LC-MS/MS assisted pharmacokinetic and tissue distribution study of ropivacaine and 3-OH-ropivacaine on rats after plane block anesthesia

LC-MS/MS assisted pharmacokinetic and tissue distribution study of ropivacaine and 3-OH-ropivacaine on rats after plane block anesthesia

Knowledge of drug pharmacokinetics and tissue distribution is precious for ensuring patient safety and optimizing treatments. The varied use of local anesthetics, as well as the fact that anesthetics can sometimes have low therapeutic indices and numerous adverse drug reactions, makes any novel phar...

Full description

Saved in:

Bibliographic Details
Main Authors:	Mihaela Butiulca, Lenard Farczadi, Silvia Imre, Camil Eugen Vari, Laurian Vlase, Bogdan Cordos, Leonard Azamfirei, Alexandra Elena Lazar
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Pharmacology
Subjects:	ropivacaine pharmacokinetics LC-MS/MS rats HPLC
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1494646/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Comparison of ropivacaine with ropivacaine–dexamethasone combination for postoperative analgesia in the pectoral nerve block for modified radical mastectomy: A randomized clinical trial
by: Veena Mathur, et al.
Published: (2024-12-01)

Discovery of novel serum peptide biomarkers for cholangiocarcinoma recurrence through MALDI-TOF MS and LC–MS/MS peptidome analysis
by: Vasin Thanasukarn, et al.
Published: (2025-01-01)

Identification and pharmacokinetics of saponins in Rhizoma Anemarrhenae after oral administration to rats by HPLC-Q-TOF/MS and HPLC-MS/MS
by: Wang Hai-Qiao, et al.
Published: (2021-12-01)

Local anesthetic systemic toxicity after brachial plexus block with ropivacaine: a case report
by: A.G. Tutunnyk, et al.
Published: (2024-12-01)

Characterization of Anthocyanins Including Acetylated Glycosides from Highbush Blueberry (<i>Vaccinium corymbosum</i> L.) Cultivated in Korea Based on UPLC-DAD-QToF/MS and UPLC-Qtrap-MS/MS
by: Ju Hyung Kim, et al.
Published: (2025-01-01)

Simultaneous Determination of Multiple Acid-Suppressing Drugs by UPLC-MS/MS Method and Application for Pharmacokinetics Study
by: Li X, et al.
Published: (2025-02-01)

Effect of Ropivacaine Combined with Nalbuphine in Erector Spinae Plane Block on Postoperative Analgesia in Lumbar Trauma Surgery: A Single-Center Randomized Controlled Trial
by: Zhang J, et al.
Published: (2025-01-01)

Adulteration detection of plant protein beverages by UPLC-MS/MS based on signature peptide of allergen
by: Yawei Ning, et al.
Published: (2024-11-01)

UHPLC-MS/MS based comprehensive phenolic profiling, antimicrobial and antioxidant activities of Indian Rhodomyrtus tomentosa fruits
by: A Divya Priya, et al.
Published: (2025-01-01)

A comprehensive investigation of Clerodendrum Infortunatum Linn. using LC-QTOF-MS/MS metabolomics as a promising anti-alzheimer candidate
by: Fatma Atef, et al.
Published: (2025-01-01)

Identification of serum biomarkers for cystic echinococcosis in sheep through untargeted metabolomic analysis using LC–MS/MS technology
by: Xiao-Xia Wu, et al.
Published: (2024-12-01)

Determination of Puberulic Acid in Monascus-Fermented Red Yeast Rice by LC-MS/MS Combined with Precolumn Derivatization
by: Hui-Qin Pan, et al.
Published: (2024-12-01)

New LC-MS/MS method for the determination of unconventional organic pollutants: perfluoroalkyl sulfonic acids in wastewater, surface water, and drinking water
by: Florentina Laura Chiriac, et al.
Published: (2024-12-01)

Establishment and evaluation of a UPLC-MS/MS method for simultaneous determination of bongkrekic acid and dehydroacetic acid in rice noodles
by: Lingguo Zhao, et al.
Published: (2025-01-01)

UPLC-MS/MS Method for Givinostat in Rat Plasma: Development, Validation, in vivo Pharmacokinetics Study and in vitro Metabolic Stability Research
by: Zhan R, et al.
Published: (2025-01-01)

Levobupivacaine versus ropivacaine for brachial plexus block: A systematic review and meta-analysis of randomised controlled trials
by: Abdullah M. Alharran, et al.

Minimum effective concentration 90 (EC90) of ropivacaine for Femoral nerve block: A biased-coin up-and-down sequential method study
by: Ahmed M. Taha, et al.

Quantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay
by: Linlin Dong, et al.
Published: (2024-12-01)

The Nexus between Renewable Energy, Economic Growth, and Carbon Dioxide Emissions: Evidence from MS-VAR and MS-Granger Causality Methods
by: Ayça Büyükyılmaz Ercan, et al.
Published: (2024-12-01)

Simultaneous Determination of Three Active Forms of Vitamin B12 In Situ Produced During Fermentation by LC-MS/MS
by: Zhihao Fan, et al.
Published: (2025-01-01)

Development and validation of an LC-MS/MS method for the simultaneous estimation of tadalafil and macitentan in rat plasma: Greenness assessment and design of experiment approach
by: Sravanthi Gandu, et al.
Published: (2025-03-01)

Stability study of thymoquinone, carvacrol and thymol using HPLC-UV and LC-ESI-MS
by: Soliman Rabab M., et al.
Published: (2020-09-01)

Valorization of local regional apple (Malus domestica Borkh.) cultivars versus commercial samples from Spain: Phenolic compounds by HPLC-MS/MS, cytotoxicity and biological potential on nitric oxide radicals and lipoxygenase inhibition
by: Adrián Millán-Laleona, et al.
Published: (2025-01-01)

Quantitative analysis and pharmacokinetic study of a novel diarylurea EGFR inhibitor (ZCJ14) in rat plasma using a validated LC-MS/MS method
by: Zuo Sai-Jie, et al.
Published: (2021-09-01)

Identification of compounds against atherosclerosis induced by ox-LDL based on cell extraction/UPLC–MS/MS from mulberry twigs and their mechanistic analysis
by: Zhihui Jin, et al.
Published: (2025-01-01)

Exploration of Degradation Mechanism of Chlorogenic Acids in Stevia Based on UPLC-QTOF MS/MS
by: Juan-juan WU, et al.
Published: (2025-01-01)

An Injectable Oil-Based Depot Formulation of <i>N</i>-Acyloxymethyl Prodrug of Ropivacaine for Long-Acting Local Analgesia: Formulation Development and In Vitro/In Vivo Evaluation
by: Xiaowei Liu, et al.
Published: (2024-12-01)

Metabolite profile of Passiflora mollisima leaf using UHPLC-ESI-MS and its potential anxiolytic activity in mice
by: Carmen Luisa Marìn-Tello, et al.
Published: (2024-12-01)

Development and Validation of a Robust and Straightforward LC-MS Method for Measuring Taurine in Whole Blood and Plasma of Dogs and Reference Intervals Calculation
by: Tommaso Furlanello, et al.
Published: (2024-12-01)

Ultrasound-guided thoracic paravertebral injection of dexamethasone palmitate combined with ropivacaine for the treatment of thoracic herpes zoster-related pain: protocol for a prospective, randomized controlled, single-center study
by: Liu Wang, et al.
Published: (2025-01-01)

GC-MS analysis of cholesterol lowering dietary supplements
by: Velislava Todorova, et al.
Published: (2024-12-01)

Simultaneous determination of nirmatrelvir, ritonavir, and beta-D-N4-hydroxycytidine in human plasma and epithelial lining fluid using LC-MS/MS and its clinical application to compare rates of achieving effective concentrations
by: Wenjing Zhang, et al.
Published: (2025-01-01)

Investigation of metabolic features of glioblastoma tissue and the peritumoral environment using targeted metabolomics screening by LC-MS/MS and gene network analysis
by: N. V. Basov, et al.
Published: (2025-01-01)

A randomized sequential allocation study on the optimum programmed intermittent epidural boluses interval time with different concentrations of ropivacaine combined with the dural puncture epidural technique for labor analgesia
by: Jingjing Mao, et al.
Published: (2025-01-01)

Based on theoretical design simultaneous analysis of multiple neonicotinoid pesticides in beeswax by deep eutectic solvents extraction combined with UHPLC-MS/MS
by: Guodong Mu, et al.
Published: (2025-01-01)

Tracing the change of the volatile compounds of soy sauce at different fermentation times by PTR-TOF-MS, E-nose and GC–MS
by: Qixin Kan, et al.
Published: (2025-01-01)

El enigma de la parte central del Ms. Aubin No 20 y la relación con sus copias
by: Katarzyna Mikulska
Published: (2018-06-01)

A straightforward Py-GC/MS methodology for quantification of microplastics in tap water
by: Alexander Ccanccapa-Cartagena, et al.
Published: (2025-06-01)

LC-MS based analysis reveal antimicrobial compounds from Gabonese pharmacopoeia: chemical characterisation and cytotoxicity evaluation
by: Elvis Otogo N’nang, et al.
Published: (2025-01-01)

Chemical Composition Analysis of the Patented Naoxueshuan Formula Based on UPLC-Q-TOF MS and GC-MS
by: Chang LIU, et al.
Published: (2025-01-01)