Diverting glial glycolytic flux towards neurons is a memory-relevant role of Drosophila CRH-like signalling
Abstract An essential role of glial cells is to comply with the large and fluctuating energy needs of neurons. Metabolic adaptation is integral to the acute stress response, suggesting that glial cells could be major, yet overlooked, targets of stress hormones. Here we show that Dh44 neuropeptide, D...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54778-x |
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| author | Raquel Francés Yasmine Rabah Thomas Preat Pierre-Yves Plaçais |
| author_facet | Raquel Francés Yasmine Rabah Thomas Preat Pierre-Yves Plaçais |
| author_sort | Raquel Francés |
| collection | DOAJ |
| description | Abstract An essential role of glial cells is to comply with the large and fluctuating energy needs of neurons. Metabolic adaptation is integral to the acute stress response, suggesting that glial cells could be major, yet overlooked, targets of stress hormones. Here we show that Dh44 neuropeptide, Drosophila homologue of mammalian corticotropin-releasing hormone (CRH), acts as an experience-dependent metabolic switch for glycolytic output in glia. Dh44 released by dopamine neurons limits glial fatty acid synthesis and build-up of lipid stores. Although basally active, this hormonal axis is acutely stimulated following learning of a danger-predictive cue. This results in transient suppression of glial anabolic use of pyruvate, sparing it for memory-relevant energy supply to neurons. Diverting pyruvate destination may dampen the need to upregulate glial glycolysis in response to increased neuronal demand. Although beneficial for the energy efficiency of memory formation, this mechanism reveals an ongoing competition between neuronal fuelling and glial anabolism. |
| format | Article |
| id | doaj-art-9169a85dbb564743a178f96ec70cd8ea |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-9169a85dbb564743a178f96ec70cd8ea2024-12-08T12:35:44ZengNature PortfolioNature Communications2041-17232024-12-0115111710.1038/s41467-024-54778-xDiverting glial glycolytic flux towards neurons is a memory-relevant role of Drosophila CRH-like signallingRaquel Francés0Yasmine Rabah1Thomas Preat2Pierre-Yves Plaçais3Energy & Memory, Brain Plasticity (UMR 8249), CNRS, ESPCI Paris, PSL Research UniversityEnergy & Memory, Brain Plasticity (UMR 8249), CNRS, ESPCI Paris, PSL Research UniversityEnergy & Memory, Brain Plasticity (UMR 8249), CNRS, ESPCI Paris, PSL Research UniversityEnergy & Memory, Brain Plasticity (UMR 8249), CNRS, ESPCI Paris, PSL Research UniversityAbstract An essential role of glial cells is to comply with the large and fluctuating energy needs of neurons. Metabolic adaptation is integral to the acute stress response, suggesting that glial cells could be major, yet overlooked, targets of stress hormones. Here we show that Dh44 neuropeptide, Drosophila homologue of mammalian corticotropin-releasing hormone (CRH), acts as an experience-dependent metabolic switch for glycolytic output in glia. Dh44 released by dopamine neurons limits glial fatty acid synthesis and build-up of lipid stores. Although basally active, this hormonal axis is acutely stimulated following learning of a danger-predictive cue. This results in transient suppression of glial anabolic use of pyruvate, sparing it for memory-relevant energy supply to neurons. Diverting pyruvate destination may dampen the need to upregulate glial glycolysis in response to increased neuronal demand. Although beneficial for the energy efficiency of memory formation, this mechanism reveals an ongoing competition between neuronal fuelling and glial anabolism.https://doi.org/10.1038/s41467-024-54778-x |
| spellingShingle | Raquel Francés Yasmine Rabah Thomas Preat Pierre-Yves Plaçais Diverting glial glycolytic flux towards neurons is a memory-relevant role of Drosophila CRH-like signalling Nature Communications |
| title | Diverting glial glycolytic flux towards neurons is a memory-relevant role of Drosophila CRH-like signalling |
| title_full | Diverting glial glycolytic flux towards neurons is a memory-relevant role of Drosophila CRH-like signalling |
| title_fullStr | Diverting glial glycolytic flux towards neurons is a memory-relevant role of Drosophila CRH-like signalling |
| title_full_unstemmed | Diverting glial glycolytic flux towards neurons is a memory-relevant role of Drosophila CRH-like signalling |
| title_short | Diverting glial glycolytic flux towards neurons is a memory-relevant role of Drosophila CRH-like signalling |
| title_sort | diverting glial glycolytic flux towards neurons is a memory relevant role of drosophila crh like signalling |
| url | https://doi.org/10.1038/s41467-024-54778-x |
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