A zebrafish model of Ifih1-driven Aicardi–Goutières syndrome reproduces the interferon signature and the exacerbated inflammation of patients

A zebrafish model of Ifih1-driven Aicardi–Goutières syndrome reproduces the interferon signature and the exacerbated inflammation of patients

Type I interferonopathies are a heterogenic group of rare diseases associated with an increase in type I interferon (IFN). The main challenge for the study of Type I interferonopathies is the lack of a well-founded animal model to better characterize the phenotype as well as to perform fast and larg...

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Bibliographic Details
Main Authors: Beatriz Bernal-Bermúdez, Alicia Martínez-López, Francisco J. Martínez-Morcillo, Sylwia D. Tyrkalska, Teresa Martínez-Menchón, Pablo Mesa-del-Castillo, María L. Cayuela, Victoriano Mulero, Diana García-Moreno
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
type I IFN
IFIH1
zebrafish avatar
autoimmunity
drug screening
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1294766/full
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