ANTIBACTERIAL ACTIVITY OF PURIFIED EXTRACT OF AFRICAN LEAVES (Vernonia amygdalina Delile) AGAINST Escherichia coli

The African leaf (Vernonia amygdalina Delile) is an Indonesian plant used by the community as a traditional medicine. V.amygdalina contains active compounds such as flavonoids, tannins, saponins, and steroids which have antibacterial properties. This study aims to determine the antibacterial activi...

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Main Authors: Nina Karlina, Tri Putri Septiyati, Didin Ahidin, Muhammad Yani Zam Zam, Indah Setyaningsih, Sulistiorini Indriaty, Aan Kunaedi, Yadi Supriyadi
Format: Article
Language:Indonesian
Published: Universitas Muhammadiyah Magelang 2024-12-01
Series:Jurnal Farmasi Sains dan Praktis
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Online Access:https://journal.unimma.ac.id/index.php/pharmacy/article/view/10781
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author Nina Karlina
Tri Putri Septiyati
Didin Ahidin
Muhammad Yani Zam Zam
Indah Setyaningsih
Sulistiorini Indriaty
Aan Kunaedi
Yadi Supriyadi
author_facet Nina Karlina
Tri Putri Septiyati
Didin Ahidin
Muhammad Yani Zam Zam
Indah Setyaningsih
Sulistiorini Indriaty
Aan Kunaedi
Yadi Supriyadi
author_sort Nina Karlina
collection DOAJ
description The African leaf (Vernonia amygdalina Delile) is an Indonesian plant used by the community as a traditional medicine. V.amygdalina contains active compounds such as flavonoids, tannins, saponins, and steroids which have antibacterial properties. This study aims to determine the antibacterial activity and the most effective concentration of purified extracts of V.amygdalina against the Escherichia coli bacteria. V.amygdalina simplicia was extracted using the maceration method. Ethanolic extract V.amygdalina was tested for the quality of the extract parameters and purified. Then, the purified extract V.amygdalina was tested for phytochemical screening and antibacterial activity against Escherichia coli bacteria by well-diffusion with concentrations of 30%, 40%, and 50%. The result of the quality parameter test for ethanolic extract V.amygdalina meets the requirements of specific and non-specific parameters. Purified extract V.amygdalina positively contains flavonoids, tannins, saponins, and steroids. Antibacterial activity of 0.05% chloramphenicol and purified extract V.amygdalina concentrations of 30%, 40%, and 50% against Escherichia coli bacteria had inhibition of 23.42 mm, 8.40± 0.315 mm, 9.44± 0.543 mm, and 11.59 ± 1,640 mm. The produced most effective inhibition was at a concentration of 50%. The results showed that the purified extract of V.amygdalina has antibacterial activity in the moderate to strong category, and the most effective concentration against Escherichia coli bacteria is the concentration of 50%.
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institution Kabale University
issn 2549-9068
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language Indonesian
publishDate 2024-12-01
publisher Universitas Muhammadiyah Magelang
record_format Article
series Jurnal Farmasi Sains dan Praktis
spelling doaj-art-8f70c99bd3384d0cb86b1a3b55d2a8372024-12-23T06:02:52ZindUniversitas Muhammadiyah MagelangJurnal Farmasi Sains dan Praktis2549-90682579-45582024-12-0110310.31603/pharmacy.v10i3.10781ANTIBACTERIAL ACTIVITY OF PURIFIED EXTRACT OF AFRICAN LEAVES (Vernonia amygdalina Delile) AGAINST Escherichia coliNina Karlina0Tri Putri Septiyati1Didin Ahidin2Muhammad Yani Zam Zam3Indah Setyaningsih4Sulistiorini Indriaty5Aan Kunaedi6Yadi Supriyadi7Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Muhammadiyah Ahmad Dahlan Cirebon, West Java 45153, IndonesiaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Muhammadiyah Ahmad Dahlan Cirebon, West Java 45153, IndonesiaDepartment of Pharmacology, Faculty of Pharmacy, Universitas Muhammadiyah Ahmad Dahlan Cirebon, West Java 45153, IndonesiaDepartment of Pharmaceutical Analysis and Medical Chemistry, Faculty of Pharmacy, Universitas Muhammadiyah Ahmad Dahlan Cirebon, West Java 45153, IndonesiaDepartment of Pharmacology, Faculty of Pharmacy, Universitas Muhammadiyah Ahmad Dahlan Cirebon, West Java 45153, IndonesiaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Muhammadiyah Ahmad Dahlan Cirebon, West Java 45153, IndonesiaDepartment of Pharmacology, Faculty of Pharmacy, Universitas Muhammadiyah Ahmad Dahlan Cirebon, West Java 45153, IndonesiaDepartment of Pharmacology, Faculty of Pharmacy, Universitas Muhammadiyah Ahmad Dahlan Cirebon, West Java 45153, Indonesia The African leaf (Vernonia amygdalina Delile) is an Indonesian plant used by the community as a traditional medicine. V.amygdalina contains active compounds such as flavonoids, tannins, saponins, and steroids which have antibacterial properties. This study aims to determine the antibacterial activity and the most effective concentration of purified extracts of V.amygdalina against the Escherichia coli bacteria. V.amygdalina simplicia was extracted using the maceration method. Ethanolic extract V.amygdalina was tested for the quality of the extract parameters and purified. Then, the purified extract V.amygdalina was tested for phytochemical screening and antibacterial activity against Escherichia coli bacteria by well-diffusion with concentrations of 30%, 40%, and 50%. The result of the quality parameter test for ethanolic extract V.amygdalina meets the requirements of specific and non-specific parameters. Purified extract V.amygdalina positively contains flavonoids, tannins, saponins, and steroids. Antibacterial activity of 0.05% chloramphenicol and purified extract V.amygdalina concentrations of 30%, 40%, and 50% against Escherichia coli bacteria had inhibition of 23.42 mm, 8.40± 0.315 mm, 9.44± 0.543 mm, and 11.59 ± 1,640 mm. The produced most effective inhibition was at a concentration of 50%. The results showed that the purified extract of V.amygdalina has antibacterial activity in the moderate to strong category, and the most effective concentration against Escherichia coli bacteria is the concentration of 50%. https://journal.unimma.ac.id/index.php/pharmacy/article/view/10781African leavesPurified extractAntibacterial activity
spellingShingle Nina Karlina
Tri Putri Septiyati
Didin Ahidin
Muhammad Yani Zam Zam
Indah Setyaningsih
Sulistiorini Indriaty
Aan Kunaedi
Yadi Supriyadi
ANTIBACTERIAL ACTIVITY OF PURIFIED EXTRACT OF AFRICAN LEAVES (Vernonia amygdalina Delile) AGAINST Escherichia coli
Jurnal Farmasi Sains dan Praktis
African leaves
Purified extract
Antibacterial activity
title ANTIBACTERIAL ACTIVITY OF PURIFIED EXTRACT OF AFRICAN LEAVES (Vernonia amygdalina Delile) AGAINST Escherichia coli
title_full ANTIBACTERIAL ACTIVITY OF PURIFIED EXTRACT OF AFRICAN LEAVES (Vernonia amygdalina Delile) AGAINST Escherichia coli
title_fullStr ANTIBACTERIAL ACTIVITY OF PURIFIED EXTRACT OF AFRICAN LEAVES (Vernonia amygdalina Delile) AGAINST Escherichia coli
title_full_unstemmed ANTIBACTERIAL ACTIVITY OF PURIFIED EXTRACT OF AFRICAN LEAVES (Vernonia amygdalina Delile) AGAINST Escherichia coli
title_short ANTIBACTERIAL ACTIVITY OF PURIFIED EXTRACT OF AFRICAN LEAVES (Vernonia amygdalina Delile) AGAINST Escherichia coli
title_sort antibacterial activity of purified extract of african leaves vernonia amygdalina delile against escherichia coli
topic African leaves
Purified extract
Antibacterial activity
url https://journal.unimma.ac.id/index.php/pharmacy/article/view/10781
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AT didinahidin antibacterialactivityofpurifiedextractofafricanleavesvernoniaamygdalinadelileagainstescherichiacoli
AT muhammadyanizamzam antibacterialactivityofpurifiedextractofafricanleavesvernoniaamygdalinadelileagainstescherichiacoli
AT indahsetyaningsih antibacterialactivityofpurifiedextractofafricanleavesvernoniaamygdalinadelileagainstescherichiacoli
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