Association of calf circumference with osteoporosis and hip fracture in middle-aged and older adults: a secondary analysis
Abstract Background Osteosarcopenia is a geriatric syndrome associated with an increased risk of frailty, falls, fractures, disability, and death. Calf circumference (CC) has been used as a simple and practical skeletal muscle marker to diagnose sarcopenia. This study aimed to explore the relationsh...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-12-01
|
| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-024-08237-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559894555099136 |
|---|---|
| author | Mumin Cao Yuanwei Zhang Mengze Tong Xiangxu Chen Ziang Xu Renwang Sheng Liu Shi Cheng Zhang Wenbin Fan Tian Xie Yingjuan Li Jinyu Wang Wei Gao Yunfeng Rui |
| author_facet | Mumin Cao Yuanwei Zhang Mengze Tong Xiangxu Chen Ziang Xu Renwang Sheng Liu Shi Cheng Zhang Wenbin Fan Tian Xie Yingjuan Li Jinyu Wang Wei Gao Yunfeng Rui |
| author_sort | Mumin Cao |
| collection | DOAJ |
| description | Abstract Background Osteosarcopenia is a geriatric syndrome associated with an increased risk of frailty, falls, fractures, disability, and death. Calf circumference (CC) has been used as a simple and practical skeletal muscle marker to diagnose sarcopenia. This study aimed to explore the relationship of calf circumference and osteoporosis (OP) and hip fractures (HF) in middle-aged and older adults. This is important for screening OP and HF in the community and improving the quality of life of older adults. Methods This study was based on the National Health and Nutrition Examination Survey (NHANES) 1999–2006. Logistic regression analysis and restricted cubic spline were used to investigate the correlation of CC with OP and HF. The receiver operating characteristic (ROC) curve was utilized to determine the optimal cut-off value for CC. Finally, logistic regression model analysis was applied to test the predictive efficacy of CC. Results Among 4575 individuals with a mean age of 63.0 ± 11.5 years, the OP group had higher proportions of females (P < 0.001) and non-Hispanic whites (P < 0.001). Logistic regression and RCS demonstrated that lower CC was associated with a greater risk of OP and HF in the female group (P < 0.001). ROC curves showed that CC of 33.65 cm and 33.85 cm were the best cut-off values for predicting OP and HF in middle-aged and older females. Logistic regression analyses found good predictive efficacy for cut-off values of CC in females. Conclusion In middle-aged and older women, low CC is associated with a higher risk of OP and HF. These findings have important implications for managing osteosarcopenia and associated fractures in older adults. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-90384850761440e7b100ae0e0693c018 |
| institution | Kabale University |
| issn | 1471-2474 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj-art-90384850761440e7b100ae0e0693c0182025-01-05T12:04:43ZengBMCBMC Musculoskeletal Disorders1471-24742024-12-0125111110.1186/s12891-024-08237-9Association of calf circumference with osteoporosis and hip fracture in middle-aged and older adults: a secondary analysisMumin Cao0Yuanwei Zhang1Mengze Tong2Xiangxu Chen3Ziang Xu4Renwang Sheng5Liu Shi6Cheng Zhang7Wenbin Fan8Tian Xie9Yingjuan Li10Jinyu Wang11Wei Gao12Yunfeng Rui13Department of Orthopaedics, School of Medicine, Zhongda Hospital, Southeast UniversityDepartment of Orthopaedics, Xinhua Hospital, Shanghai JiaoTong University School of MedicineSchool of Medicine, Southeast UniversityDepartment of Orthopaedics, School of Medicine, Zhongda Hospital, Southeast UniversityState Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical UniversityDepartment of Orthopaedics, School of Medicine, Zhongda Hospital, Southeast UniversityDepartment of Orthopaedics, School of Medicine, Zhongda Hospital, Southeast UniversityDepartment of Orthopaedics, School of Medicine, Zhongda Hospital, Southeast UniversityDepartment of Orthopaedics, School of Medicine, Zhongda Hospital, Southeast UniversityDepartment of Orthopaedics, School of Medicine, Zhongda Hospital, Southeast UniversityMultidisciplinary Team (MDT) for Geriatric Hip Fracture Management, School of Medicine, Zhongda Hospital, Southeast UniversityMultidisciplinary Team (MDT) for Geriatric Hip Fracture Management, School of Medicine, Zhongda Hospital, Southeast UniversityMultidisciplinary Team (MDT) for Geriatric Hip Fracture Management, School of Medicine, Zhongda Hospital, Southeast UniversityDepartment of Orthopaedics, School of Medicine, Zhongda Hospital, Southeast UniversityAbstract Background Osteosarcopenia is a geriatric syndrome associated with an increased risk of frailty, falls, fractures, disability, and death. Calf circumference (CC) has been used as a simple and practical skeletal muscle marker to diagnose sarcopenia. This study aimed to explore the relationship of calf circumference and osteoporosis (OP) and hip fractures (HF) in middle-aged and older adults. This is important for screening OP and HF in the community and improving the quality of life of older adults. Methods This study was based on the National Health and Nutrition Examination Survey (NHANES) 1999–2006. Logistic regression analysis and restricted cubic spline were used to investigate the correlation of CC with OP and HF. The receiver operating characteristic (ROC) curve was utilized to determine the optimal cut-off value for CC. Finally, logistic regression model analysis was applied to test the predictive efficacy of CC. Results Among 4575 individuals with a mean age of 63.0 ± 11.5 years, the OP group had higher proportions of females (P < 0.001) and non-Hispanic whites (P < 0.001). Logistic regression and RCS demonstrated that lower CC was associated with a greater risk of OP and HF in the female group (P < 0.001). ROC curves showed that CC of 33.65 cm and 33.85 cm were the best cut-off values for predicting OP and HF in middle-aged and older females. Logistic regression analyses found good predictive efficacy for cut-off values of CC in females. Conclusion In middle-aged and older women, low CC is associated with a higher risk of OP and HF. These findings have important implications for managing osteosarcopenia and associated fractures in older adults. Clinical trial number Not applicable.https://doi.org/10.1186/s12891-024-08237-9OsteoporosisHip fractureCalf circumferenceSarcopeniaOsteosarcopeniaOlder adults |
| spellingShingle | Mumin Cao Yuanwei Zhang Mengze Tong Xiangxu Chen Ziang Xu Renwang Sheng Liu Shi Cheng Zhang Wenbin Fan Tian Xie Yingjuan Li Jinyu Wang Wei Gao Yunfeng Rui Association of calf circumference with osteoporosis and hip fracture in middle-aged and older adults: a secondary analysis BMC Musculoskeletal Disorders Osteoporosis Hip fracture Calf circumference Sarcopenia Osteosarcopenia Older adults |
| title | Association of calf circumference with osteoporosis and hip fracture in middle-aged and older adults: a secondary analysis |
| title_full | Association of calf circumference with osteoporosis and hip fracture in middle-aged and older adults: a secondary analysis |
| title_fullStr | Association of calf circumference with osteoporosis and hip fracture in middle-aged and older adults: a secondary analysis |
| title_full_unstemmed | Association of calf circumference with osteoporosis and hip fracture in middle-aged and older adults: a secondary analysis |
| title_short | Association of calf circumference with osteoporosis and hip fracture in middle-aged and older adults: a secondary analysis |
| title_sort | association of calf circumference with osteoporosis and hip fracture in middle aged and older adults a secondary analysis |
| topic | Osteoporosis Hip fracture Calf circumference Sarcopenia Osteosarcopenia Older adults |
| url | https://doi.org/10.1186/s12891-024-08237-9 |
| work_keys_str_mv | AT mumincao associationofcalfcircumferencewithosteoporosisandhipfractureinmiddleagedandolderadultsasecondaryanalysis AT yuanweizhang associationofcalfcircumferencewithosteoporosisandhipfractureinmiddleagedandolderadultsasecondaryanalysis AT mengzetong associationofcalfcircumferencewithosteoporosisandhipfractureinmiddleagedandolderadultsasecondaryanalysis AT xiangxuchen associationofcalfcircumferencewithosteoporosisandhipfractureinmiddleagedandolderadultsasecondaryanalysis AT ziangxu associationofcalfcircumferencewithosteoporosisandhipfractureinmiddleagedandolderadultsasecondaryanalysis AT renwangsheng associationofcalfcircumferencewithosteoporosisandhipfractureinmiddleagedandolderadultsasecondaryanalysis AT liushi associationofcalfcircumferencewithosteoporosisandhipfractureinmiddleagedandolderadultsasecondaryanalysis AT chengzhang associationofcalfcircumferencewithosteoporosisandhipfractureinmiddleagedandolderadultsasecondaryanalysis AT wenbinfan associationofcalfcircumferencewithosteoporosisandhipfractureinmiddleagedandolderadultsasecondaryanalysis AT tianxie associationofcalfcircumferencewithosteoporosisandhipfractureinmiddleagedandolderadultsasecondaryanalysis AT yingjuanli associationofcalfcircumferencewithosteoporosisandhipfractureinmiddleagedandolderadultsasecondaryanalysis AT jinyuwang associationofcalfcircumferencewithosteoporosisandhipfractureinmiddleagedandolderadultsasecondaryanalysis AT weigao associationofcalfcircumferencewithosteoporosisandhipfractureinmiddleagedandolderadultsasecondaryanalysis AT yunfengrui associationofcalfcircumferencewithosteoporosisandhipfractureinmiddleagedandolderadultsasecondaryanalysis |