Contribution of the infection ecosystem and biogeography to antibiotic failure in vivo
Abstract The acquisition of antibiotic resistance in bacteria, though a deeply concerning international issue, is reasonably well-understood at a mechanistic level. Less well-understood is why bacteria that are sensitive in vitro to well-established and widely-used antibiotics sometimes fail to resp...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | npj Antimicrobials and Resistance |
| Online Access: | https://doi.org/10.1038/s44259-024-00063-2 |
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| _version_ | 1846136779025940480 |
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| author | Rahan Rudland Nazeer Isabel Askenasy Jemima E. V. Swain Martin Welch |
| author_facet | Rahan Rudland Nazeer Isabel Askenasy Jemima E. V. Swain Martin Welch |
| author_sort | Rahan Rudland Nazeer |
| collection | DOAJ |
| description | Abstract The acquisition of antibiotic resistance in bacteria, though a deeply concerning international issue, is reasonably well-understood at a mechanistic level. Less well-understood is why bacteria that are sensitive in vitro to well-established and widely-used antibiotics sometimes fail to respond to these agents in vivo. This is a particularly common problem in chronic, polymicrobial infection scenarios. Here, we discuss this in vitro-in vivo disconnect from the perspective of the bacterium, focusing in particular on how infection micro/macro-environment, biogeography, and the presence of co-habiting species affect the response to antibiotics. Using selected exemplars, we also consider interventions that might improve treatment outcomes, as well as ecologically ‘eubiotic’ approaches that have less of an impact on the patient’s commensal microflora. In our view, the accrued data strongly suggest that we need a more comprehensive understanding of the in situ microbiology at infection sites. |
| format | Article |
| id | doaj-art-9033e7a03d764a86b3867b4a26d2853a |
| institution | Kabale University |
| issn | 2731-8745 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Antimicrobials and Resistance |
| spelling | doaj-art-9033e7a03d764a86b3867b4a26d2853a2024-12-08T12:47:05ZengNature Portfolionpj Antimicrobials and Resistance2731-87452024-12-01211710.1038/s44259-024-00063-2Contribution of the infection ecosystem and biogeography to antibiotic failure in vivoRahan Rudland Nazeer0Isabel Askenasy1Jemima E. V. Swain2Martin Welch3Department of Biochemistry, University of CambridgeDepartment of Biochemistry, University of CambridgeDepartment of Biochemistry, University of CambridgeDepartment of Biochemistry, University of CambridgeAbstract The acquisition of antibiotic resistance in bacteria, though a deeply concerning international issue, is reasonably well-understood at a mechanistic level. Less well-understood is why bacteria that are sensitive in vitro to well-established and widely-used antibiotics sometimes fail to respond to these agents in vivo. This is a particularly common problem in chronic, polymicrobial infection scenarios. Here, we discuss this in vitro-in vivo disconnect from the perspective of the bacterium, focusing in particular on how infection micro/macro-environment, biogeography, and the presence of co-habiting species affect the response to antibiotics. Using selected exemplars, we also consider interventions that might improve treatment outcomes, as well as ecologically ‘eubiotic’ approaches that have less of an impact on the patient’s commensal microflora. In our view, the accrued data strongly suggest that we need a more comprehensive understanding of the in situ microbiology at infection sites.https://doi.org/10.1038/s44259-024-00063-2 |
| spellingShingle | Rahan Rudland Nazeer Isabel Askenasy Jemima E. V. Swain Martin Welch Contribution of the infection ecosystem and biogeography to antibiotic failure in vivo npj Antimicrobials and Resistance |
| title | Contribution of the infection ecosystem and biogeography to antibiotic failure in vivo |
| title_full | Contribution of the infection ecosystem and biogeography to antibiotic failure in vivo |
| title_fullStr | Contribution of the infection ecosystem and biogeography to antibiotic failure in vivo |
| title_full_unstemmed | Contribution of the infection ecosystem and biogeography to antibiotic failure in vivo |
| title_short | Contribution of the infection ecosystem and biogeography to antibiotic failure in vivo |
| title_sort | contribution of the infection ecosystem and biogeography to antibiotic failure in vivo |
| url | https://doi.org/10.1038/s44259-024-00063-2 |
| work_keys_str_mv | AT rahanrudlandnazeer contributionoftheinfectionecosystemandbiogeographytoantibioticfailureinvivo AT isabelaskenasy contributionoftheinfectionecosystemandbiogeographytoantibioticfailureinvivo AT jemimaevswain contributionoftheinfectionecosystemandbiogeographytoantibioticfailureinvivo AT martinwelch contributionoftheinfectionecosystemandbiogeographytoantibioticfailureinvivo |