Metabolomics of mothers of children with autism, idiopathic developmental delay, and Down syndrome
Abstract Developmental delays have been associated with metabolic disturbances in children. Previous research in the childhood autism risk from genetics and the environment (CHARGE) case–control study identified neurodevelopment-related plasma metabolites in children, suggesting disturbances in the...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-12-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-83587-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559450099384320 |
|---|---|
| author | Mariana Parenti Shannon Shoff Jennie Sotelo-Orozco Irva Hertz-Picciotto Carolyn M. Slupsky |
| author_facet | Mariana Parenti Shannon Shoff Jennie Sotelo-Orozco Irva Hertz-Picciotto Carolyn M. Slupsky |
| author_sort | Mariana Parenti |
| collection | DOAJ |
| description | Abstract Developmental delays have been associated with metabolic disturbances in children. Previous research in the childhood autism risk from genetics and the environment (CHARGE) case–control study identified neurodevelopment-related plasma metabolites in children, suggesting disturbances in the energy-related tricarboxylic acid (TCA) cycle and 1-carbon metabolism (1CM). Here, we investigated associations between children’s neurodevelopmental outcomes and their mothers’ plasma metabolite profiles in a subset of mother–child dyads from CHARGE, including those with autism spectrum disorder (ASD, n = 209), Down syndrome (DS, n = 76), idiopathic developmental delay (iDD, n = 64), and typically developed (TD, n = 185) controls. Multiple linear regression revealed associations between child neurodevelopmental outcomes and maternal plasma metabolites related to the TCA cycle, 1CM, and lipid metabolism. Despite profound metabolic disturbances in children with DS reported previously, few of these differences were observed in the mothers, which might reflect differences in gene dosage between children with DS and their euploid mothers. Notably differences in maternal metabolism related to ASD and iDD followed similar patterns of disturbance in previously reported metabolic signatures in children but were generally smaller in magnitude. Similar patterns of metabolic disturbances observed in mothers and their children with ASD or iDD could reflect shared genetic, mitochondrial, and/or environmental risk factors. |
| format | Article |
| id | doaj-art-90ff4fa8ff424be5a4f6f1e80daf4dca |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-90ff4fa8ff424be5a4f6f1e80daf4dca2025-01-05T12:29:47ZengNature PortfolioScientific Reports2045-23222024-12-011411910.1038/s41598-024-83587-xMetabolomics of mothers of children with autism, idiopathic developmental delay, and Down syndromeMariana Parenti0Shannon Shoff1Jennie Sotelo-Orozco2Irva Hertz-Picciotto3Carolyn M. Slupsky4Department of Nutrition, Department of Food Science and Technology, University of CaliforniaDepartment of Nutrition, Department of Food Science and Technology, University of CaliforniaDepartment of Public Health Sciences, University of CaliforniaDepartment of Public Health Sciences, University of CaliforniaDepartment of Nutrition, Department of Food Science and Technology, University of CaliforniaAbstract Developmental delays have been associated with metabolic disturbances in children. Previous research in the childhood autism risk from genetics and the environment (CHARGE) case–control study identified neurodevelopment-related plasma metabolites in children, suggesting disturbances in the energy-related tricarboxylic acid (TCA) cycle and 1-carbon metabolism (1CM). Here, we investigated associations between children’s neurodevelopmental outcomes and their mothers’ plasma metabolite profiles in a subset of mother–child dyads from CHARGE, including those with autism spectrum disorder (ASD, n = 209), Down syndrome (DS, n = 76), idiopathic developmental delay (iDD, n = 64), and typically developed (TD, n = 185) controls. Multiple linear regression revealed associations between child neurodevelopmental outcomes and maternal plasma metabolites related to the TCA cycle, 1CM, and lipid metabolism. Despite profound metabolic disturbances in children with DS reported previously, few of these differences were observed in the mothers, which might reflect differences in gene dosage between children with DS and their euploid mothers. Notably differences in maternal metabolism related to ASD and iDD followed similar patterns of disturbance in previously reported metabolic signatures in children but were generally smaller in magnitude. Similar patterns of metabolic disturbances observed in mothers and their children with ASD or iDD could reflect shared genetic, mitochondrial, and/or environmental risk factors.https://doi.org/10.1038/s41598-024-83587-x |
| spellingShingle | Mariana Parenti Shannon Shoff Jennie Sotelo-Orozco Irva Hertz-Picciotto Carolyn M. Slupsky Metabolomics of mothers of children with autism, idiopathic developmental delay, and Down syndrome Scientific Reports |
| title | Metabolomics of mothers of children with autism, idiopathic developmental delay, and Down syndrome |
| title_full | Metabolomics of mothers of children with autism, idiopathic developmental delay, and Down syndrome |
| title_fullStr | Metabolomics of mothers of children with autism, idiopathic developmental delay, and Down syndrome |
| title_full_unstemmed | Metabolomics of mothers of children with autism, idiopathic developmental delay, and Down syndrome |
| title_short | Metabolomics of mothers of children with autism, idiopathic developmental delay, and Down syndrome |
| title_sort | metabolomics of mothers of children with autism idiopathic developmental delay and down syndrome |
| url | https://doi.org/10.1038/s41598-024-83587-x |
| work_keys_str_mv | AT marianaparenti metabolomicsofmothersofchildrenwithautismidiopathicdevelopmentaldelayanddownsyndrome AT shannonshoff metabolomicsofmothersofchildrenwithautismidiopathicdevelopmentaldelayanddownsyndrome AT jenniesoteloorozco metabolomicsofmothersofchildrenwithautismidiopathicdevelopmentaldelayanddownsyndrome AT irvahertzpicciotto metabolomicsofmothersofchildrenwithautismidiopathicdevelopmentaldelayanddownsyndrome AT carolynmslupsky metabolomicsofmothersofchildrenwithautismidiopathicdevelopmentaldelayanddownsyndrome |