Efficacy and safety of recombinant human granulocyte colony-stimulating factor in patients with unexplained recurrent pregnancy loss: a protocol for a multicenter, randomized, double-blind, controlled trial

Abstract Background Unexplained recurrent pregnancy loss (uRPL), defined as the loss of two or more pregnancies without an identified cause, affects approximately 1–2% of women trying to conceive. Emerging evidence suggests that an imbalance in maternal–fetal immunological tolerance may play a key r...

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Bibliographic Details
Main Authors: Fangxiang Mu, Zhuhua Cai, Lirong Du, Xianghui Zeng, Qi Zhou, Yaolong Chen, Fang Wang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Trials
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Online Access:https://doi.org/10.1186/s13063-025-08951-2
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