Evaluation of Antidiabetic, Renoprotective, and Antioxidant Properties of Aqueous Extracts of Linum usitatissimum in Streptozotocin-Induced Diabetic Rats
Introduction: Diabetes is a common metabolic disorder having the phenotype of hyperglycemia. Linum usitatissimum is a blue or purple flowering crop whose consumption has also shown a decrease in postprandial glucose absorption, improvement in glucose tolerance, and serum cholesterol levels. Aim: Thi...
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Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2023-03-01
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Series: | Medical Journal of Dr. D.Y. Patil Vidyapeeth |
Subjects: | |
Online Access: | https://journals.lww.com/10.4103/mjdrdypu.mjdrdypu_693_22 |
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Summary: | Introduction:
Diabetes is a common metabolic disorder having the phenotype of hyperglycemia. Linum usitatissimum is a blue or purple flowering crop whose consumption has also shown a decrease in postprandial glucose absorption, improvement in glucose tolerance, and serum cholesterol levels.
Aim:
This study was taken up to evaluate the antiglycemic, renoprotective, and antioxidant effect of various doses of Linum usitatissimum in diabetes so that various long-term complications of the disease could be controlled and minimized.
Study Design:
The study was conducted for the period of 2 months in the Department of Pharmacology KIMS, Bhubaneswar. A total of 30 albino Wistar rats were taken and divided into five groups containing six rats each. Experimental diabetes was induced in rats by administering a single intraperitoneal injection of streptozotocin in overnight-fasted rats. Group I was diabetic control, Group II was treatment control, and Group III to V rats were given different doses of the extract. Blood samples were taken at the end of 2 months.
Results:
All the values are expressed as means ± SD. Significant decrease in glycemic parameters, urea, creatinine, and oxidative stress levels were seen at the end of 2 months in all three groups receiving the extract, where the highest dose of extract did maximum reduction, which is comparable with the standard drug.
Conclusion:
From our study, it can be concluded that there was a significant reduction in glycemic parameters as well as the plant extracts possess excellent renoprotective and antioxidant property, therefore flax seeds are efficient in reducing the long-term complications of diabetes. |
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ISSN: | 2589-8302 2589-8310 |