The Multi-Loci Genotypes of the Myostatin Gene Associated with Growth Indicators of Intensively Fattened Lambs of Latvian Sheep
Myostatin (MSTN), a member of the TGFβ superfamily, negatively affects skeletal muscle growth and controls muscle development at stages of pre-natal muscle growth. Marker-assisted selection with molecular markers of the MSTN gene can be used in animal husbandry for higher-quality and more economical...
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MDPI AG
2024-11-01
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| author | Ilva Trapina Daina Kairisa Samanta Plavina Nikole Krasnevska Jegors Paramonovs Liga Senfelde Natalia Paramonova |
| author_facet | Ilva Trapina Daina Kairisa Samanta Plavina Nikole Krasnevska Jegors Paramonovs Liga Senfelde Natalia Paramonova |
| author_sort | Ilva Trapina |
| collection | DOAJ |
| description | Myostatin (MSTN), a member of the TGFβ superfamily, negatively affects skeletal muscle growth and controls muscle development at stages of pre-natal muscle growth. Marker-assisted selection with molecular markers of the MSTN gene can be used in animal husbandry for higher-quality and more economically profitable lambs. The study aims to identify multi-locus genotypes within the MSTN gene regions as molecular markers for fattening, feed efficiency, and carcass traits in Latvian sheep. This analysis was conducted on 76 intensively fattened male lambs representing six breeds in Latvia. Nine genotypes were identified based on four SNPs in the promoter and exon 1 regions, while six and four SNPs in introns 1 and 2 led to the formation of 14 and 10 genotypes, respectively. Six genotypes identified in the 3′UTR were significantly linked to traits such as birth weight, slaughter yield, muscle development, fat depth, average daily gain, dry matter intake, and feed efficiency. Genotypes of intron 1 were associated with slaughter yield, while genotypes of intron 2 were linked to fat depth, dry matter intake, and residual weight gain. The study concludes that MSTN gene SNPs can be used in selection to enhance sheep breeds in Latvia and improve economic outcomes for breeders. |
| format | Article |
| id | doaj-art-8f5b6db772a54656b68ae47d200416d9 |
| institution | Kabale University |
| issn | 2076-2615 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Animals |
| spelling | doaj-art-8f5b6db772a54656b68ae47d200416d92024-11-08T14:32:43ZengMDPI AGAnimals2076-26152024-11-011421314310.3390/ani14213143The Multi-Loci Genotypes of the Myostatin Gene Associated with Growth Indicators of Intensively Fattened Lambs of Latvian SheepIlva Trapina0Daina Kairisa1Samanta Plavina2Nikole Krasnevska3Jegors Paramonovs4Liga Senfelde5Natalia Paramonova6Genomics and Bioinformatics, Institute of Biology, Faculty of Medicine and Life Sciences, The University of Latvia, Jelgava Str. 3, LV-1004 Riga, LatviaInstitute of Agrobiotechnology, Faculty of Agriculture, Latvian University of Life Sciences and Technologies, Liela Street 2, LV-3001 Jelgava, LatviaGenomics and Bioinformatics, Institute of Biology, Faculty of Medicine and Life Sciences, The University of Latvia, Jelgava Str. 3, LV-1004 Riga, LatviaGenomics and Bioinformatics, Institute of Biology, Faculty of Medicine and Life Sciences, The University of Latvia, Jelgava Str. 3, LV-1004 Riga, LatviaGenomics and Bioinformatics, Institute of Biology, Faculty of Medicine and Life Sciences, The University of Latvia, Jelgava Str. 3, LV-1004 Riga, LatviaInstitute of Agrobiotechnology, Faculty of Agriculture, Latvian University of Life Sciences and Technologies, Liela Street 2, LV-3001 Jelgava, LatviaGenomics and Bioinformatics, Institute of Biology, Faculty of Medicine and Life Sciences, The University of Latvia, Jelgava Str. 3, LV-1004 Riga, LatviaMyostatin (MSTN), a member of the TGFβ superfamily, negatively affects skeletal muscle growth and controls muscle development at stages of pre-natal muscle growth. Marker-assisted selection with molecular markers of the MSTN gene can be used in animal husbandry for higher-quality and more economically profitable lambs. The study aims to identify multi-locus genotypes within the MSTN gene regions as molecular markers for fattening, feed efficiency, and carcass traits in Latvian sheep. This analysis was conducted on 76 intensively fattened male lambs representing six breeds in Latvia. Nine genotypes were identified based on four SNPs in the promoter and exon 1 regions, while six and four SNPs in introns 1 and 2 led to the formation of 14 and 10 genotypes, respectively. Six genotypes identified in the 3′UTR were significantly linked to traits such as birth weight, slaughter yield, muscle development, fat depth, average daily gain, dry matter intake, and feed efficiency. Genotypes of intron 1 were associated with slaughter yield, while genotypes of intron 2 were linked to fat depth, dry matter intake, and residual weight gain. The study concludes that MSTN gene SNPs can be used in selection to enhance sheep breeds in Latvia and improve economic outcomes for breeders.https://www.mdpi.com/2076-2615/14/21/3143intensive fatteningfeed efficiencymyostatinLatvian sheepmulti-loci genotypegenetic markers |
| spellingShingle | Ilva Trapina Daina Kairisa Samanta Plavina Nikole Krasnevska Jegors Paramonovs Liga Senfelde Natalia Paramonova The Multi-Loci Genotypes of the Myostatin Gene Associated with Growth Indicators of Intensively Fattened Lambs of Latvian Sheep Animals intensive fattening feed efficiency myostatin Latvian sheep multi-loci genotype genetic markers |
| title | The Multi-Loci Genotypes of the Myostatin Gene Associated with Growth Indicators of Intensively Fattened Lambs of Latvian Sheep |
| title_full | The Multi-Loci Genotypes of the Myostatin Gene Associated with Growth Indicators of Intensively Fattened Lambs of Latvian Sheep |
| title_fullStr | The Multi-Loci Genotypes of the Myostatin Gene Associated with Growth Indicators of Intensively Fattened Lambs of Latvian Sheep |
| title_full_unstemmed | The Multi-Loci Genotypes of the Myostatin Gene Associated with Growth Indicators of Intensively Fattened Lambs of Latvian Sheep |
| title_short | The Multi-Loci Genotypes of the Myostatin Gene Associated with Growth Indicators of Intensively Fattened Lambs of Latvian Sheep |
| title_sort | multi loci genotypes of the myostatin gene associated with growth indicators of intensively fattened lambs of latvian sheep |
| topic | intensive fattening feed efficiency myostatin Latvian sheep multi-loci genotype genetic markers |
| url | https://www.mdpi.com/2076-2615/14/21/3143 |
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