Cerebellar-driven cortical dynamics can enable task acquisition, switching and consolidation
Abstract The brain must maintain a stable world model while rapidly adapting to the environment, but the underlying mechanisms are not known. Here, we posit that cortico-cerebellar loops play a key role in this process. We introduce a computational model of cerebellar networks that learn to drive co...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55315-6 |
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| _version_ | 1841559300397334528 |
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| author | Joseph Pemberton Paul Chadderton Rui Ponte Costa |
| author_facet | Joseph Pemberton Paul Chadderton Rui Ponte Costa |
| author_sort | Joseph Pemberton |
| collection | DOAJ |
| description | Abstract The brain must maintain a stable world model while rapidly adapting to the environment, but the underlying mechanisms are not known. Here, we posit that cortico-cerebellar loops play a key role in this process. We introduce a computational model of cerebellar networks that learn to drive cortical networks with task-outcome predictions. First, using sensorimotor tasks, we show that cerebellar feedback in the presence of stable cortical networks is sufficient for rapid task acquisition and switching. Next, we demonstrate that, when trained in working memory tasks, the cerebellum can also underlie the maintenance of cognitive-specific dynamics in the cortex, explaining a range of optogenetic and behavioural observations. Finally, using our model, we introduce a systems consolidation theory in which task information is gradually transferred from the cerebellum to the cortex. In summary, our findings suggest that cortico-cerebellar loops are an important component of task acquisition, switching, and consolidation in the brain. |
| format | Article |
| id | doaj-art-91ad55cf383b48149f7483d0a1caadc5 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-91ad55cf383b48149f7483d0a1caadc52025-01-05T12:36:52ZengNature PortfolioNature Communications2041-17232024-12-0115111910.1038/s41467-024-55315-6Cerebellar-driven cortical dynamics can enable task acquisition, switching and consolidationJoseph Pemberton0Paul Chadderton1Rui Ponte Costa2Computational Neuroscience Unit, Intelligent Systems Labs, Faculty of Engineering, University of BristolSchool of Physiology, Pharmacology and Neuroscience, Faculty of Life Sciences, University of BristolComputational Neuroscience Unit, Intelligent Systems Labs, Faculty of Engineering, University of BristolAbstract The brain must maintain a stable world model while rapidly adapting to the environment, but the underlying mechanisms are not known. Here, we posit that cortico-cerebellar loops play a key role in this process. We introduce a computational model of cerebellar networks that learn to drive cortical networks with task-outcome predictions. First, using sensorimotor tasks, we show that cerebellar feedback in the presence of stable cortical networks is sufficient for rapid task acquisition and switching. Next, we demonstrate that, when trained in working memory tasks, the cerebellum can also underlie the maintenance of cognitive-specific dynamics in the cortex, explaining a range of optogenetic and behavioural observations. Finally, using our model, we introduce a systems consolidation theory in which task information is gradually transferred from the cerebellum to the cortex. In summary, our findings suggest that cortico-cerebellar loops are an important component of task acquisition, switching, and consolidation in the brain.https://doi.org/10.1038/s41467-024-55315-6 |
| spellingShingle | Joseph Pemberton Paul Chadderton Rui Ponte Costa Cerebellar-driven cortical dynamics can enable task acquisition, switching and consolidation Nature Communications |
| title | Cerebellar-driven cortical dynamics can enable task acquisition, switching and consolidation |
| title_full | Cerebellar-driven cortical dynamics can enable task acquisition, switching and consolidation |
| title_fullStr | Cerebellar-driven cortical dynamics can enable task acquisition, switching and consolidation |
| title_full_unstemmed | Cerebellar-driven cortical dynamics can enable task acquisition, switching and consolidation |
| title_short | Cerebellar-driven cortical dynamics can enable task acquisition, switching and consolidation |
| title_sort | cerebellar driven cortical dynamics can enable task acquisition switching and consolidation |
| url | https://doi.org/10.1038/s41467-024-55315-6 |
| work_keys_str_mv | AT josephpemberton cerebellardrivencorticaldynamicscanenabletaskacquisitionswitchingandconsolidation AT paulchadderton cerebellardrivencorticaldynamicscanenabletaskacquisitionswitchingandconsolidation AT ruipontecosta cerebellardrivencorticaldynamicscanenabletaskacquisitionswitchingandconsolidation |