Targeting regulated cell death (RCD) with naturally derived sesquiterpene lactones in cancer therapy
Regulated cell death (RCD) is a type of cell death modulated by specific signal transduction pathways. Currently, known RCD types include apoptosis, autophagy, ferroptosis, necroptosis, cuproptosis, pyroptosis, and NETosis. Mutations in cancer cells may prevent the RCD pathway; therefore, targeting...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661824004985 |
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| author | Cong Xu Shaodi Wen Xiaoyue Du Xinhua Zou Elaine Lai-Han Leung Guoren Zhou Qibiao Wu Bo Shen |
| author_facet | Cong Xu Shaodi Wen Xiaoyue Du Xinhua Zou Elaine Lai-Han Leung Guoren Zhou Qibiao Wu Bo Shen |
| author_sort | Cong Xu |
| collection | DOAJ |
| description | Regulated cell death (RCD) is a type of cell death modulated by specific signal transduction pathways. Currently, known RCD types include apoptosis, autophagy, ferroptosis, necroptosis, cuproptosis, pyroptosis, and NETosis. Mutations in cancer cells may prevent the RCD pathway; therefore, targeting RCD in tumors has become a promising therapeutic approach. Sesquiterpene lactones represent a diverse and extensive class of plant-derived phytochemicals that serve as potential sources for developing various drugs. Recent studies have shown that sesquiterpene lactones have promising potential in cancer treatment. This review systematically summarizes recent progress in the study of sesquiterpene lactones as antitumor agents, highlighting their role in targeting various RCD pathways, including those involved in apoptosis, autophagy, ferroptosis, necroptosis, and cuproptosis. The primary purpose of the present review is to provide a clear picture of the regulation of RCD by sesquiterpene lactones against different targets in various cancers, which will facilitate the development of new strategies for cancer therapy. |
| format | Article |
| id | doaj-art-915df5e092974bffa51e0fc1df0cd9c6 |
| institution | Kabale University |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-915df5e092974bffa51e0fc1df0cd9c62025-01-09T06:13:04ZengElsevierPharmacological Research1096-11862025-01-01211107553Targeting regulated cell death (RCD) with naturally derived sesquiterpene lactones in cancer therapyCong Xu0Shaodi Wen1Xiaoyue Du2Xinhua Zou3Elaine Lai-Han Leung4Guoren Zhou5Qibiao Wu6Bo Shen7Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing 210000, China; State Key Laboratory of Quality Research in Chinese Medicines and Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, MacaoDepartment of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing 210000, ChinaDepartment of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing 210000, ChinaDepartment of Vascular and Tumor Interventional Medicine, Affiliated Hospital of Jining Medical University, Jining 272000, ChinaCancer Center, Faculty of Health Science, University of Macau, 999078, MacaoDepartment of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing 210000, ChinaState Key Laboratory of Quality Research in Chinese Medicines and Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao; Corresponding author.Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing 210000, China; DongTai People's Hospital, Dongtai, Jiangsu, China; Corresponding author at: Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing 210000, China.Regulated cell death (RCD) is a type of cell death modulated by specific signal transduction pathways. Currently, known RCD types include apoptosis, autophagy, ferroptosis, necroptosis, cuproptosis, pyroptosis, and NETosis. Mutations in cancer cells may prevent the RCD pathway; therefore, targeting RCD in tumors has become a promising therapeutic approach. Sesquiterpene lactones represent a diverse and extensive class of plant-derived phytochemicals that serve as potential sources for developing various drugs. Recent studies have shown that sesquiterpene lactones have promising potential in cancer treatment. This review systematically summarizes recent progress in the study of sesquiterpene lactones as antitumor agents, highlighting their role in targeting various RCD pathways, including those involved in apoptosis, autophagy, ferroptosis, necroptosis, and cuproptosis. The primary purpose of the present review is to provide a clear picture of the regulation of RCD by sesquiterpene lactones against different targets in various cancers, which will facilitate the development of new strategies for cancer therapy.http://www.sciencedirect.com/science/article/pii/S1043661824004985Regulated cell death (RCD)Sesquiterpene lactonesApoptosisAutophagyFerroptosis |
| spellingShingle | Cong Xu Shaodi Wen Xiaoyue Du Xinhua Zou Elaine Lai-Han Leung Guoren Zhou Qibiao Wu Bo Shen Targeting regulated cell death (RCD) with naturally derived sesquiterpene lactones in cancer therapy Pharmacological Research Regulated cell death (RCD) Sesquiterpene lactones Apoptosis Autophagy Ferroptosis |
| title | Targeting regulated cell death (RCD) with naturally derived sesquiterpene lactones in cancer therapy |
| title_full | Targeting regulated cell death (RCD) with naturally derived sesquiterpene lactones in cancer therapy |
| title_fullStr | Targeting regulated cell death (RCD) with naturally derived sesquiterpene lactones in cancer therapy |
| title_full_unstemmed | Targeting regulated cell death (RCD) with naturally derived sesquiterpene lactones in cancer therapy |
| title_short | Targeting regulated cell death (RCD) with naturally derived sesquiterpene lactones in cancer therapy |
| title_sort | targeting regulated cell death rcd with naturally derived sesquiterpene lactones in cancer therapy |
| topic | Regulated cell death (RCD) Sesquiterpene lactones Apoptosis Autophagy Ferroptosis |
| url | http://www.sciencedirect.com/science/article/pii/S1043661824004985 |
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