FBXL16: a new regulator of neuroinflammation and cognition in Alzheimer’s disease through the ubiquitination-dependent degradation of amyloid precursor protein

FBXL16: a new regulator of neuroinflammation and cognition in Alzheimer’s disease through the ubiquitination-dependent degradation of amyloid precursor protein

Abstract Background Activating the ubiquitin-proteasome system to dismantle disease- related proteins such as tau, β-amyloid, APP, and α-synuclein is an important focus in the research of neurodegenerative proteinopathy. By analyzing the serum RNA extracted from wild-type and Alzheimer’s disease (AD...

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Bibliographic Details
Main Authors: Liqun Qu, Yong Tang, Jianhui Wu, Xiaoyun Yun, Hang Hong Lo, Linlin Song, Xingxia Wang, Huimiao Wang, Ruilong Zhang, Menghan Liu, Cairen Wang, Jerome P. L. Ng, Xianjun Fu, Io Nam Wong, Vincent Kam Wai Wong, Betty Yuen Kwan Law
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Biomarker Research
Subjects:
FBXL16
Ubiquitin
Alzheimer’s disease
Neuroprotection
Amyloid precursor protein
Online Access:https://doi.org/10.1186/s40364-024-00691-w
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