Lactate and Lactylation: Dual Regulators of T-Cell-Mediated Tumor Immunity and Immunotherapy

Lactate and Lactylation: Dual Regulators of T-Cell-Mediated Tumor Immunity and Immunotherapy

Lactate and its derivative, lactylation, play pivotal roles in modulating immune responses within the tumor microenvironment (TME), particularly in T-cell-mediated cancer immunotherapy. Elevated lactate levels, a hallmark of the Warburg effect, contribute to immune suppression through CD8<sup>...

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Bibliographic Details
Main Authors: Zhi-Nan Hao, Xiao-Ping Tan, Qing Zhang, Jie Li, Ruohan Xia, Zhaowu Ma
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Biomolecules
Subjects:
lactate
lactylation
T cell
immune modulation
glycolysis
tumor microenvironment
Online Access:https://www.mdpi.com/2218-273X/14/12/1646
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