSmart Computational Imaging Laboratory (SCILab), School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China; Smart Computational Imaging Research Institute (SCIRI) of Nanjing University of Science and Technology, Nanjing, Jiangsu 210019, China; Jiangsu Key Laboratory of Spectral Imaging & Intelligent Sense, Nanjing, Jiangsu 210094, China; Corresponding authors at: Smart Computational Imaging Laboratory (SCILab), School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China.Monitoring of microvascular calcification (MC) is essential for the understanding of pathophysiological processes and the characterization of certain physiological states such as drug abuse, metabolic abnormality, and chronic nephrosis. In this work, we develop a novel and effective time-resolved photoacoustic microscopy (TR-PAM) technology, which can observe the obvious microvascular bio-elastic change in the development process of the MC owing to the calcium deposition along vascular walls.The feasibility of the TR-PAM imaging was validated using a group of agar phantoms and ex vivo tissues. Furthermore, MC pathological animal models were constructed and imaged in situ and in vivo by the TR-PAM to demonstrate its capability for the bio-mechanical monitoring and characterization of MC, and experimental results were consistent with the pathological knowledge. The feasibility study of monitoring MC by the TR-PAM proves that this technique has potential to be developed as a superficial microvascular bio-mechanical assessment method to supplement current clinical strategy for prediction and monitoring of some diseases.http://www.sciencedirect.com/science/article/pii/S2213597924000818Photoacoustic microscopyMicrovascular calcificationBio-elastic monitoringBio-mechanical assessment |
| spellingShingle | Haigang Ma Yinshi Yu Yahui Zhu Hongjun Wu Haixia Qiu Ying Gu Qian Chen Chao Zuo Monitoring of microvascular calcification by time-resolved photoacoustic microscopy Photoacoustics Photoacoustic microscopy Microvascular calcification Bio-elastic monitoring Bio-mechanical assessment |
| title | Monitoring of microvascular calcification by time-resolved photoacoustic microscopy |
| title_full | Monitoring of microvascular calcification by time-resolved photoacoustic microscopy |
| title_fullStr | Monitoring of microvascular calcification by time-resolved photoacoustic microscopy |
| title_full_unstemmed | Monitoring of microvascular calcification by time-resolved photoacoustic microscopy |
| title_short | Monitoring of microvascular calcification by time-resolved photoacoustic microscopy |
| title_sort | monitoring of microvascular calcification by time resolved photoacoustic microscopy |
| topic | Photoacoustic microscopy Microvascular calcification Bio-elastic monitoring Bio-mechanical assessment |
| url | http://www.sciencedirect.com/science/article/pii/S2213597924000818 |
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