Case report: Reversible splenial lesion syndrome preceding the onset of multiple sclerosis
BackgroundThe reversible splenial lesion syndrome is frequently associated with systemic and central nervous system infections. Whether an infection associated with the occurrence of the reversible splenial lesion syndrome could play a role in the later development of multiple sclerosis is unknown.M...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1517719/full |
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| author | Matthias Mauritz Dariia Kliushnikova Ferdinand Otto Andrea Harrer Andrea Harrer Tobias Moser Richard Friedrich Radlberger Waltraud Kleindienst Eugen Trinka Eugen Trinka Eugen Trinka Peter Wipfler |
| author_facet | Matthias Mauritz Dariia Kliushnikova Ferdinand Otto Andrea Harrer Andrea Harrer Tobias Moser Richard Friedrich Radlberger Waltraud Kleindienst Eugen Trinka Eugen Trinka Eugen Trinka Peter Wipfler |
| author_sort | Matthias Mauritz |
| collection | DOAJ |
| description | BackgroundThe reversible splenial lesion syndrome is frequently associated with systemic and central nervous system infections. Whether an infection associated with the occurrence of the reversible splenial lesion syndrome could play a role in the later development of multiple sclerosis is unknown.MethodsCase Report.ResultsA 27-year-old woman developed an infection-related reversible splenial lesion syndrome. Diagnostic findings did not establish a specific type of infection, but revealed evidence for a potential disposition towards autoimmunity. 32 months after the initial presentation, new clinical and radiological manifestations developed that led to a diagnosis of multiple sclerosis.ConclusionsIn susceptible individuals, infectious disease processes involving the central nervous system, such as described in this case, might be a factor in the pathogenesis of multiple sclerosis. More research on the prodromal stage of multiple sclerosis is needed to better understand the relationship between infections and autoimmunity. |
| format | Article |
| id | doaj-art-8fe7cf56a6324a79abfc776fbc2c0fcf |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-8fe7cf56a6324a79abfc776fbc2c0fcf2025-01-07T05:23:55ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15177191517719Case report: Reversible splenial lesion syndrome preceding the onset of multiple sclerosisMatthias Mauritz0Dariia Kliushnikova1Ferdinand Otto2Andrea Harrer3Andrea Harrer4Tobias Moser5Richard Friedrich Radlberger6Waltraud Kleindienst7Eugen Trinka8Eugen Trinka9Eugen Trinka10Peter Wipfler11Department of Neurology, Christian Doppler University Hospital, Paracelsus Medical University and Centre for Cognitive Neuroscience, Salzburg, AustriaDepartment of Neurology, Christian Doppler University Hospital, Paracelsus Medical University and Centre for Cognitive Neuroscience, Salzburg, AustriaDepartment of Neurology, Christian Doppler University Hospital, Paracelsus Medical University and Centre for Cognitive Neuroscience, Salzburg, AustriaDepartment of Neurology, Christian Doppler University Hospital, Paracelsus Medical University and Centre for Cognitive Neuroscience, Salzburg, AustriaDepartment of Dermatology and Allergology, Paracelsus Medical University, Salzburg, AustriaDepartment of Neurology, Christian Doppler University Hospital, Paracelsus Medical University and Centre for Cognitive Neuroscience, Salzburg, AustriaDepartment of Neurology, Christian Doppler University Hospital, Paracelsus Medical University and Centre for Cognitive Neuroscience, Salzburg, AustriaDepartment of Neurology, Christian Doppler University Hospital, Paracelsus Medical University and Centre for Cognitive Neuroscience, Salzburg, AustriaDepartment of Neurology, Christian Doppler University Hospital, Paracelsus Medical University and Centre for Cognitive Neuroscience, Salzburg, AustriaDepartment of Public Health, Health Services Research and Health Technology Assessment, UMIT – University for Health Sciences, Medical Informatics and Technology, Hall in Tirol, AustriaNeuroscience Institute, Christian Doppler University Hospital, Paracelsus Medical University, Salzburg, AustriaDepartment of Neurology, Christian Doppler University Hospital, Paracelsus Medical University and Centre for Cognitive Neuroscience, Salzburg, AustriaBackgroundThe reversible splenial lesion syndrome is frequently associated with systemic and central nervous system infections. Whether an infection associated with the occurrence of the reversible splenial lesion syndrome could play a role in the later development of multiple sclerosis is unknown.MethodsCase Report.ResultsA 27-year-old woman developed an infection-related reversible splenial lesion syndrome. Diagnostic findings did not establish a specific type of infection, but revealed evidence for a potential disposition towards autoimmunity. 32 months after the initial presentation, new clinical and radiological manifestations developed that led to a diagnosis of multiple sclerosis.ConclusionsIn susceptible individuals, infectious disease processes involving the central nervous system, such as described in this case, might be a factor in the pathogenesis of multiple sclerosis. More research on the prodromal stage of multiple sclerosis is needed to better understand the relationship between infections and autoimmunity.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1517719/fullreversible splenial lesion syndromeneuroimmunologymultiple sclerosisneuroinfectiologymultiple sclerosis pathogenesis |
| spellingShingle | Matthias Mauritz Dariia Kliushnikova Ferdinand Otto Andrea Harrer Andrea Harrer Tobias Moser Richard Friedrich Radlberger Waltraud Kleindienst Eugen Trinka Eugen Trinka Eugen Trinka Peter Wipfler Case report: Reversible splenial lesion syndrome preceding the onset of multiple sclerosis Frontiers in Immunology reversible splenial lesion syndrome neuroimmunology multiple sclerosis neuroinfectiology multiple sclerosis pathogenesis |
| title | Case report: Reversible splenial lesion syndrome preceding the onset of multiple sclerosis |
| title_full | Case report: Reversible splenial lesion syndrome preceding the onset of multiple sclerosis |
| title_fullStr | Case report: Reversible splenial lesion syndrome preceding the onset of multiple sclerosis |
| title_full_unstemmed | Case report: Reversible splenial lesion syndrome preceding the onset of multiple sclerosis |
| title_short | Case report: Reversible splenial lesion syndrome preceding the onset of multiple sclerosis |
| title_sort | case report reversible splenial lesion syndrome preceding the onset of multiple sclerosis |
| topic | reversible splenial lesion syndrome neuroimmunology multiple sclerosis neuroinfectiology multiple sclerosis pathogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1517719/full |
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