The impact of long-term isolation on anxiety, depressive-like and social behavior in aging Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) male rats

The impact of long-term isolation on anxiety, depressive-like and social behavior in aging Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) male rats

Abstract Aging is a complex process associated with multimorbidity. Hypertension, one of widespread states, is among main causes of age-related alterations in behavior, emotionality and sociability. We studied the effects of long-term isolated housing on anxiety, depressive-like and social behavior...

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Main Authors: Diana I. Mamedova, Olga A. Nedogreeva, Anna O. Manolova, Viktoria O. Ovchinnikova, Pavel A. Kostryukov, Natalia A. Lazareva, Yulia V. Moiseeva, Liya V. Tret’yakova, Alexey A. Kvichansky, Mikhail V. Onufriev, Victor A. Aniol, Margarita R. Novikova, Natalia V. Gulyaeva, Mikhail Yu. Stepanichev
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Aging
Social isolation
Hypertension
Spontaneously hypertensive rats
Wistar-Kyoto rats
Anxiety
Online Access:https://doi.org/10.1038/s41598-024-79677-5
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