5-ALA-Induced Fluorescent Urine Cytology in Comparison with Conventional Cytology, BTA-TRAK, and NMP-22 Tests in the Diagnosis of Bladder Cancer

Introduction To assess the sensitivity fluorescent urine cytology induced by 5-aminolevulinic acid (5-ALA) in the diagnosis of bladder cancer and to compare the sensitivity and specificity with currently available markers approved by the United States Food and Drug Administration (FDA), b...

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Main Authors: Rajendra B Nerli, Shadab Rangrez, Shridhar C. Ghagane, Parth Lalakia, Shoubhik Chandra, Shreya Chandra
Format: Article
Language:English
Published: Sociedade Brasileira de Oncologia Clínica, Sociedade Brasileira de Cirurgia Clínica and Sociedade Brasileira de Radioterapia 2025-01-01
Series:Brazilian Journal of Oncology
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Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1791752
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author Rajendra B Nerli
Shadab Rangrez
Shridhar C. Ghagane
Parth Lalakia
Shoubhik Chandra
Shreya Chandra
author_facet Rajendra B Nerli
Shadab Rangrez
Shridhar C. Ghagane
Parth Lalakia
Shoubhik Chandra
Shreya Chandra
author_sort Rajendra B Nerli
collection DOAJ
description Introduction To assess the sensitivity fluorescent urine cytology induced by 5-aminolevulinic acid (5-ALA) in the diagnosis of bladder cancer and to compare the sensitivity and specificity with currently available markers approved by the United States Food and Drug Administration (FDA), bladder tumour antigen (BTA-TRAK, Bard Diagnostic Sciences, Redmond, WA, United States) assay based on enzyme-linked immunosorbent assay (ELISA), nuclear matrix protein 22 (NMP-22), and conventional cytology.
format Article
id doaj-art-90060e66c3cc4a36959f9d68643d3a9e
institution Kabale University
issn 2526-8732
language English
publishDate 2025-01-01
publisher Sociedade Brasileira de Oncologia Clínica, Sociedade Brasileira de Cirurgia Clínica and Sociedade Brasileira de Radioterapia
record_format Article
series Brazilian Journal of Oncology
spelling doaj-art-90060e66c3cc4a36959f9d68643d3a9e2025-01-09T23:53:46ZengSociedade Brasileira de Oncologia Clínica, Sociedade Brasileira de Cirurgia Clínica and Sociedade Brasileira de RadioterapiaBrazilian Journal of Oncology2526-87322025-01-012110.1055/s-0044-17917525-ALA-Induced Fluorescent Urine Cytology in Comparison with Conventional Cytology, BTA-TRAK, and NMP-22 Tests in the Diagnosis of Bladder CancerRajendra B Nerli0https://orcid.org/0000-0002-6099-0208Shadab Rangrez1Shridhar C. Ghagane2https://orcid.org/0000-0001-8959-3209Parth Lalakia3Shoubhik Chandra4Shreya Chandra5Department of Urology and Urologic Oncology, Jawaharlal Nehru Medical College, KLE Academy of Higher Education and Research (Deemed-to-be-University), Belagavi, Karnataka, IndiaDepartment of Urology and Urologic Oncology, Jawaharlal Nehru Medical College, KLE Academy of Higher Education and Research (Deemed-to-be-University), Belagavi, Karnataka, IndiaDr. Prabhakar Kore Basic Science Research Centre, KLE Academy of Higher Education and Research (Deemed-to-be-University), Belagavi, Karnataka, IndiaCollege of Population Health, Office of Global Affairs, Thomas Jefferson University, Philadelphia, United StatesDepartment of Urology and Urologic Oncology, Jawaharlal Nehru Medical College, KLE Academy of Higher Education and Research (Deemed-to-be-University), Belagavi, Karnataka, IndiaDepartment of Pathology, Jawaharlal Nehru Medical College, KLE Academy of Higher Education and Research (Deemed-to-be-University), Belagavi, Karnataka, India Introduction To assess the sensitivity fluorescent urine cytology induced by 5-aminolevulinic acid (5-ALA) in the diagnosis of bladder cancer and to compare the sensitivity and specificity with currently available markers approved by the United States Food and Drug Administration (FDA), bladder tumour antigen (BTA-TRAK, Bard Diagnostic Sciences, Redmond, WA, United States) assay based on enzyme-linked immunosorbent assay (ELISA), nuclear matrix protein 22 (NMP-22), and conventional cytology.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1791752bladder cancercytologyurothelial carcinoma5-aminolevulinic acidsensitivityspecificity
spellingShingle Rajendra B Nerli
Shadab Rangrez
Shridhar C. Ghagane
Parth Lalakia
Shoubhik Chandra
Shreya Chandra
5-ALA-Induced Fluorescent Urine Cytology in Comparison with Conventional Cytology, BTA-TRAK, and NMP-22 Tests in the Diagnosis of Bladder Cancer
Brazilian Journal of Oncology
bladder cancer
cytology
urothelial carcinoma
5-aminolevulinic acid
sensitivity
specificity
title 5-ALA-Induced Fluorescent Urine Cytology in Comparison with Conventional Cytology, BTA-TRAK, and NMP-22 Tests in the Diagnosis of Bladder Cancer
title_full 5-ALA-Induced Fluorescent Urine Cytology in Comparison with Conventional Cytology, BTA-TRAK, and NMP-22 Tests in the Diagnosis of Bladder Cancer
title_fullStr 5-ALA-Induced Fluorescent Urine Cytology in Comparison with Conventional Cytology, BTA-TRAK, and NMP-22 Tests in the Diagnosis of Bladder Cancer
title_full_unstemmed 5-ALA-Induced Fluorescent Urine Cytology in Comparison with Conventional Cytology, BTA-TRAK, and NMP-22 Tests in the Diagnosis of Bladder Cancer
title_short 5-ALA-Induced Fluorescent Urine Cytology in Comparison with Conventional Cytology, BTA-TRAK, and NMP-22 Tests in the Diagnosis of Bladder Cancer
title_sort 5 ala induced fluorescent urine cytology in comparison with conventional cytology bta trak and nmp 22 tests in the diagnosis of bladder cancer
topic bladder cancer
cytology
urothelial carcinoma
5-aminolevulinic acid
sensitivity
specificity
url http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1791752
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