Metabolic Complete Response of Metastatic Oncogene-Negative, PDL1-Negative Non-Small Cell Lung Cancer After Chemo-Immunotherapy and Radiotherapy: A Case Report
A 71-year-old male ex-smoker presented in October 2021 to our department with a brain and bone metastatic adenocarcinoma NSCLC. PDL1, ROS, EGFR, and ALK were negative. He underwent stereotactic radiotherapy for brain metastases. In November 2021, he started a chemotherapy (CHT) regimen with cisplati...
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2024-12-01
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| Series: | Current Oncology |
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| author | Alessia Surgo Valerio Davì Maria Paola Ciliberti Roberta Carbonara Morena Caliandro Fiorella Cristina Di Guglielmo Nicola Sasso Roberto Calbi Maria Annunziata Gentile Tiziana Talienti Isabella Bruno Michele Troia Ilaria Bonaparte Giuseppe Mario Ludovico Giammarco Surico Alba Fiorentino |
| author_facet | Alessia Surgo Valerio Davì Maria Paola Ciliberti Roberta Carbonara Morena Caliandro Fiorella Cristina Di Guglielmo Nicola Sasso Roberto Calbi Maria Annunziata Gentile Tiziana Talienti Isabella Bruno Michele Troia Ilaria Bonaparte Giuseppe Mario Ludovico Giammarco Surico Alba Fiorentino |
| author_sort | Alessia Surgo |
| collection | DOAJ |
| description | A 71-year-old male ex-smoker presented in October 2021 to our department with a brain and bone metastatic adenocarcinoma NSCLC. PDL1, ROS, EGFR, and ALK were negative. He underwent stereotactic radiotherapy for brain metastases. In November 2021, he started a chemotherapy (CHT) regimen with cisplatin (75 mg/m<sup>2</sup> every 21 days) and pemetrexed (500 mg/m<sup>2</sup> every 21 days), and ICI with Atezolizumab (1200 mg every 21 days). In July 2022, RT to the lung tumor and mediastinal nodal was performed with a total dose of 45 Gy in 15 fractions. He continued with immunotherapy until December 2022, when a grade 3–4 toxicity from immunotherapy was observed (hypothyroidism, psoriasis, and cystitis). He achieved a complete clinical response to the therapy. To date, the patient is alive, with a complete metabolic response, without treatment at 37 months from diagnosis. |
| format | Article |
| id | doaj-art-91b7611fa1194d04a79907f4483cf087 |
| institution | Kabale University |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-91b7611fa1194d04a79907f4483cf0872024-12-27T14:20:06ZengMDPI AGCurrent Oncology1198-00521718-77292024-12-0131128118812610.3390/curroncol31120598Metabolic Complete Response of Metastatic Oncogene-Negative, PDL1-Negative Non-Small Cell Lung Cancer After Chemo-Immunotherapy and Radiotherapy: A Case ReportAlessia Surgo0Valerio Davì1Maria Paola Ciliberti2Roberta Carbonara3Morena Caliandro4Fiorella Cristina Di Guglielmo5Nicola Sasso6Roberto Calbi7Maria Annunziata Gentile8Tiziana Talienti9Isabella Bruno10Michele Troia11Ilaria Bonaparte12Giuseppe Mario Ludovico13Giammarco Surico14Alba Fiorentino15Radiation Oncology Department, General Regional Hospital F. Miulli, 70021 Acquaviva delle Fonti, BA, ItalyRadiation Oncology Department, General Regional Hospital F. Miulli, 70021 Acquaviva delle Fonti, BA, ItalyRadiation Oncology Department, General Regional Hospital F. Miulli, 70021 Acquaviva delle Fonti, BA, ItalyRadiation Oncology Department, General Regional Hospital F. Miulli, 70021 Acquaviva delle Fonti, BA, ItalyRadiation Oncology Department, General Regional Hospital F. Miulli, 70021 Acquaviva delle Fonti, BA, ItalyRadiation Oncology Department, General Regional Hospital F. Miulli, 70021 Acquaviva delle Fonti, BA, ItalyMedical Oncology Department, General Regional Hospital F. Miulli, 70021 Acquaviva delle Fonti, BA, ItalyRadiology Department, General Regional Hospital F. Miulli, 70021 Acquaviva delle Fonti, BA, ItalyRadiology Department, General Regional Hospital F. Miulli, 70021 Acquaviva delle Fonti, BA, ItalyRadiation Oncology Department, General Regional Hospital F. Miulli, 70021 Acquaviva delle Fonti, BA, ItalyNuclear Medicine Department, General Regional Hospital F. Miulli, 70021 Acquaviva delle Fonti, BA, ItalyPathology Department, General Regional Hospital F. Miulli, 70021 Acquaviva delle Fonti, BA, ItalyRadiation Oncology Department, General Regional Hospital F. Miulli, 70021 Acquaviva delle Fonti, BA, ItalyUrology Department, General Regional Hospital F. Miulli, 70021 Acquaviva delle Fonti, BA, ItalyMedical Oncology Department, General Regional Hospital F. Miulli, 70021 Acquaviva delle Fonti, BA, ItalyRadiation Oncology Department, General Regional Hospital F. Miulli, 70021 Acquaviva delle Fonti, BA, ItalyA 71-year-old male ex-smoker presented in October 2021 to our department with a brain and bone metastatic adenocarcinoma NSCLC. PDL1, ROS, EGFR, and ALK were negative. He underwent stereotactic radiotherapy for brain metastases. In November 2021, he started a chemotherapy (CHT) regimen with cisplatin (75 mg/m<sup>2</sup> every 21 days) and pemetrexed (500 mg/m<sup>2</sup> every 21 days), and ICI with Atezolizumab (1200 mg every 21 days). In July 2022, RT to the lung tumor and mediastinal nodal was performed with a total dose of 45 Gy in 15 fractions. He continued with immunotherapy until December 2022, when a grade 3–4 toxicity from immunotherapy was observed (hypothyroidism, psoriasis, and cystitis). He achieved a complete clinical response to the therapy. To date, the patient is alive, with a complete metabolic response, without treatment at 37 months from diagnosis.https://www.mdpi.com/1718-7729/31/12/598NSCLCbrain metastasesimmunotherapycomplete responsecase report |
| spellingShingle | Alessia Surgo Valerio Davì Maria Paola Ciliberti Roberta Carbonara Morena Caliandro Fiorella Cristina Di Guglielmo Nicola Sasso Roberto Calbi Maria Annunziata Gentile Tiziana Talienti Isabella Bruno Michele Troia Ilaria Bonaparte Giuseppe Mario Ludovico Giammarco Surico Alba Fiorentino Metabolic Complete Response of Metastatic Oncogene-Negative, PDL1-Negative Non-Small Cell Lung Cancer After Chemo-Immunotherapy and Radiotherapy: A Case Report Current Oncology NSCLC brain metastases immunotherapy complete response case report |
| title | Metabolic Complete Response of Metastatic Oncogene-Negative, PDL1-Negative Non-Small Cell Lung Cancer After Chemo-Immunotherapy and Radiotherapy: A Case Report |
| title_full | Metabolic Complete Response of Metastatic Oncogene-Negative, PDL1-Negative Non-Small Cell Lung Cancer After Chemo-Immunotherapy and Radiotherapy: A Case Report |
| title_fullStr | Metabolic Complete Response of Metastatic Oncogene-Negative, PDL1-Negative Non-Small Cell Lung Cancer After Chemo-Immunotherapy and Radiotherapy: A Case Report |
| title_full_unstemmed | Metabolic Complete Response of Metastatic Oncogene-Negative, PDL1-Negative Non-Small Cell Lung Cancer After Chemo-Immunotherapy and Radiotherapy: A Case Report |
| title_short | Metabolic Complete Response of Metastatic Oncogene-Negative, PDL1-Negative Non-Small Cell Lung Cancer After Chemo-Immunotherapy and Radiotherapy: A Case Report |
| title_sort | metabolic complete response of metastatic oncogene negative pdl1 negative non small cell lung cancer after chemo immunotherapy and radiotherapy a case report |
| topic | NSCLC brain metastases immunotherapy complete response case report |
| url | https://www.mdpi.com/1718-7729/31/12/598 |
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