Small heterodimer partner-interacting leucine zipper protein suppresses pain and cartilage destruction in an osteoarthritis model by modulating the AMPK/STAT3 signaling pathway

Small heterodimer partner-interacting leucine zipper protein suppresses pain and cartilage destruction in an osteoarthritis model by modulating the AMPK/STAT3 signaling pathway

Abstract Objective Osteoarthritis (OA) is a degenerative joint disease caused by the breakdown of joint cartilage and adjacent bone. Joint injury, being overweight, differences in leg length, high levels of joint stress, abnormal joint or limb development, and inherited factors have been implicated...

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Main Authors: Jeonghyeon Moon, Keun-Hyung Cho, JooYeon Jhun, JeongWon Choi, Hyun-Sik Na, Jeong Su Lee, Seung Yoon Lee, Jun-Ki Min, Anan Shetty, Sung-Hwan Park, Seok Jung Kim, Mi-La Cho
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Arthritis Research & Therapy
Subjects:
Osteoarthritis (OA)
Small heterodimer partner-interacting leucine zipper protein (SMILE)
Cyclic AMP-response element binding protein Zhangfei (CREBZF)
Signal transducer and activator of transcription 3 (STAT3)
Helper T cell (th cell)
Online Access:https://doi.org/10.1186/s13075-024-03417-3
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