Evaluation of endothelialization of an occluder device with cardiac computed tomography and assessment of the pathological validation.
<h4>Background</h4>Assessing the endothelialization of occlusive devices noninvasively remains a challenge. Cardiac computed tomography angiography (CTA) can be employed to evaluate device endothelialization based on contrast uptake within the occluder.<h4>Objective</h4>This...
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| Format: | Article |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0316638 |
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| author | Ang Liu Xuejing Duan Ke Wang Hongguang Fan Li Li Chaowu Yan |
| author_facet | Ang Liu Xuejing Duan Ke Wang Hongguang Fan Li Li Chaowu Yan |
| author_sort | Ang Liu |
| collection | DOAJ |
| description | <h4>Background</h4>Assessing the endothelialization of occlusive devices noninvasively remains a challenge. Cardiac computed tomography angiography (CTA) can be employed to evaluate device endothelialization based on contrast uptake within the occluder.<h4>Objective</h4>This study examined device endothelialization using cardiac CTA and investigated the pathological associations.<h4>Methods</h4>From January 2010 to May 2022, we retrospectively analyzed 25 patients (age: 50.00 [17.00, 52.00] years; 12 Female) who underwent surgical device removal within 1 month after cardiac CTA examination (implantation period: 29.00[0.50, 108.00] months). The contrast uptake within the occluder was determined using cardiac CTA. The relationship between contrast uptake within the occluder and the endothelialization status with pathology was analyzed.<h4>Results</h4>Contrast uptake within the occluder was identified in 76.00% of patients. Pathological examination confirmed incomplete coverage of fibrotic tissue and superposed neoendothelium on the surface of all devices exhibiting contrast uptake. This included no coverage in 47.37% of patients and partial coverage in the remaining cases. On the surface of all devices without contrast uptake, a complete range of fibrotic tissue was observed, with an incomplete range of superposed neoendothelium in 66.67% of patients. On the surface of devices with an implantation period > 6 months, 71.43% of patients had incomplete coverage of fibrotic tissue and superposed neoendothelium on the left disc, 42.86% of patients occurred the same on the right disc.<h4>Conclusions</h4>Contrast uptake within the occluder indicated incomplete endothelialization, as confirmed by pathological validation. Late endothelialization of the device occurs frequently, and further research is required to investigate related mechanisms. |
| format | Article |
| id | doaj-art-91fb43e7f73342d6b1b3cba434e01141 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-91fb43e7f73342d6b1b3cba434e011412025-01-17T05:31:18ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031663810.1371/journal.pone.0316638Evaluation of endothelialization of an occluder device with cardiac computed tomography and assessment of the pathological validation.Ang LiuXuejing DuanKe WangHongguang FanLi LiChaowu Yan<h4>Background</h4>Assessing the endothelialization of occlusive devices noninvasively remains a challenge. Cardiac computed tomography angiography (CTA) can be employed to evaluate device endothelialization based on contrast uptake within the occluder.<h4>Objective</h4>This study examined device endothelialization using cardiac CTA and investigated the pathological associations.<h4>Methods</h4>From January 2010 to May 2022, we retrospectively analyzed 25 patients (age: 50.00 [17.00, 52.00] years; 12 Female) who underwent surgical device removal within 1 month after cardiac CTA examination (implantation period: 29.00[0.50, 108.00] months). The contrast uptake within the occluder was determined using cardiac CTA. The relationship between contrast uptake within the occluder and the endothelialization status with pathology was analyzed.<h4>Results</h4>Contrast uptake within the occluder was identified in 76.00% of patients. Pathological examination confirmed incomplete coverage of fibrotic tissue and superposed neoendothelium on the surface of all devices exhibiting contrast uptake. This included no coverage in 47.37% of patients and partial coverage in the remaining cases. On the surface of all devices without contrast uptake, a complete range of fibrotic tissue was observed, with an incomplete range of superposed neoendothelium in 66.67% of patients. On the surface of devices with an implantation period > 6 months, 71.43% of patients had incomplete coverage of fibrotic tissue and superposed neoendothelium on the left disc, 42.86% of patients occurred the same on the right disc.<h4>Conclusions</h4>Contrast uptake within the occluder indicated incomplete endothelialization, as confirmed by pathological validation. Late endothelialization of the device occurs frequently, and further research is required to investigate related mechanisms.https://doi.org/10.1371/journal.pone.0316638 |
| spellingShingle | Ang Liu Xuejing Duan Ke Wang Hongguang Fan Li Li Chaowu Yan Evaluation of endothelialization of an occluder device with cardiac computed tomography and assessment of the pathological validation. PLoS ONE |
| title | Evaluation of endothelialization of an occluder device with cardiac computed tomography and assessment of the pathological validation. |
| title_full | Evaluation of endothelialization of an occluder device with cardiac computed tomography and assessment of the pathological validation. |
| title_fullStr | Evaluation of endothelialization of an occluder device with cardiac computed tomography and assessment of the pathological validation. |
| title_full_unstemmed | Evaluation of endothelialization of an occluder device with cardiac computed tomography and assessment of the pathological validation. |
| title_short | Evaluation of endothelialization of an occluder device with cardiac computed tomography and assessment of the pathological validation. |
| title_sort | evaluation of endothelialization of an occluder device with cardiac computed tomography and assessment of the pathological validation |
| url | https://doi.org/10.1371/journal.pone.0316638 |
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