The causal effect of gut microbiome on pulmonary artery hypertension based on a two-sample Mendelian randomization study
Abstract Background Alterations in gut microbiota composition have been linked to the presence of pulmonary artery hypertension (PAH), but it is unclear whether gut microbiota directly causes PAH. Methods A two-sample Mendelian randomization approach was used to investigate the causal association be...
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BMC
2025-07-01
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| Series: | Nutrition & Metabolism |
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| Online Access: | https://doi.org/10.1186/s12986-025-00979-0 |
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| author | Detian Jiang Yuxin Chang Xiaowen Zhen Xin Zhao |
| author_facet | Detian Jiang Yuxin Chang Xiaowen Zhen Xin Zhao |
| author_sort | Detian Jiang |
| collection | DOAJ |
| description | Abstract Background Alterations in gut microbiota composition have been linked to the presence of pulmonary artery hypertension (PAH), but it is unclear whether gut microbiota directly causes PAH. Methods A two-sample Mendelian randomization approach was used to investigate the causal association between gut microbiota and PAH. Various MR methods were employed, including inverse variance weighted, MR-Egger, weighted median, weighted model, and simple mode, and instrumental variable heterogeneity was assessed using Cochran’s Q statistics. Results Seven bacterial genera were found to be associated with PAH in at least one MR method. Inverse variance weighted analysis showed that UBA7102 sp002315655 (odds ratio [OR] 0.36, 95% confidence interval [CI] 0.17–0.76, P = 0.007) had a protective effect against PAH. Other genera, including Anaeromassilibacillus sp001305115 (OR 1.61, 95% CI: 1.14–2.28, P = 0.006), CAG-776 sp000438195 (OR 1.40, 95% CI 1.10–1.7, P = 0.005), F0428 (OR 1.96, 95% CI 1.27–3.03, P = 0.002), GCA-900,066,495 (OR 1.66, 95% CI: 1.14–2.41, P = 0.007), Leptospirales (OR 5.81, 95% CI 1.53–22.0, P = 0.009) and Paenibacillus J (OR 3.20, 95% CI: 1.53–6.67, P = 0.001), presented a positive association with PAH. No significant instrumental variable heterogeneity was found, and but horizontal pleiotropy was not present in any bacterial taxa. Conclusions This two-sample Mendelian randomization study found that UBA7102 sp002315655, Anaeromassilibacillus sp001305115, CAG-776 sp000438195, F0428, GCA-900,066,495, Leptospirales, and Paenibacillus J may have a causal association with PAH. Further research is needed to determine the underlying mechanisms by which gut microbiota affects PAH. |
| format | Article |
| id | doaj-art-901bf1cea6f94013a5f80ba4be9dbc8d |
| institution | Kabale University |
| issn | 1743-7075 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition & Metabolism |
| spelling | doaj-art-901bf1cea6f94013a5f80ba4be9dbc8d2025-08-20T04:01:53ZengBMCNutrition & Metabolism1743-70752025-07-012211710.1186/s12986-025-00979-0The causal effect of gut microbiome on pulmonary artery hypertension based on a two-sample Mendelian randomization studyDetian Jiang0Yuxin Chang1Xiaowen Zhen2Xin Zhao3Department of Cardiovascular Surgery, Qilu Hospital of Shandong University (Qingdao)Department of Emergency, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital)Department of Emergency, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital)Department of Cardiovascular Surgery, Qilu Hospital of Shandong UniversityAbstract Background Alterations in gut microbiota composition have been linked to the presence of pulmonary artery hypertension (PAH), but it is unclear whether gut microbiota directly causes PAH. Methods A two-sample Mendelian randomization approach was used to investigate the causal association between gut microbiota and PAH. Various MR methods were employed, including inverse variance weighted, MR-Egger, weighted median, weighted model, and simple mode, and instrumental variable heterogeneity was assessed using Cochran’s Q statistics. Results Seven bacterial genera were found to be associated with PAH in at least one MR method. Inverse variance weighted analysis showed that UBA7102 sp002315655 (odds ratio [OR] 0.36, 95% confidence interval [CI] 0.17–0.76, P = 0.007) had a protective effect against PAH. Other genera, including Anaeromassilibacillus sp001305115 (OR 1.61, 95% CI: 1.14–2.28, P = 0.006), CAG-776 sp000438195 (OR 1.40, 95% CI 1.10–1.7, P = 0.005), F0428 (OR 1.96, 95% CI 1.27–3.03, P = 0.002), GCA-900,066,495 (OR 1.66, 95% CI: 1.14–2.41, P = 0.007), Leptospirales (OR 5.81, 95% CI 1.53–22.0, P = 0.009) and Paenibacillus J (OR 3.20, 95% CI: 1.53–6.67, P = 0.001), presented a positive association with PAH. No significant instrumental variable heterogeneity was found, and but horizontal pleiotropy was not present in any bacterial taxa. Conclusions This two-sample Mendelian randomization study found that UBA7102 sp002315655, Anaeromassilibacillus sp001305115, CAG-776 sp000438195, F0428, GCA-900,066,495, Leptospirales, and Paenibacillus J may have a causal association with PAH. Further research is needed to determine the underlying mechanisms by which gut microbiota affects PAH.https://doi.org/10.1186/s12986-025-00979-0Gut microbiotaPulmonary artery hypertensionMendelian randomization |
| spellingShingle | Detian Jiang Yuxin Chang Xiaowen Zhen Xin Zhao The causal effect of gut microbiome on pulmonary artery hypertension based on a two-sample Mendelian randomization study Nutrition & Metabolism Gut microbiota Pulmonary artery hypertension Mendelian randomization |
| title | The causal effect of gut microbiome on pulmonary artery hypertension based on a two-sample Mendelian randomization study |
| title_full | The causal effect of gut microbiome on pulmonary artery hypertension based on a two-sample Mendelian randomization study |
| title_fullStr | The causal effect of gut microbiome on pulmonary artery hypertension based on a two-sample Mendelian randomization study |
| title_full_unstemmed | The causal effect of gut microbiome on pulmonary artery hypertension based on a two-sample Mendelian randomization study |
| title_short | The causal effect of gut microbiome on pulmonary artery hypertension based on a two-sample Mendelian randomization study |
| title_sort | causal effect of gut microbiome on pulmonary artery hypertension based on a two sample mendelian randomization study |
| topic | Gut microbiota Pulmonary artery hypertension Mendelian randomization |
| url | https://doi.org/10.1186/s12986-025-00979-0 |
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