SAS macro programme for Bang’s Blinding Index to assess and visualise the success of blinding in randomised controlled trials
This paper aims to present a Statistical Analysis Software (SAS) macro %BBIplus, offering estimation and visualisation methods for the Bang’s Blinding Index (BBI) for randomised controlled trials (RCTs) with various designs. We developed the SAS macro programme %BBIplus to facilitate the implementat...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-12-01
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| Series: | General Psychiatry |
| Online Access: | https://gpsych.bmj.com/content/37/6/e101578.full |
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| author | Hongqiu Gu Zhen Wang Yangfeng Wu Jiani Wu Zongshi Qin Toshiaki Furukawa Yongpei Yu Dongdong Shi |
| author_facet | Hongqiu Gu Zhen Wang Yangfeng Wu Jiani Wu Zongshi Qin Toshiaki Furukawa Yongpei Yu Dongdong Shi |
| author_sort | Hongqiu Gu |
| collection | DOAJ |
| description | This paper aims to present a Statistical Analysis Software (SAS) macro %BBIplus, offering estimation and visualisation methods for the Bang’s Blinding Index (BBI) for randomised controlled trials (RCTs) with various designs. We developed the SAS macro programme %BBIplus to facilitate the implementation of BBI. This user-friendly programme allows for easy and rapid estimation and visualisation of BBI across different scenarios, including pairwise comparison RCTs with two arms, double-dummy design RCTs with three arms and factorial design RCTs with four arms. The programme requires no pre-existing data set, and users only need to input the number of individuals of correct, uncertain or wrong guesses in each intervention or control group. We illustrate the functionality of %BBIplus using blinding assessment data from three previously published RCTs: BBR (adjunctive berberine reduces antipsychotic-associated weight gain and metabolic syndrome in patients with schizophrenia: a randomised controlled trial), SELECT-TDCS (the sertraline versus electrical current therapy for treating depression clinical study: results from a factorial, randomised controlled trial) and ELECT-TDCS (trial of electrical direct-current therapy versus escitalopram for depression) studies. The programme estimates the BBI for each arm, providing point estimates, 95% CI and associated p values. Additionally, %BBIplus can visualise the estimations through forest plots and make the judgement for the success of blinding easily and rapidly. This tool caters to the needs of clinical trial investigators, offering a comprehensive solution for estimating and visualising the blinding index under various RCT designs. |
| format | Article |
| id | doaj-art-91fb6fc5384c40e7a0cddd5fd426f8d3 |
| institution | Kabale University |
| issn | 2517-729X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | General Psychiatry |
| spelling | doaj-art-91fb6fc5384c40e7a0cddd5fd426f8d32024-12-17T02:55:07ZengBMJ Publishing GroupGeneral Psychiatry2517-729X2024-12-0137610.1136/gpsych-2024-101578SAS macro programme for Bang’s Blinding Index to assess and visualise the success of blinding in randomised controlled trialsHongqiu Gu0Zhen Wang1Yangfeng Wu2Jiani Wu3Zongshi Qin4Toshiaki Furukawa5Yongpei Yu6Dongdong Shi71 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China2 Shanghai Psychological First Aid Team for Wuhan, Shanghai, China8 Clinical Research Institute and School of Public Health, Peking University, Beijing, Beijing, China4 Department of Acupuncture and Neurology, Guang`anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China2 Peking University Clinical Research Institute, Peking University, Beijing, China3Department of Health Promotion and Human Behavior, Department of Clinical Epidemiology, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, Japan1 Peking University Clinical Research Institute, Beijing, China3 Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaThis paper aims to present a Statistical Analysis Software (SAS) macro %BBIplus, offering estimation and visualisation methods for the Bang’s Blinding Index (BBI) for randomised controlled trials (RCTs) with various designs. We developed the SAS macro programme %BBIplus to facilitate the implementation of BBI. This user-friendly programme allows for easy and rapid estimation and visualisation of BBI across different scenarios, including pairwise comparison RCTs with two arms, double-dummy design RCTs with three arms and factorial design RCTs with four arms. The programme requires no pre-existing data set, and users only need to input the number of individuals of correct, uncertain or wrong guesses in each intervention or control group. We illustrate the functionality of %BBIplus using blinding assessment data from three previously published RCTs: BBR (adjunctive berberine reduces antipsychotic-associated weight gain and metabolic syndrome in patients with schizophrenia: a randomised controlled trial), SELECT-TDCS (the sertraline versus electrical current therapy for treating depression clinical study: results from a factorial, randomised controlled trial) and ELECT-TDCS (trial of electrical direct-current therapy versus escitalopram for depression) studies. The programme estimates the BBI for each arm, providing point estimates, 95% CI and associated p values. Additionally, %BBIplus can visualise the estimations through forest plots and make the judgement for the success of blinding easily and rapidly. This tool caters to the needs of clinical trial investigators, offering a comprehensive solution for estimating and visualising the blinding index under various RCT designs.https://gpsych.bmj.com/content/37/6/e101578.full |
| spellingShingle | Hongqiu Gu Zhen Wang Yangfeng Wu Jiani Wu Zongshi Qin Toshiaki Furukawa Yongpei Yu Dongdong Shi SAS macro programme for Bang’s Blinding Index to assess and visualise the success of blinding in randomised controlled trials General Psychiatry |
| title | SAS macro programme for Bang’s Blinding Index to assess and visualise the success of blinding in randomised controlled trials |
| title_full | SAS macro programme for Bang’s Blinding Index to assess and visualise the success of blinding in randomised controlled trials |
| title_fullStr | SAS macro programme for Bang’s Blinding Index to assess and visualise the success of blinding in randomised controlled trials |
| title_full_unstemmed | SAS macro programme for Bang’s Blinding Index to assess and visualise the success of blinding in randomised controlled trials |
| title_short | SAS macro programme for Bang’s Blinding Index to assess and visualise the success of blinding in randomised controlled trials |
| title_sort | sas macro programme for bang s blinding index to assess and visualise the success of blinding in randomised controlled trials |
| url | https://gpsych.bmj.com/content/37/6/e101578.full |
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