Ketogenesis promotes triple-negative breast cancer metastasis via calpastatin β-hydroxybutyrylation

Ketogenesis promotes triple-negative breast cancer metastasis via calpastatin β-hydroxybutyrylation

Abstract Triple-negative breast cancer (TNBC) continues to pose a significant obstacle in the field of oncology. Dysregulation of lipid metabolism, notably upregulated ketogenesis, has emerged as a hallmark of TNBC, yet its role in metastasis has been elusive. Here, by utilizing clinical specimens a...

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Bibliographic Details
Main Authors: Haoran Jiang, Yuan Zeng, Xiaoye Yuan, Liwen Chen, Xuni Xu, Xue Jiang, Quan Li, Gang Li, Han Yang
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Lipids in Health and Disease
Subjects:
Breast cancer
Metastasis
Ketogenesis
β-hydroxybutyrylation
Epithelial–mesenchymal transition
Online Access:https://doi.org/10.1186/s12944-024-02364-x
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