Digital Quantitative Detection for Heterogeneous Protein and mRNA Expression Patterns in Circulating Tumor Cells

Digital Quantitative Detection for Heterogeneous Protein and mRNA Expression Patterns in Circulating Tumor Cells

Abstract Hepatocellular carcinoma (HCC) circulating tumor cells (CTCs) exhibit significant phenotypic heterogeneity and diverse gene expression profiles due to epithelial‐mesenchymal transition (EMT). However, current detection methods lack the capacity for simultaneous quantification of multidimens...

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Main Authors: Hao Li, Jinze Li, Zhiqi Zhang, Qi Yang, Hong Du, Qiongzhu Dong, Zhen Guo, Jia Yao, Shuli Li, Dongshu Li, Nannan Pang, Chuanyu Li, Wei Zhang, Lianqun Zhou
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
Circulating tumor cells
d‐SCOUT
HCC management
mRNAs
multi‐real‐time digital PCR
proteins
Online Access:https://doi.org/10.1002/advs.202410120
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