Evaluation of bone mineral density and its influencing factors in patients infected with HIV under antiretroviral therapy
Abstract Background Reduced Bone Mineral Density (BMD) has been linked to Human Immunodeficiency Virus (HIV) infection and treatment. There is a lack of information regarding the osteoporosis status of middle-aged patients with HIV in Iran, despite the fact that Antiretroviral Therapy (ART) is widel...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-024-10388-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841544986779189248 |
|---|---|
| author | Alireza Azarboo Mahboobeh Hemmatabadi Noushin Fahimfar Zahra Faghihi SeyedAhmad SeyedAlinaghi Nooshin Shirzad Ladan Abbasian |
| author_facet | Alireza Azarboo Mahboobeh Hemmatabadi Noushin Fahimfar Zahra Faghihi SeyedAhmad SeyedAlinaghi Nooshin Shirzad Ladan Abbasian |
| author_sort | Alireza Azarboo |
| collection | DOAJ |
| description | Abstract Background Reduced Bone Mineral Density (BMD) has been linked to Human Immunodeficiency Virus (HIV) infection and treatment. There is a lack of information regarding the osteoporosis status of middle-aged patients with HIV in Iran, despite the fact that Antiretroviral Therapy (ART) is widely accessible. Objective The purpose of this cross-sectional study was to assess the BMD status and low BMD risk factors in patients with HIV under ART living in Iran. Methods Data were collected from individuals diagnosed with HIV aged 30–50, receiving ART for at least 6 months. Dual-energy X-ray absorptiometry scans assessed BMD in femoral neck, total hip, and lumbar regions. Pearson’s correlation coefficients identified relationships between BMD and demographic and laboratory predictors. Univariable and multivariable logistic regression models assessed predictors of low lumbar BMD. Results Among 80 HIV-infected individuals (mean age: 41.1 ± 5.6 years, 60.4% male), 15% exhibited low BMD in the lumbar spine and 3.75% in the femoral neck. Serum phosphate levels were negatively correlated with BMD across the femoral neck, total hip, and lumbar regions (e.g., lumbar BMD: r = -0.24, p = 0.03). Parathyroid hormone (PTH) showed negative correlations with femoral neck and total hip BMD (r = -0.26, p = 0.01; r = -0.29, p = 0.01, respectively). Estradiol positively correlated with lumbar BMD in females (r = 0.36, p = 0.04), and BMI positively correlated with BMD in all regions (e.g., lumbar: r = 0.41, p = 0.001). Testosterone was inversely associated with the odds of lumbar low BMD (OR [95% CI] = 0.79 [0.62–0.96], p = 0.02). Duration of HIV or treatment, CD4 levels, and viral load were not significantly associated with BMD. Conclusion This study highlights the multifactorial nature of BMD changes in individuals living with HIV. By identifying correlations between metabolic, hormonal, and disease-related factors and bone health, our findings bring attention to an often-overlooked aspect of HIV management, that is patients with HIV may benefit from routine BMD screening, as it could help identify early risks of low BMD. |
| format | Article |
| id | doaj-art-904c53d212c84380861b9fc7b1136ea0 |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-904c53d212c84380861b9fc7b1136ea02025-01-12T12:09:29ZengBMCBMC Infectious Diseases1471-23342025-01-012511910.1186/s12879-024-10388-yEvaluation of bone mineral density and its influencing factors in patients infected with HIV under antiretroviral therapyAlireza Azarboo0Mahboobeh Hemmatabadi1Noushin Fahimfar2Zahra Faghihi3SeyedAhmad SeyedAlinaghi4Nooshin Shirzad5Ladan Abbasian6Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesDepartment of Endocrinology, Endocrinology, and Metabolism Research Center, Vali-Asr Hospital, Imam Khomeini Complex Hospital, Tehran University of Medical SciencesOsteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesDepartment of Endocrinology, Endocrinology, and Metabolism Research Center, Vali-Asr Hospital, Imam Khomeini Complex Hospital, Tehran University of Medical SciencesDepartment of Infectious Diseases, School of Medicine, Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Imam Khomeini Hospital Complex, Tehran University of Medical SciencesOsteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesDepartment of Infectious Diseases, School of Medicine, Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Imam Khomeini Hospital Complex, Tehran University of Medical SciencesAbstract Background Reduced Bone Mineral Density (BMD) has been linked to Human Immunodeficiency Virus (HIV) infection and treatment. There is a lack of information regarding the osteoporosis status of middle-aged patients with HIV in Iran, despite the fact that Antiretroviral Therapy (ART) is widely accessible. Objective The purpose of this cross-sectional study was to assess the BMD status and low BMD risk factors in patients with HIV under ART living in Iran. Methods Data were collected from individuals diagnosed with HIV aged 30–50, receiving ART for at least 6 months. Dual-energy X-ray absorptiometry scans assessed BMD in femoral neck, total hip, and lumbar regions. Pearson’s correlation coefficients identified relationships between BMD and demographic and laboratory predictors. Univariable and multivariable logistic regression models assessed predictors of low lumbar BMD. Results Among 80 HIV-infected individuals (mean age: 41.1 ± 5.6 years, 60.4% male), 15% exhibited low BMD in the lumbar spine and 3.75% in the femoral neck. Serum phosphate levels were negatively correlated with BMD across the femoral neck, total hip, and lumbar regions (e.g., lumbar BMD: r = -0.24, p = 0.03). Parathyroid hormone (PTH) showed negative correlations with femoral neck and total hip BMD (r = -0.26, p = 0.01; r = -0.29, p = 0.01, respectively). Estradiol positively correlated with lumbar BMD in females (r = 0.36, p = 0.04), and BMI positively correlated with BMD in all regions (e.g., lumbar: r = 0.41, p = 0.001). Testosterone was inversely associated with the odds of lumbar low BMD (OR [95% CI] = 0.79 [0.62–0.96], p = 0.02). Duration of HIV or treatment, CD4 levels, and viral load were not significantly associated with BMD. Conclusion This study highlights the multifactorial nature of BMD changes in individuals living with HIV. By identifying correlations between metabolic, hormonal, and disease-related factors and bone health, our findings bring attention to an often-overlooked aspect of HIV management, that is patients with HIV may benefit from routine BMD screening, as it could help identify early risks of low BMD.https://doi.org/10.1186/s12879-024-10388-yHIVBone mineral densityAntiretroviral therapyOsteoporosisRisk factors |
| spellingShingle | Alireza Azarboo Mahboobeh Hemmatabadi Noushin Fahimfar Zahra Faghihi SeyedAhmad SeyedAlinaghi Nooshin Shirzad Ladan Abbasian Evaluation of bone mineral density and its influencing factors in patients infected with HIV under antiretroviral therapy BMC Infectious Diseases HIV Bone mineral density Antiretroviral therapy Osteoporosis Risk factors |
| title | Evaluation of bone mineral density and its influencing factors in patients infected with HIV under antiretroviral therapy |
| title_full | Evaluation of bone mineral density and its influencing factors in patients infected with HIV under antiretroviral therapy |
| title_fullStr | Evaluation of bone mineral density and its influencing factors in patients infected with HIV under antiretroviral therapy |
| title_full_unstemmed | Evaluation of bone mineral density and its influencing factors in patients infected with HIV under antiretroviral therapy |
| title_short | Evaluation of bone mineral density and its influencing factors in patients infected with HIV under antiretroviral therapy |
| title_sort | evaluation of bone mineral density and its influencing factors in patients infected with hiv under antiretroviral therapy |
| topic | HIV Bone mineral density Antiretroviral therapy Osteoporosis Risk factors |
| url | https://doi.org/10.1186/s12879-024-10388-y |
| work_keys_str_mv | AT alirezaazarboo evaluationofbonemineraldensityanditsinfluencingfactorsinpatientsinfectedwithhivunderantiretroviraltherapy AT mahboobehhemmatabadi evaluationofbonemineraldensityanditsinfluencingfactorsinpatientsinfectedwithhivunderantiretroviraltherapy AT noushinfahimfar evaluationofbonemineraldensityanditsinfluencingfactorsinpatientsinfectedwithhivunderantiretroviraltherapy AT zahrafaghihi evaluationofbonemineraldensityanditsinfluencingfactorsinpatientsinfectedwithhivunderantiretroviraltherapy AT seyedahmadseyedalinaghi evaluationofbonemineraldensityanditsinfluencingfactorsinpatientsinfectedwithhivunderantiretroviraltherapy AT nooshinshirzad evaluationofbonemineraldensityanditsinfluencingfactorsinpatientsinfectedwithhivunderantiretroviraltherapy AT ladanabbasian evaluationofbonemineraldensityanditsinfluencingfactorsinpatientsinfectedwithhivunderantiretroviraltherapy |