Push-pull effects of basal ganglia network in Parkinson’s disease inferred by functional MRI
Abstract Deep brain stimulation (DBS) can ameliorate motor symptoms in Parkinson’s disease (PD), but its mechanism remains unclear. This work constructs a multi-scale brain model using the fMRI data from 27 PD patients with subthalamic DBS and 30 healthy controls. The model fits microscopic coupling...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-024-00835-7 |
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| _version_ | 1846158753307557888 |
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| author | Yuxin Wang Zhiqi Jiang Chunguang Chu Zhen Zhang Jiang Wang Dianyou Li Naying He Chris Fietkiewicz Changsong Zhou Marcus Kaiser Xuze Bai Chencheng Zhang Chen Liu |
| author_facet | Yuxin Wang Zhiqi Jiang Chunguang Chu Zhen Zhang Jiang Wang Dianyou Li Naying He Chris Fietkiewicz Changsong Zhou Marcus Kaiser Xuze Bai Chencheng Zhang Chen Liu |
| author_sort | Yuxin Wang |
| collection | DOAJ |
| description | Abstract Deep brain stimulation (DBS) can ameliorate motor symptoms in Parkinson’s disease (PD), but its mechanism remains unclear. This work constructs a multi-scale brain model using the fMRI data from 27 PD patients with subthalamic DBS and 30 healthy controls. The model fits microscopic coupling parameters in the cortico-basal ganglia-thalamic neural loop to match individual connectivity, finding the “push-pull” effect of basal ganglia network. Specifically, increased GABAergic projection into the thalamus from basal ganglia worsens rigidity, while reduced GABAergic projection within the cortex exacerbates bradykinesia, suggesting that the dopamine deficiency induces the chain coupling variations to “push” the network to an abnormal state. Conversely, DBS can alleviate rigidity by enhancing GABAergic projections within the basal ganglia, and improve bradykinesia by reducing cortical projections to basal ganglia, exhibiting that DBS “pulls” the network to a healthy state. This work combines the microscopic and macroscopic neural information for understanding PD and its treatment. |
| format | Article |
| id | doaj-art-91db688e5d754f749154f33b43c09f02 |
| institution | Kabale University |
| issn | 2373-8057 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-91db688e5d754f749154f33b43c09f022024-11-24T12:16:07ZengNature Portfolionpj Parkinson's Disease2373-80572024-11-0110111210.1038/s41531-024-00835-7Push-pull effects of basal ganglia network in Parkinson’s disease inferred by functional MRIYuxin Wang0Zhiqi Jiang1Chunguang Chu2Zhen Zhang3Jiang Wang4Dianyou Li5Naying He6Chris Fietkiewicz7Changsong Zhou8Marcus Kaiser9Xuze Bai10Chencheng Zhang11Chen Liu12School of Electrical and Information Engineering, Tianjin UniversitySchool of Electrical and Information Engineering, Tianjin UniversityInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan UniversitySchool of Electrical and Information Engineering, Tianjin UniversitySchool of Electrical and Information Engineering, Tianjin UniversityDepartment of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Mathematics & Computer Science, Hobart and William Smith CollegesDepartment of Physics, Hong Kong Baptist UniversityDepartment of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineSchool of Electrical and Information Engineering, Tianjin UniversityDepartment of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineSchool of Electrical and Information Engineering, Tianjin UniversityAbstract Deep brain stimulation (DBS) can ameliorate motor symptoms in Parkinson’s disease (PD), but its mechanism remains unclear. This work constructs a multi-scale brain model using the fMRI data from 27 PD patients with subthalamic DBS and 30 healthy controls. The model fits microscopic coupling parameters in the cortico-basal ganglia-thalamic neural loop to match individual connectivity, finding the “push-pull” effect of basal ganglia network. Specifically, increased GABAergic projection into the thalamus from basal ganglia worsens rigidity, while reduced GABAergic projection within the cortex exacerbates bradykinesia, suggesting that the dopamine deficiency induces the chain coupling variations to “push” the network to an abnormal state. Conversely, DBS can alleviate rigidity by enhancing GABAergic projections within the basal ganglia, and improve bradykinesia by reducing cortical projections to basal ganglia, exhibiting that DBS “pulls” the network to a healthy state. This work combines the microscopic and macroscopic neural information for understanding PD and its treatment.https://doi.org/10.1038/s41531-024-00835-7 |
| spellingShingle | Yuxin Wang Zhiqi Jiang Chunguang Chu Zhen Zhang Jiang Wang Dianyou Li Naying He Chris Fietkiewicz Changsong Zhou Marcus Kaiser Xuze Bai Chencheng Zhang Chen Liu Push-pull effects of basal ganglia network in Parkinson’s disease inferred by functional MRI npj Parkinson's Disease |
| title | Push-pull effects of basal ganglia network in Parkinson’s disease inferred by functional MRI |
| title_full | Push-pull effects of basal ganglia network in Parkinson’s disease inferred by functional MRI |
| title_fullStr | Push-pull effects of basal ganglia network in Parkinson’s disease inferred by functional MRI |
| title_full_unstemmed | Push-pull effects of basal ganglia network in Parkinson’s disease inferred by functional MRI |
| title_short | Push-pull effects of basal ganglia network in Parkinson’s disease inferred by functional MRI |
| title_sort | push pull effects of basal ganglia network in parkinson s disease inferred by functional mri |
| url | https://doi.org/10.1038/s41531-024-00835-7 |
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