Detection of circular permutations by Protein Language Models
Protein circular permutations are crucial for understanding protein evolution and functionality. Traditional detection methods face challenges: sequence-based approaches struggle with detecting distant homologs, while structure-based approaches are limited by the need for structure generation and of...
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Main Authors: | Yue Hu, Bin Huang, Chun Zi Zang, Jia Jie Xu |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2025-01-01
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Series: | Computational and Structural Biotechnology Journal |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037024004525 |
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