Human genetic variation determines 24-hour rhythmic gene expression and disease risk

Abstract 24-hour biological rhythms are essential to maintain physiological homeostasis. Disruption of these rhythms increases the risks of multiple diseases. Biological rhythms are known to have a genetic basis formed by core clock genes, but how individual genetic variation shapes the oscillating...

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Bibliographic Details
Main Authors: Ying Chen, Panpan Liu, Aniko Sabo, Dongyin Guan
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59524-5
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