Significant reduction in Hepatitis B virus infections following 32 years of universal Hepatitis B vaccination as part of EPI, Thailand
Abstract This study aimed to evaluate the impact of Thailand’s hepatitis B virus (HBV) National Program Immunization (NPI), 32 years post-implementation, on infection rates and immunity in various age groups. A cross-sectional study involved 6,068 participants aged 6 months to 80 years from four reg...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-84854-7 |
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| author | Pornjarim Nilyanimit Nasamon Wanlapakorn Preeyaporn Vichaiwattana Lakkhana Wongsrisang Sirapa Klinfueng Nungruthai Suntronwong Wichan Bhunyakitikorn Piyada Angsuwatcharakon Chaninan Sonthichai Narong Thawinwisan Pichet Puedkuntod Sunsanee Phattharasrivongchai Parichaya Loprakhon Watcharanan Tinnaitorn Thawatchai Luankaew Sasithorn Vinothai Somjet Chaijaroen Pornsawan Meechin Chalermpol Pongpichit Yong Poovorawan |
| author_facet | Pornjarim Nilyanimit Nasamon Wanlapakorn Preeyaporn Vichaiwattana Lakkhana Wongsrisang Sirapa Klinfueng Nungruthai Suntronwong Wichan Bhunyakitikorn Piyada Angsuwatcharakon Chaninan Sonthichai Narong Thawinwisan Pichet Puedkuntod Sunsanee Phattharasrivongchai Parichaya Loprakhon Watcharanan Tinnaitorn Thawatchai Luankaew Sasithorn Vinothai Somjet Chaijaroen Pornsawan Meechin Chalermpol Pongpichit Yong Poovorawan |
| author_sort | Pornjarim Nilyanimit |
| collection | DOAJ |
| description | Abstract This study aimed to evaluate the impact of Thailand’s hepatitis B virus (HBV) National Program Immunization (NPI), 32 years post-implementation, on infection rates and immunity in various age groups. A cross-sectional study involved 6,068 participants aged 6 months to 80 years from four regions in Thailand. Blood samples were tested for HBsAg, anti-HBs, and anti-HBc using a chemiluminescent immunoassay. Data were compared across age groups and with previous surveys from 2004 to 2014. Individuals born after the implementation of the NPI had significantly lower HBV infection rates (p < 0.0001). No HBsAg was detected in individuals under 20 years old. The prevalence of HBV carriers increased with age, from 0.3% in the 21–30 group to 4.3% in those over 60, with an overall prevalence of 1.7%. Percentages of seroprotected individuals (anti-HBs ≥ 10 mIU/mL) were high in young children but dropped to 19.4% in ages 11–20 and 12.5% in ages 21–30. Anti-HBc was found at very low rates in children but increased significantly after age 30. Thailand’s HBV NPI significantly reduced HBV infection rates, especially in younger populations. This study highlighted the program’s success and guided future elimination efforts to achieve hepatitis elimination goal by 2030. |
| format | Article |
| id | doaj-art-91087d2d80cf4d7e93f905e246f86329 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-91087d2d80cf4d7e93f905e246f863292025-01-12T12:18:50ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-024-84854-7Significant reduction in Hepatitis B virus infections following 32 years of universal Hepatitis B vaccination as part of EPI, ThailandPornjarim Nilyanimit0Nasamon Wanlapakorn1Preeyaporn Vichaiwattana2Lakkhana Wongsrisang3Sirapa Klinfueng4Nungruthai Suntronwong5Wichan Bhunyakitikorn6Piyada Angsuwatcharakon7Chaninan Sonthichai8Narong Thawinwisan9Pichet Puedkuntod10Sunsanee Phattharasrivongchai11Parichaya Loprakhon12Watcharanan Tinnaitorn13Thawatchai Luankaew14Sasithorn Vinothai15Somjet Chaijaroen16Pornsawan Meechin17Chalermpol Pongpichit18Yong Poovorawan19Centers of Excellence in Clinical Virology, Chulalongkorn UniversityCenters of Excellence in Clinical Virology, Chulalongkorn UniversityCenters of Excellence in Clinical Virology, Chulalongkorn UniversityCenters of Excellence in Clinical Virology, Chulalongkorn UniversityCenters of Excellence in Clinical Virology, Chulalongkorn UniversityCenters of Excellence in Clinical Virology, Chulalongkorn UniversityDivision of Communicable Diseases, Department of Disease Control, Ministry of Public HealthDivision of Communicable Diseases, Department of Disease Control, Ministry of Public HealthDivision of Communicable Diseases, Department of Disease Control, Ministry of Public HealthAyutthaya Provincial Health Office, Office of the Permanent Secretary, Ministry of Public HealthOffice of the Permanent Secretary, Buriram Provincial Health Office, Ministry of Public HealthOffice of the Permanent Secretary, Buriram Provincial Health Office, Ministry of Public HealthOffice of the Permanent Secretary, Buriram Provincial Health Office, Ministry of Public HealthOffice of the Permanent Secretary, Trang Provincial Public Health Office, Ministry of Public HealthOffice of the Permanent Secretary, Trang Provincial Public Health Office, Ministry of Public HealthOffice of the Permanent Secretary, Trang Provincial Public Health Office, Ministry of Public HealthUttaradit HospitalFaktha HospitalThongsaenkhan HospitalCenters of Excellence in Clinical Virology, Chulalongkorn UniversityAbstract This study aimed to evaluate the impact of Thailand’s hepatitis B virus (HBV) National Program Immunization (NPI), 32 years post-implementation, on infection rates and immunity in various age groups. A cross-sectional study involved 6,068 participants aged 6 months to 80 years from four regions in Thailand. Blood samples were tested for HBsAg, anti-HBs, and anti-HBc using a chemiluminescent immunoassay. Data were compared across age groups and with previous surveys from 2004 to 2014. Individuals born after the implementation of the NPI had significantly lower HBV infection rates (p < 0.0001). No HBsAg was detected in individuals under 20 years old. The prevalence of HBV carriers increased with age, from 0.3% in the 21–30 group to 4.3% in those over 60, with an overall prevalence of 1.7%. Percentages of seroprotected individuals (anti-HBs ≥ 10 mIU/mL) were high in young children but dropped to 19.4% in ages 11–20 and 12.5% in ages 21–30. Anti-HBc was found at very low rates in children but increased significantly after age 30. Thailand’s HBV NPI significantly reduced HBV infection rates, especially in younger populations. This study highlighted the program’s success and guided future elimination efforts to achieve hepatitis elimination goal by 2030.https://doi.org/10.1038/s41598-024-84854-7Hepatitis B vaccinationNational Program Immunization (NPI)HBV infection ratesHBsAg prevalenceHepatitis B elimination |
| spellingShingle | Pornjarim Nilyanimit Nasamon Wanlapakorn Preeyaporn Vichaiwattana Lakkhana Wongsrisang Sirapa Klinfueng Nungruthai Suntronwong Wichan Bhunyakitikorn Piyada Angsuwatcharakon Chaninan Sonthichai Narong Thawinwisan Pichet Puedkuntod Sunsanee Phattharasrivongchai Parichaya Loprakhon Watcharanan Tinnaitorn Thawatchai Luankaew Sasithorn Vinothai Somjet Chaijaroen Pornsawan Meechin Chalermpol Pongpichit Yong Poovorawan Significant reduction in Hepatitis B virus infections following 32 years of universal Hepatitis B vaccination as part of EPI, Thailand Scientific Reports Hepatitis B vaccination National Program Immunization (NPI) HBV infection rates HBsAg prevalence Hepatitis B elimination |
| title | Significant reduction in Hepatitis B virus infections following 32 years of universal Hepatitis B vaccination as part of EPI, Thailand |
| title_full | Significant reduction in Hepatitis B virus infections following 32 years of universal Hepatitis B vaccination as part of EPI, Thailand |
| title_fullStr | Significant reduction in Hepatitis B virus infections following 32 years of universal Hepatitis B vaccination as part of EPI, Thailand |
| title_full_unstemmed | Significant reduction in Hepatitis B virus infections following 32 years of universal Hepatitis B vaccination as part of EPI, Thailand |
| title_short | Significant reduction in Hepatitis B virus infections following 32 years of universal Hepatitis B vaccination as part of EPI, Thailand |
| title_sort | significant reduction in hepatitis b virus infections following 32 years of universal hepatitis b vaccination as part of epi thailand |
| topic | Hepatitis B vaccination National Program Immunization (NPI) HBV infection rates HBsAg prevalence Hepatitis B elimination |
| url | https://doi.org/10.1038/s41598-024-84854-7 |
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