Exercise training alters resting brain-derived neurotrophic factor concentration in older adults: A systematic review with meta-analysis of randomized-controlled trials
This systematic review with meta-analysis investigated the effects of exercise training on brain-derived neurotrophic factor (BDNF) in older adults. Electronic databases of PubMed, Web of Science and Scopus were searched for studies investigating the effect of exercise training ≥4 weeks on resting B...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Experimental Gerontology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556524003048 |
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| author | Farhad Gholami Javad Mesrabadi Mohadeseh Iranpour Adel Donyaei |
| author_facet | Farhad Gholami Javad Mesrabadi Mohadeseh Iranpour Adel Donyaei |
| author_sort | Farhad Gholami |
| collection | DOAJ |
| description | This systematic review with meta-analysis investigated the effects of exercise training on brain-derived neurotrophic factor (BDNF) in older adults. Electronic databases of PubMed, Web of Science and Scopus were searched for studies investigating the effect of exercise training ≥4 weeks on resting BDNF levels in older adults. A standardized mean difference (SMD) was generated through random effects model. Thirty-five randomized-controlled trials met the inclusion criteria. Exercise training significantly increased resting BDNF levels [SMD = 0.56 (95 % CI 0.28 to 0.85)] both in plasma (SMD = 0.63) and serum (SMD = 0.54). Regarding exercise modality, aerobic (SMD = 0.48), resistance (SMD = 0.76) and combined exercise training (SMD = 0.55) increased BDNF levels. Exercise training with the duration of 12 weeks (SMD =0.65), moderate-to-vigorous (SMD = 0.83) and vigorous intensity (SMD = 0.71), and 3–4 sessions per week frequency (SMD = 0.78) yielded the largest effects on BDNF elevation. Since BDNF represents a fundamental contribution in neuronal processes and is linked to brain health, exercise training may help delay aging-related neuro-degenerative processes. Registration number: CRD42024499195. |
| format | Article |
| id | doaj-art-91e4ca1957754b11ba5ed2a66c6d2a3a |
| institution | Kabale University |
| issn | 1873-6815 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj-art-91e4ca1957754b11ba5ed2a66c6d2a3a2025-01-07T04:17:01ZengElsevierExperimental Gerontology1873-68152025-01-01199112658Exercise training alters resting brain-derived neurotrophic factor concentration in older adults: A systematic review with meta-analysis of randomized-controlled trialsFarhad Gholami0Javad Mesrabadi1Mohadeseh Iranpour2Adel Donyaei3Department of Physical Education and Sport Sciences, Faculty of Physical Education, Shahrood University of Technology, Shahrood, Semnan, Iran; Corresponding author at: Faculty of Sports Sciences, Shahrood University of Technology, Shahrood, Semnan, Iran.Department of Educational Psychology, Psychology and Educational Science Faculty, University of Azarbai-jan Shahid Madani, Tabriz, IranDepartment of Physical Education and Sport Sciences, Faculty of Physical Education, Shahrood University of Technology, Shahrood, Semnan, IranDepartment of Physical Education and Sport Sciences, Faculty of Physical Education, Shahrood University of Technology, Shahrood, Semnan, IranThis systematic review with meta-analysis investigated the effects of exercise training on brain-derived neurotrophic factor (BDNF) in older adults. Electronic databases of PubMed, Web of Science and Scopus were searched for studies investigating the effect of exercise training ≥4 weeks on resting BDNF levels in older adults. A standardized mean difference (SMD) was generated through random effects model. Thirty-five randomized-controlled trials met the inclusion criteria. Exercise training significantly increased resting BDNF levels [SMD = 0.56 (95 % CI 0.28 to 0.85)] both in plasma (SMD = 0.63) and serum (SMD = 0.54). Regarding exercise modality, aerobic (SMD = 0.48), resistance (SMD = 0.76) and combined exercise training (SMD = 0.55) increased BDNF levels. Exercise training with the duration of 12 weeks (SMD =0.65), moderate-to-vigorous (SMD = 0.83) and vigorous intensity (SMD = 0.71), and 3–4 sessions per week frequency (SMD = 0.78) yielded the largest effects on BDNF elevation. Since BDNF represents a fundamental contribution in neuronal processes and is linked to brain health, exercise training may help delay aging-related neuro-degenerative processes. Registration number: CRD42024499195.http://www.sciencedirect.com/science/article/pii/S0531556524003048BDNFAerobic trainingEndurance trainingResistance trainingExerciseAged people |
| spellingShingle | Farhad Gholami Javad Mesrabadi Mohadeseh Iranpour Adel Donyaei Exercise training alters resting brain-derived neurotrophic factor concentration in older adults: A systematic review with meta-analysis of randomized-controlled trials Experimental Gerontology BDNF Aerobic training Endurance training Resistance training Exercise Aged people |
| title | Exercise training alters resting brain-derived neurotrophic factor concentration in older adults: A systematic review with meta-analysis of randomized-controlled trials |
| title_full | Exercise training alters resting brain-derived neurotrophic factor concentration in older adults: A systematic review with meta-analysis of randomized-controlled trials |
| title_fullStr | Exercise training alters resting brain-derived neurotrophic factor concentration in older adults: A systematic review with meta-analysis of randomized-controlled trials |
| title_full_unstemmed | Exercise training alters resting brain-derived neurotrophic factor concentration in older adults: A systematic review with meta-analysis of randomized-controlled trials |
| title_short | Exercise training alters resting brain-derived neurotrophic factor concentration in older adults: A systematic review with meta-analysis of randomized-controlled trials |
| title_sort | exercise training alters resting brain derived neurotrophic factor concentration in older adults a systematic review with meta analysis of randomized controlled trials |
| topic | BDNF Aerobic training Endurance training Resistance training Exercise Aged people |
| url | http://www.sciencedirect.com/science/article/pii/S0531556524003048 |
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