PTHrP-induced hypercalcemic psychosyndrome under combined anti-PD-L1 and anti-EGFR inhibition in penile squamous cell carcinoma – A case report

PTHrP-induced hypercalcemic psychosyndrome under combined anti-PD-L1 and anti-EGFR inhibition in penile squamous cell carcinoma – A case report

Introduction: Paraneoplastic hypercalcemia is a life-threatening complication and is usually caused by tumoral secretion of parathyroid hormone-related peptide (PTHrP). Endocrinopathies are common adverse events of immune checkpoint inhibitor (ICI) therapy, but only few reports describe ICI-induced...

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Main Authors: Lea Jessica Albrecht, Viktor Grünwald, Jürgen C. Becker, Ralf Gutzmer, Livia Asan, Ellen Uslar, Alexandra Eilers, Anne-Christine Müseler, Alexander Roesch, Dirk Schadendorf, Lisa Zimmer, Elisabeth Livingstone
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:EJC Skin Cancer
Subjects:
Immune checkpoint inhibition
Hypercalcemia of malignancy
Penile squamous cell carcinoma
Hypercalcemic psychosyndrome
Immune-mediated hypercalcemia
Online Access:http://www.sciencedirect.com/science/article/pii/S2772611824002490
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