Senolytic cocktail dasatinib and quercetin attenuates chronic high altitude hypoxia associated bone loss in mice

Senolytic cocktail dasatinib and quercetin attenuates chronic high altitude hypoxia associated bone loss in mice

Abstract Chronic high-altitude hypoxia (CHH) induces irreversible abnormalities in various organisms. Emerging evidence indicates that CHH markedly suppresses bone mass and bone strength. Targeting senescent cells and the consequent senescence-associated secretory phenotype (SASP) with senolytics is...

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Main Authors: Shen Wang, Juan Zhai, Ke Heng, Liangwei Sha, Xingchen Song, Huaiyuan Zhai, Chengbai Dai, Jian Li, Fei Teng, Junli Huang, Guoqiang Wang, Yinuo Geng, Rui Geng, Qingguo Lu, Xinfa Nie, Kui Xue, Qilong Wang, Wanying Huang, Huanyu Zhang, Yuanji Yang, Junyun Lan, Dehong Yu, Yanhong Liu, Yilong Guo, Qinghe Geng
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Osteoporosis
Chronic hypobaric hypoxia (CHH)
Dasatinib and quercetin (DQ)
Bone marrow stem cells (BMSCs)
Angiogenesis
Cellular senescence
Online Access:https://doi.org/10.1038/s41598-024-82262-5
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